İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Is Spirulina safe in terms of heavy metals? A public health risk assessment
(Springer Nature, 2026) Yaşar, Rüya Kuru; Aytekin, Özlem Üstün; Yılmaz, Şahin; Şahin, Fikrettin
Spirulina is a microalga/cyanobacterium widely consumed as a dietary supplement due to its high nutrient content and health benefits. While Spirulina is recognized for its contribution to daily mineral intake (e.g., iron, manganese, magnesium, and potassium), its ability to bind heavy metals raises safety concerns, particularly for vulnerable age groups. This study analyzed eight commercial Spirulina supplements (powder and tablet forms) consumed in Türkiye for heavy metal and macro-mineral content using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). The health risks were assessed across various age groups, including pregnant and breastfeeding women. Significant variability was found in heavy metal and mineral concentrations among the supplements, with one sample (S3) exceeding acceptable Hazard Index (HI) levels for all age groups except adults. Notably, Spirulina supplements generally did not exceed the established dietary reference values or Codex limits for heavy metals, except in certain younger age groups where potential non-carcinogenic risks were observed. The results emphasize the importance of determining safe consumption levels for Spirulina and other algae-based supplements to mitigate risks while maximizing their nutritional benefits. Additionally, the findings highlight the need for public health guidelines to standardize Spirulina’s daily intake and labeling practices.
The relationship between health literacy, nutrition literacy, and beliefs and behaviors related to cancer prevention
(2026) Baş, Dilşat; Schoinas, Ezgi Sakar; Kestane, Vahibe Uluçay
Purpose The study evaluates the relationship between cancer prevention beliefs and health and nutrition literacy, and their impact on healthy eating practices. Methods A cross-sectional study was conducted with 811 voluntary adult participants aged 18 to 65. Data were collected via a five-section questionnaire assessing sociodemographic characteristics, cancer prevention beliefs, Mediterranean Diet Adherence Scale (MEDAS), Turkish Health Literacy Scale-32 (TSOY-32), and Self-Perceived Food Literacy Scale (SPFL). Correlations between participants’ mean scores across the scales were analyzed. Results The mean age of participants was 27.02 ± 10.14 years. Mean scores were 32.01 ± 10.86 for health literacy, 4.00 ± 1.71 for MEDAS, and 89.94 ± 15.46 for SPFL. Fatalistic beliefs about cancer prevention were held by 71.3% of participants. Adequate health literacy and high adherence to the Mediterranean diet were independent variables that increased fatalistic cancer prevention beliefs (p < 0.05), while being over 30 reduced them. Higher education level, perception of health status, adequate nutrition knowledge, and receiving nutrition information from healthcare professionals or dietitians increased health literacy (p < 0.05). Being married, following a special diet, and higher perceived food literacy increased adherence to the Mediterranean diet (p < 0.05). Female gender, regular exercise, and higher perception of health status increased perceived food literacy (p < 0.05). Conclusion Improving health literacy, education level, perception of health status, and nutrition knowledge, along with ensuring health information from professionals such as dietitians, is essential for enhancing fatalistic beliefs about cancer prevention.
Dimensional and cross-sectional compatibility of contemporary nickel–titanium files and their corresponding gutta-percha cones: A micro-computed tomography study
(Springer International Publishing, 2026) Sarkan, Cem; Haznedaroğlu, Faruk
This study aimed to evaluate the dimensional and sectional compatibility between contemporary nickel–titanium (NiTi) root canal instruments and their corresponding gutta-percha (GP) cones with variable tapers, and to assess their compliance with ISO and ADA standards using micro-computed tomography (Micro-CT). Four NiTi file systems (ProTaper Next X2, HyFlex EDM OneFile, Reciproc Blue R25, and WaveOne Gold Primary) were analyzed. Their compatibility with corresponding GP cones was assessed based on diameter and taper measurements at 1 mm intervals (D1 to D16). Measurements were performed using Micro-CT imaging, and data were analyzed using descriptive statistics, independent t-tests, and one-way ANOVA with Bonferroni post hoc tests (p<0.05). Compliance with International Organization for Standardization (ISO) and American Dental Association (ADA) standards was also assessed. The findings reveal significant dimensional discrepancies between files and GP cones, with GP cones generally exhibiting larger diameters. Reciprocating systems (WaveOne Gold and Reciproc Blue R25) demonstrated superior compatibility with GP cones compared to rotary systems (ProTaper Next and HyFlex EDM OneFile). GP cones adhered more closely to ISO and ADA standards than files. Significant mismatches were identified between NiTi instruments and their corresponding GP cones. Reciprocating systems showed better dimensional compatibility than rotary systems. These results highlight the need for careful evaluation of material pairing to ensure optimal clinical performance.
