İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Aesthetic efficacy of resin infiltration on post-orthodontic white spot lesions using different conditioning methods: 24-month randomized control follow-up
(Allen Press Inc., 2026) Karaman, Emel; Ünsal, Kübra Alan; Öz, Aslıhan Zeynep; Öz, Abdullah Alper; Ercin, Özlem
Objectives: To assess color and fluorescence changes in post-orthodontic white spot lesions (WSLs) using different surface conditioning methods from prior to resin infiltration to a 24-month follow-up. Materials and Methods: Thirty patients, each with a minimum of four WSLs with ICDAS (International Caries Detection and Assessment System) II code 1 and 2 after bracket debonding were included. After baseline (T0), the lesions were randomly divided into four groups: regular brushing, 15% HCl (hydrogen chloride) gel, 37% H3PO4(phosphoric acid) gel, and Er:YAG (erbium-doped yttrium aluminium garnet) laser. Icon resin infiltration was applied. In the treatment groups, color and fluorescence were reexamined just after the resin infiltration treatment (T1), and after 6 (T2) and 24 months (T3). Results: There were no significant fluorescence or color changes between the treatment groups for the different time intervals. The control group showed a significantly lower color change from T0 to T2 and T0 to T3 than all the treatment groups whereas, at T2–T3, the control group showed the greatest improvement. Conclusions: Resin infiltration caused greater esthetic improvement and more revival of the lost fluorescence than daily brushing. HCl gel, H3PO4gel, and Er:YAG laser are adequate conditioning methods for resin infiltration of post-orthodontic WSLs with ICDAS II code 1 and 2. (Angle Orthod. 2026;96:311–317.). © 2026, Allen Press Inc. All rights reserved.
Validity and Reliability of the Turkish Version of the Diabetes Education Questionnaire in People with Diabetes
(AVES, 2026) Şafak, Yiğit; Akıncı, Buket; Ekşi, Büşra Ülker; İdiz, Cemile; Şahin, Hümeyra Rekalı; Çevikdizci, Melike; Ghisi, Gabriela Lima de Melo; Satman, İlhan
Objective: Patient education is a key component of diabetes management and chronic disease care, facilitating behavioral changes and supporting effective self-management. Reliable instruments for assessing patients’ diabetes knowledge are essential for identifying educational needs and designing evidence-based strategies. The purpose of this study was to examine the reliability and validity of the Turkish adaptation of the Diabetes Education Questionnaire (DATE-Q) in evaluating the diabetes knowledge of individuals with diabetes. Methods: This methodological study was conducted with 200 people with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The study involved translation, back-translation, and cross-cultural adaptation of the DATE-Q. The Turkish version of the Revised Diabetes Knowledge Test (DKT2) was used for validation. Criterion validity was assessed using Spearman's correlation between DATE-Q and DKT2. Cronbach’s alpha and intraclass correlation coefficient (ICC) values were used to determine the reliability. Results: Participants had a mean age of 55.9 ± 12.5 years, 63% were female, and 82.5% had T2DM. The Turkish DATE-Q demonstrated moderate criterion validity with the DKT2 (r = 0.576, P < .001). Internal consistency was excellent (Cronbach’s alpha = 0.90), and test–retest reliability was strong (ICC = 0.80-0.96). Conclusion: The Turkish version of the DATE-Q is a moderately valid and strongly reliable tool for assessing diabetes knowledge. Its use in research and clinical settings can support endocrinologists, physiotherapists, dietitians, and nurses in identifying patients’ knowledge gaps, developing tailored education programs, and promoting effective self-management strategies. Incorporating the DATE-Q into multidisciplinary diabetes care may enhance patient outcomes and help prevent diabetes-related complications. © 2026, AVES. All rights reserved.
Disaster management in Türkiye: a qualitative study on healthcare professionals
(2026) Mutlu, Hatice; Türkoğlu, Mesut Can; Erküvün, Kübra Sezen
Background Disasters pose complex challenges that extend beyond immediate emergency response, requiring well-coordinated, resilient, and health-centered disaster management systems. In disaster-prone countries such as Türkiye, understanding how health services, particularly specialized medical rescue teams, function in real disaster settings is critical for identifying systemic gaps and improving preparedness, coordination, and response capacity. The aim of this study is to examine the managerial and organizational challenges encountered in disaster management processes based on the experiences of UMKE personnel who have served during various disasters in Türkiye, and to derive implications for strengthening disaster preparedness and response capacity. Methods The study was conducted using a qualitative research design. In-depth interviews were carried out with healthcare professionals who participated in disaster response. The data were analyzed using thematic analysis, and the findings were categorized into five main themes: shortages of logistics and equipment; working conditions and training; social awareness; lack of coordination, communication, and organization; and institutional structure and local empowerment. Results The findings revealed that road damages hindered transportation and that alternative transportation plans were inadequate. Disaster training were not fully adapted to field conditions. Public disaster literacy was found to be low. Insufficient coordination and communication disrupted interventions. In addition, the study identified psychosocial support, community-based education, and institutional capacity building as critical components of effective disaster management. Conclusions This study was designed to capture the personal perspectives of healthcare professionals who directly confronted disasters and gained first-hand experience of related processes. Therefore, it provides a unique contribution by presenting a disaster management framework through the lens of healthcare professionals and by highlighting areas in need of improvement for policymakers in this field.
