İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Are sacral stress fractures in young women truly rare? a retrospective MRI analysis of 1970 patients
(BMC, 2026) Bayram, Yusuf; Doğan, Selman; Yalvaç, Bestami; Aksoy, Süleyman Hilmi; Karataş, Muhammed Enes
Background Sacral stress/insufficiency fractures (SSFs) are underrecognized causes of postpartum low-back/pelvic pain and are frequently misattributed to lumbar disc disease. To determine the MRI-based detection rate and clinical/ imaging characteristics of SSFs in women aged 18–50 years undergoing lumbosacral MRI, with subgroup analyses for postpartum versus non-postpartum status. Methods Retrospective review of 2400 lumbosacral MRI examinations (January 2020–December 2024) corresponding to 1970 unique women. SSFs were identified by a fellowship-trained musculoskeletal radiologist. Prespecified exclusions (chronic corticosteroid use, major pelvic trauma, incomplete follow-up) yielded the analytic cohort. Group comparisons reported effect sizes (Hedges’ g for continuous; risk difference [RD]/odds ratio [OR] for binary) with 95% CIs. Results Crude MRI-based detection rate: 1.52% (30/1,970; 95% CI, 1.07–2.17); analytic MRI-based detection rate: 1.17% (23/1,970; 95% CI, 0.78–1.75). Median age 34 years (range 22–49); 10/23 (43.5%) postpartum. Five cases (21.7%) were initially misdiagnosed. Fractures most often involved the sacral ala (right 12, left 10, bilateral 1). Compared with non-postpartum patients, postpartum patients had lower hemoglobin (**11.5 vs 12.6 g/dL; p = 0.007; Hedges’ g = 1.21, 95% CI 0.34–2.09) and hematocrit (**33.9% vs 37.3%; p = 0.007; g = 1.21, 95% CI 0.34–2.09); vitamin D was lower but nonsignificant (**15.4 vs 20.3 ng/mL; p = 0.204; g = 0.53, 95% CI − 0.28–1.34). Overall vitamin D status (n = 21): deficient < 20 ng/mL 11/21 (52.4%), insufficient 8/21 (38.1%), sufficient ≥ 30 ng/mL 2/21 (9.5%). The reported frequency reflects an MRI-based detection rate within a selected cohort of symptomatic women undergoing lumbosacral MRI and should not be interpreted as the true population prevalence of sacral stress fractures. Conclusion Sacral stress fractures in young women, particularly in the postpartum period, may be underrecognized in symptomatic patients presenting with persistent lo
The relationship between income inequality and energy poverty in the context of sustainable development goals: A micro-instrumental variables estimation in Türkiye
(Elsevier, 2026) Günay, Simge; Kayacan, Bekir; Uçal, Meltem
Energy poverty has adverse consequences on individuals’ lives. It endangers their health, interrupts their education, and may even undermine equality both within and between them. Since income inequality remains a significant problem on the path to achieving sustainable development in Türkiye, identifying its determinants on a micro scale is of great importance. In this regard, this study analysed the relationship of energy poverty to personal income inequality in Türkiye, utilising the TurkStat 2017-2020 income and living conditions survey micro-panel dataset. Instrumental variables estimation was used, and robustness checks were applied to achieve this aim. According to this, energy poverty is negatively related to personal income inequality. To check for heterogeneity, this relationship was re-examined within three income groups. The findings suggested that while energy poverty is positively related to personal income inequality at the bottom of the income distribution, it is negatively related to personal income inequality at the top of the income distribution. This study mainly contributes to the literature by providing the first micro-level evidence on the relationship between income inequality and energy poverty. A combination of targeted social and energy policies is required to tackle both energy poverty and income inequality on the micro scale in Türkiye.