Video-Based Physical Exercise Effects on Young Adults in Social Isolation During the Coronavirus Pandemic
(2023) Çırak, Yasemin Burak; Işıkcı, Burcu; Kardeş, Kübra; Tütüneken, Yunus Emre; Yelvar, Gül Deniz Yılmaz; İnal, Habibe Serap
Aim: The aim of this study is to evaluate the effectiveness of video-based exercises on the physical activity levels of individuals between the ages of 18-40 in social isolation to prevent the spread of the COVID-19 pandemic. Method: 64 volunteers participated as the control and 64 study groups were divided randomly and equally into two groups, the video-based exercise group (VEG) and the control group (CG). The video-based exercise group was included in an exercise program for 20 minutes, 7 days a week for 6 weeks. The primary outcome measure was the International Physical Activity Questionnaire (Short Form) (IPAQ-SF). Secondary outcome measures were the Nottingham Health Profile (NHP), Pittsburgh Sleep Quality Index (PSQI), Beck Anxiety Inventory (BAI), Distress Tolerance Scale (DTS), sit and reach test, shoulder flexibility test, squat test, plank test, lateral bridge test (LBT), crunch test and single leg stance test (SLST). Tests were applied to the groups at the beginning and the end of the study. Results: There was a statistically significant difference in all parameters in the study group before and after the application (p<0.05). According to the intergroup comparisons, there was a statistically significant increase between the groups in IPAQ-SF, Sit and Reach Test, Push Up Test, Plank Test, LBT, and SLST Tests; there was a statistically significant decrease between the groups in DTS, BAI, PSQI, and NHP scores (except for pain and social isolation scores) (p<0.05). Conclusion: Our findings will shed light on the management of the physiotherapy and rehabilitation process by contributing to the increasing evidence in the literature on the effectiveness of video-based exercises and improving health-related multifaceted parameters in various post-pandemic situations where access to health services and preventive rehabilitation is restricted.
Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model
(2026) Gürel, Çevik; Tut, Ezgi; Kuşçu, Gökçe Ceren; Buhur, Aylin; Germiyan, Özgün Selim; Leila Sabour-Takanlou; Maryam Sabour-Takanlou; Güler, Cem; Yavaşoğlu, Nefise Ülkü Karabay; Oltulu, Fatih; Yavaşoğlu, Altuğ
Parkinson's Disease (PD) is a prevalent neurodegenerative disorder. Recent studies implicate BRCA1-/BRCA2-containing complex 3 (BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study aimed to evaluate the therapeutic potential of BRCC3 silencing via systemically administered siRNA-loaded niosomes in a rotenone-induced rat model of PD. Niosomes were synthesised by thin-film hydration, and three BRCC3-targeted siRNA sequences were tested in primary midbrain dopaminergic neurons. The most effective sequence, identified by Real-Time Quantitative PCR (RT-qPCR) and immunofluorescence, was used for in vivo studies. The PD model was induced in adult male rats (n = 24/group) by subcutaneous rotenone administration (2 mg/kg/day) for 35 days. In the in vivo phase of the study, behavioural, biochemical, in vivo imaging (IVIS), histological, and RT-qPCR analyses were performed. IVIS analysis confirmed brain accumulation of niosome-siRNA complexes within 3-5 h. Complementary analyses demonstrated that siRNA treatment significantly enhanced locomotor performance, restored redox homeostasis and dopamine levels, attenuated neuronal loss, upregulated autophagy-related proteins (↑LC3-II, ↑Beclin), suppressed endoplasmic reticulum stress markers (↓GRP78/Bip, ↓CHOP), elevated tyrosine hydroxylase expression, and reduced α-synuclein accumulation. In conclusion, siRNA-mediated suppression of BRCC3 via siRNA-loaded niosomes provides neuroprotection by modulating autophagy, ER stress, and antioxidant pathways, supporting BRCC3 as a promising therapeutic target for PD.