Comparison of color stability and wear resistance of different 3D printed definitive restorative resins
(2026) Gündoğan, Zülal Çoban; Özyılmaz, Özgün Yılmaz; Kara, Özlem
Statement of problem: Subtractive manufacturing in computer-aided design and computer-aided manufacturing (CAD-CAM) systems has been extensively studied, but additive manufacturing materials, particularly those used for definitive restorations, are relatively new and data regarding their clinical performance remain limited. Purpose: This in vitro study aimed to evaluate the color stability of 3 different 3-dimensionally (3D) printed definitive restorative materials under 5 different Commission Internationale de l'Eclairage illuminants and to compare their metameric color differences. In addition, the mechanical wear resistance of these materials was evaluated independently. Material and methods: A total of 135 specimens with thicknesses of 1.0, 1.5, and 2.0 mm were 3D printed according to the manufacturers' protocols. Color was evaluated before and after thermocycling under 5 illumination conditions (D65, D50, A, F11, F2). ΔE00 values were analyzed using mixed-design analysis of variance (α=.05). Wear was evaluated in 2.0-mm specimens using simulated mastication and volumetric analysis, and the wear data were analyzed using the Kruskal-Wallis test (α=.05) RESULTS: All specimens exposed to illuminant A exhibited clinically unacceptable color changes, regardless of material type or thickness. Under illuminants D50, F11, and F2, color changes were perceptible but remained within clinically acceptable limits. Thermal aging significantly reduced ΔE00 values (P=.001). Although wear was observed in all groups, no significant differences were found in volumetric loss (P=.139). Conclusions: Illuminants significantly influenced color stability across all resin types and thicknesses, whereas increased restoration thickness was associated with reduced color change perceptibility. In addition, no significant differences in wear volume were found among the tested 3D-printed definitive restorative materials.
Endocrine and metabolism modulating effects of paracetamol: From in vitro signaling to in vivo metabolic reprogramming in male mice
(Elsevier, 2026) Entezari, Bita; Bozdağ, Deniz; Buhur, Aylin; Sabuncuoğlu, Suna; Yavaşoğlu, Altuğ; Orhan, Hande Gürer
Obesity is a major global health challenge associated with a cluster of comorbidities, including metabolic syndrome and type 2 diabetes, necessitating a deeper understanding of the environmental factors contributing to this epidemic. This study investigated the in vitro adipogenic/lipogenic potential of paracetamol and its in vivo endocrine and metabolic modulating effects following prenatal exposure. Using the 3T3-L1 preadipocyte model, cells were exposed to paracetamol at physiologically relevant concentrations. Results demonstrated that paracetamol promoted lipid accumulation and upregulated G3PDH activity. Furthermore, low concentrations significantly increased the protein expression of key adipogenic regulators (PPARγ, C/EBPα, LPL, and SREBP1), suggesting interference with transcriptional cascades governing adipogenesis and lipogenesis. To assess in vivo effects, pregnant CD1 mice were exposed to paracetamol at three human relevant doses (Cmax/10, Cmax, and Cmax×10). In male F1 offspring, prenatal exposure resulted in increased anogenital distance and a higher incidence of sperm morphological abnormalities, indicating reproductive developmental alterations despite unchanged circulating hormone levels. Metabolically, offspring exhibited dyslipidemia characterized by elevated serum triglycerides and total cholesterol. Although body weight and glucose tolerance remained unaffected, lipidomic profiling of epididymal adipose tissue revealed pronounced remodeling, including the accumulation of neutral lipids and altered membrane phospholipid composition. This was accompanied by the upregulation of the adipogenic genes Pparγ, Lpl, and Fasn in adipose tissue. Collectively, these findings suggest that paracetamol may act as an endocrine modulator and metabolic disruptor when exposed prenatally, inducing latent metabolic dysregulation that may predispose offspring to metabolic syndrome later in life, even in the absence of overt obesity