Effects of adjuvant propofol on antitumoral effects of carboplatin in experimental endometrial cancer: possible epigenetic associations
(2026) Gürel, Çevik; Kuşçu, Gökçe Ceren; Buhur, Aylin; Dizakar, Saadet Özen Akarca; Kara, Hale Güler; Özateş, Neslihan Pınar; Yıldırım, Nuri; Günüşen, İlkben
Endometrial cancer (EC) is a gynecological malignancy classified into two biologically distinct subtypes, Type I and Type II EC. The more aggressive Type II EC exhibits a poor response to conventional platinum-based chemotherapy. Propofol, an anesthetic agent in gynecologic surgery, has been reported to exert antitumor effects beyond anesthesia; however, its role as a chemoadjuvant in EC remains insufficiently explored. In this study, we investigated the effects of propofol combined with carboplatin on drug resistance- and metastasis-associated microRNAs and genes using in vitro and in vivo Type II EC model. Propofol treatment significantly reduced cancer cell viability and migratory capacity, while the combination treatment showed greater antimetastatic effects compared with carboplatin alone. In xenograft models, combination therapy resulted in a significant reduction in tumor volume and suggested reduced metastatic involvement in lung and liver tissues. Molecular analyses revealed downregulation of oncogenic microRNAs (miR-21, miR-135a) and upregulation of tumor-suppressive microRNAs (miR-34b, miR-98), accompanied by reduced mTOR, c-Myc, MRP7, and N-cadherin expression and increased PTEN and HMGB1 levels. Collectively, these findings indicate that propofol is associated with greater antitumor effects when combined with carboplatin, accompanied by changes in miRNA-gene expression patterns.
Stress distribution in titanium and zirconia implants with full-arch prostheses: a finite element analysis
(2026) Saz, Bahattin; Özyılmaz, Özgün Yusuf; Özyılmaz, Özge Doğanay
Objective: The stress distribution and mechanical properties of materials used in dental implants are critically important for implant success and long-term stability. The aim of this study was to evaluate the stress distribution on implant, prosthetic system, and peri-implant tissues when titanium and zirconia implants are used with different framework materials using three-dimensional finite element analysis (FEA). Methods: A three-dimensional edentulous maxilla model was reconstructed from computed tomography data, and twelve finite element models were subsequently developed based on this anatomy to represent different implant and framework configurations. Within the scope of the study, titanium and zirconia implants were modeled in combination with cantilevered and noncantilevered prosthesis types and Co-Cr, PEKK, and zirconium framework materials. An oblique static load of 200 N was applied at a 45° angle in the palato-buccal direction to the central fossa of the first molar on the models. The Von Mises and principal stress distributions in the implant, abutment, screw, framework, and peri-implant bone were examined. Results: The highest Von Mises value was recorded in the cantilevered PEKK framework zirconia implant model (378.388 MPa). Compared with the Co-Cr and zirconium framework, the PEKK framework resulted in higher Von Mises stresses and greater prosthesis displacement. The presence of a cantilever increased stress levels in all framework materials, and stress concentrations were observed particularly in posterior abutments and peri-implant bone. Furthermore, stress values in trabecular bone were recorded above the physiological threshold level in the cantilevered PEKK framework models. Conclusions: Although zirconia implants exhibited greater stress than titanium implants, they remained within safe limits. Rigid framework materials and cantilever-free designs provide more balanced biomechanical results.
The Role of Boron in the Diet and as a Dietary Supplement
(2026) Kuru Yaşar, Hülya; Yarat, Ayşen
Boron is a naturally occurring trace element that has historically received limited attention in human nutrition and is of increasing biological importance. It is widely found in nature, primarily through food and drinking water, and has attracted attention for its potential health benefits. Emerging evidence suggests that boron supplementation may support bone health, cognitive function, mineral and hormonal metabolism, the antioxidant defense system, body weight regulation, and inflammation reduction. This review examines the physiological roles, health, and clinical effects of boron, both through dietary intake and supplementation. Although not currently classified as an essential nutrient, boron appears to be biologically important, and it is thought that supplementation may have positive effects on many health conditions, including osteoporosis, osteoarthritis, body weight regulation, cancer prevention and treatment, diseases associated with oxidative stress, neurological and mental disorders, and hormonal imbalance.
