Meslek Yüksekokulu Koleksiyonu
https://hdl.handle.net/20.500.12941/16
2024-03-28T12:08:06ZEfficacy of pentosan polysulfate treatment in patients with interstitial cystitis/bladder pain syndrome
https://hdl.handle.net/20.500.12941/171
Efficacy of pentosan polysulfate treatment in patients with interstitial cystitis/bladder pain syndrome
Arıkan, Mehmet Gürkan; Çakıroğlu, Basri
Objectives: Pentosan Polysulfate (PPS) is the only oral treatment for interstitial cystitis (IC)-bladder pain syndrome (BPS) approved by the World Health Organization. Self-evaluation scales can provide more objective results on pre- and post-treatment satisfaction. The aim of this study was to investigate the effect of pentosan polysulfate treatment on symptoms in IC-BPS patients.
Methods: This study included 37 adult male and female patients with IC-BPS who reported pain, urinary urgency, polyurea, and nocturia without urinary tract infection for a minimum of six months prior to the study and were taking 300 mg/day oral pentosan polysulfate. Pre- and post-treatment symptoms, Interstitial Cystitis Symptom Index (ICSI) Scores, quality of life (QoL) scores (1-4), and satisfaction conditions were examined.
Results: Following the application of inclusion and exclusion criteria, mean age of 37 suitable patients was 46.0±11.9 years and 27% (10 individuals) of the patients were male. Pre-treatment, ICSI scores, and measures of satisfaction degree and QoL increased significantly after the treatment (p<0.001). Adverse reaction was detected in two patients (5.4%) among the patients treated with pentosan polysulfate.
Conclusions: Oral pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome treatment could achieve recovery in symptoms, increase Interstitial Cystitis Symptom Index score and improve quality of life and patient satisfaction.
2023-01-01T00:00:00ZMinimally invasive connective water vapor energy method for benign prostatic hyperplasia
https://hdl.handle.net/20.500.12941/170
Minimally invasive connective water vapor energy method for benign prostatic hyperplasia
Çakıroğlu, Basri
The Rezum system has emerged as a promising treatment option for benign prostatic hyperplasia (BPH) by employing endoscopic removal of prostate tissue. This meta-analysis aimed to evaluate the benefits and drawbacks of Rezum therapy in recent studies. A systematic literature search was conducted in EMBASE, PubMed, and the Cochrane Library databases until December 2021, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search utilized keywords such as water vapor thermal therapy, Rezum, convective water vapor thermal therapy, and convective radiofrequency water vapor thermal therapy. A total of 21 studies were included in the analysis, comprising 5 prospective randomized studies, 2 case series, 2 randomized controlled trials, 1 crossover study, and 11 retrospective studies. The collective sample involved 2090 patients with a mean follow-up period of 14.42 +/- 18.08 (1-72) months and a mean age of 68.12 +/- 4.79 years. Significant improvements were reported in the International Prostate Symptom Score (IPSS), quality of life (QoL), maximal flow rate (Qmax), postvoid residual urine volume (PVR), prostate volume (PV), and International Erectile Index Function (IIEF) values. Unlike other BPH treatments that often require general or regional anesthesia, the connective water vapor energy system can be administered with sedo-analgesia and local anesthesia, potentially leading to improved sexual function scores. Considering the relief of symptoms, Rezum therapy may serve as a viable alternative to transurethral surgery for patients with prostate volumes ranging from <30 to >80 cc.
2023-01-01T00:00:00ZThe importance of hematological parameters in the prognosis of patients with severe COVID-19, a single-center retrospective study
https://hdl.handle.net/20.500.12941/157
The importance of hematological parameters in the prognosis of patients with severe COVID-19, a single-center retrospective study
Gözüküçük, Ramazan; Kilic, Hassan Huseyin; Uyanık, Bekir Sami; Çakıroğlu, Basri
Background: Inflammation biomarkers known as acute phase reactants (APRs) show significant variations in serum concentrations during inflammation brought on by both viral and noninfectious diseases. The erythrocyte sedimentation rate (ESR), the C-reactive protein (CRP), the lactate dehydrogenase (LDH), the ferritin, the fibrinogen, the procalcitonin, the D-dimer, and the troponin I are all significant APRs. During inflammation, the serum levels of each of these positive APRs rise. The sensitivity and specificity of hematologic parameters and indices are as high as the inflammatory biomarkers mentioned above for monitoring disease severity and treatment response. Aim: We aimed to evaluate the differences in hematological parameters and indices, and to reveal their treatment and prognostic values, especially in deceased patients with COVID-19. Materials and Methods: The hemogram parameters of 169 critical patients with COVID-19 (125 males and 44 females) who received inpatient treatment at …. between 1 March 2020 and 31 December 2021 were analyzed retrospectively. The patients were divided into two groups—deceased (77) and surviving (92)—noting demographic data such as age and gender. All analyses were performed using SPSS 25.0. Results: Analyses of the hematological parameters used during the treatment processes revealed statistically significant differences between the two patient groups. White blood cell (WBC), neutrophil, and neutrophil to lymphocyte ratio (NLR) values were significantly higher (P = 0.019, P = 0.000 and P = 0.000, respectively) for deceased subjects, while lymphocyte, platelet and plateletcrit (PCT) values were significantly lower (for all values, P = 0.000). Platelet volume (MPV) and platelet distribution width (PDW), as well as MPV/PLT, PDW/PLT, MPV/PCT, and PDW/PCT, levels were significantly higher in deceased subjects (P = 0.000). Particularly in our deceased cases, receiver operating characteristic analyses were performed to reveal the importance of such analyses in prognostic status evaluation in COVID 19 since the hematological parameters are quite different. Cut off values were determined for each parameter, and sensitivity and specificity ratios were calculated. While the sensitivities of MPV/PLT, PDW/PLT, MPV/PCT, and PDW/PCT indices are over 80%, neutrophil and white blood cell sensitivities were found to be lower (74%, 68.8%, respectively). Conclusion: In addition to NLR, which is an important biomarker, the hematological indices MPV/PLT, PDW/PLT, MPV/PCT, and PDW/ PCT can be used to determine the risk of death in patients with severe COVID-19.
2023-01-01T00:00:00ZPreparation and characterization of carbopol based hydrogels containing dexpanthenol
https://hdl.handle.net/20.500.12941/148
Preparation and characterization of carbopol based hydrogels containing dexpanthenol
Çağlar, Emre Şefik; Karaotmarli Güven, Gökçe; Üstündağ Okur, Neslihan
Objective: The purpose of this study is to create dexpanthenol-loaded hydrogel formulations to alter the release patterns and enhance the physicochemical qualities of the market product. Material and Method: To make hydrogel formulations, Carbopol Ultrez was utilized in concentrations of 1%, 1.5%, and 2% (w/w). The active component dexpanthenol was then added to the formulations at a concentration of 5% (w/w). pH, viscosity, texture profile analysis, spreadability, bioadhesion, and in vitro release characteristics were all assessed for the formulations. Result and Discussion: The formulations were found to be suitable for cutaneous application. TPA analysis revealed that the G1 and G1-DXP formulations had the hardness value 10.1851.219 and 30.8541.637 g, respectively. That formulations’ bioadhesion strength has grown because they are more flexible than previous formulations while having low hardness values. As such, it has been observed that the formulations release more than 50% of DXP in three hours while the market preparation was not even reach the 10% drug release. In the in vitro release kinetics study, it was calculated that all formulations fit the Higuchi model. As a result, a more effective drug delivery system has been developed compared to the market preparation. The currently prepared formulations are also promising formulations in terms of their use in treatment.; Amaç: Bu çalışmanın amacı, salım modellerini değiştirmek ve piyasa ürününün fizikokimyasal özelliklerini geliştirmek için dekspantenol yüklü hidrojel formülasyonları oluşturmaktır. Gereç ve Yöntem: Hidrojel formülasyonları yapmak için, %1, %1.5 ve %2 (a/a) konsantrasyonlarında Carbopol Ultrez kullanıldı. Aktif bileşen dekspantenol daha sonra formülasyonlara %5 (a/a) oranında ilave edildi. Formülasyonlar için pH, viskozite, doku profili analizi, yayılabilirlik, biyoadezyon ve in vitro salım özelliklerinin tümü değerlendirildi. Sonuç ve Tartışma: Formülasyonların cilt uygulaması için uygun olduğu bulundu. TPA analizi, G1 ve G1-DXP'nin formülasyonların düşük sertlik değerinin sırası ile 10.1851.219 ve 30.8541.637 g sahip olduğunu ortaya koydu. Bu formülasyonların biyoadhezyon mukavemeti, önceki formülasyonlardan daha esnek oldukları ve düşük sertlik değerlerine sahip oldukları için arttı. Geliştirilen formülasyonlar ilk üç saatte %50’nin üzerinde DXP salımı gözlenirken piyasa preparatı %10’un üzerine bile çıkamamıştır. İn vitro salım kinetiği çalışmasında tüm formülasyonların Higuchi modeline uyduğu hesaplanmıştır. Sonuç olarak piyasadaki ürünlere göre daha etkin bir ilaç salım sistemi geliştirilmiştir. Halihazırda hazırlanan formülasyonlar, tedavide kullanımları açısından da umut vadeden formülasyonlardır.
2023-01-01T00:00:00Z