İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Salvia argentea L. extract inhibits the production of NO, and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), alleviates the inflammatory response of LPS-induced macrophages cells, and reduces the CRP level on carrageenan-induced paw edema
(Springer Science and Business Media Deutschland GmbH, 2025) Alhamedi, Almonther; Demiroz Akbulut, Tugce; Baykan, Sura; Gümüştaş, Barış; Sanci, Ebru; Alsakini, Karrar Ali Mohammed Hasan; Nalbantsoy, Ayşe; Yavasoğlu, Altuğ; Karabay Yavasoğlu, N. Ülkü
Salvia argentea L. (Lamiaceae) is a medicinal plant originating from the Mediterranean region and has been used since ancient times for the treatment of various diseases. This study aimed to determine the phytochemical composition of S. argentea L. ethanol extract and to evaluate its in vitro and in vivo anti-inflammatory activity and its acute oral toxicity. The chemical constituents of the ethanol extract prepared from the aerial parts of the plant were identified using HPLC. The in vitro anti-inflammatory activity of the extract was evaluated in LPS-stimulated murine macrophage RAW 264.7 cells and the human monocytic cell line THP-1 by measuring the levels of nitric oxide (NO), pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Acute toxicity of the extract was assessed in accordance with OECD guideline no 423. In vivo anti-inflammatory activity was evaluated based on the inhibition of 1% carrageenan-induced paw edema in rats. Serum CRP levels as an inflammatory marker, were measured via ELISA. Histological and immunohistochemical assessments were performed to identify tissue changes in the paw. HPLC profiling revealed that the extract contained rosmarinic acid (11.334 µg/mg dry extract), and salvigenin (2.74 µg/mg of dry extract) as major compounds. The extract significantly inhibited the production of NO, IL-1β, IL-6, and TNF-α without affecting cell viability. In vivo, the extract treatment exhibited a dose-dependent reduction in paw edema and serum CRP levels, along with notable histological improvements. Administration of the extract resulted in dose-dependent decreases of NF-κB expressions in the paw tissues. No signs of acute toxicity were observed (oral LD₅₀ > 2000 mg/kg). These findings suggest that S. argentea L. ethanol extract possesses significant anti-inflammatory potential supporting its possible development as a natural therapeutic agent for inflammatory disorders.
From unmet childhood needs to parenting attitudes: breaking the cycle
(Taylor and Francis, 2025)
Objective: Rooted in Schema Therapy, this research posits that unmet physiological, social, and psychological needs during early life contribute to the development of enduring cognitive frameworks, termed early maladaptive schemas (EMS), which influence affect, behaviour, and cognition across the lifespan. Accordingly, the objective was to examine whether EMSs are systematically associated with specific parenting attitudes (PAs). Method: This correlational study employed a concurrent design. Participants included 246 volunteer parents of preschool-aged children residing in a cosmopolitan district of Istanbul. Data were collected online using validated measures of EMS and PA, along with additional items assessing potential confounding variables. Results: Correlational analyses revealed moderate positive associations between EMS and authoritarian parenting attitudes and moderate negative associations with democratic parenting attitudes. Hierarchical regression analyses showed that EMS accounted for over 20% of the variance in parenting attitudes, with socioeconomic status and education emerging as significant moderators. Discussion: EMSs significantly predict parenting attitudes, increasing authoritarian attitudes, and reducing democratic ones. Early identification of EMS, combined with schema-focused interventions and evidence-based parent education programs may help disrupt maladaptive parenting cycles and promote healthier parent–child dynamics.
Representation of the City in Cinema: An Analysis of Kars Architecture as a Film Setting
(Ataturk Universitesi, 2025) Öztürk, Sezer Volkan
Due to cinema’s utilization of architecture as a filming location, the collaboration that has developed between these two disciplines has enabled the historical heritage of cities to be reflected on the silver screen. In this way, large audiences have become familiar with these cities through cinematic representation. As a border city that has experienced numerous occupations over time, Kars possesses a rich architectural, historical, and cultural background. These features have attracted the attention of many directors and screenwriters, and the city has taken on an almost leading role in several significant films. In this study, the ability of cinema to combine visuality and narrative has been examined through the spatial representation of the city of Kars in film. To analyze Kars’s cinematic representation from a multifaceted perspective and to obtain comparable data, a scene-content analysis was conducted on three films selected via a random sampling method. The spatial settings in these selected films were analyzed semiotically, focusing on their visual and symbolic meanings. Through this approach, the interaction between the city and its cinematic representation over time has been explored. Ultimately, the elements conveyed indirectly to the viewer constitute the foundation of semiotics, forming codes whose meanings are gradually interpreted by the audience. These codes, as presented through the films, contribute to the construction of a collective subconscious that reflects either an authentic or fictionalized image of the city and its society. As a result, the locations where films are shot are marketed either positively or negatively, intentionally or unintentionally. The findings of the analysis reveal that in the selected films, Kars is commonly represented through a rural narrative framework and is employed not as a realistic urban setting but rather as a fictionalized cinematic space.
-
Sinemanın mimarlığı bir çekim mekânı olarak kullanması nedeniyle bu iki disiplin arasında gelişen işbirliği; şehirlerin sahip olduğu tarihsel mirasın beyaz perdeye yansımasına, bu da çok sayıda insanın bu şehirleri sinema yoluyla kolayca tanımasına sebep olmuştur. Kars’ın sınır şehri olması ve yıllar içerisinde çok sayıda işgale uğraması sebebiyle şehrin mimarisi, tarihi ve kültürü zenginliklerle doludur. Bu zenginlikler günümüzde çok sayıda yönetmen ve senarist tarafından ilgi çekici bulunmuş ve şehir değerli birçok filmde adeta bir başrol oyuncusu gibi yer almıştır. Bu çalışmada, sinema sanatının sahip olduğu görseli ve anlatıyı bir araya getirme becerisi; Kars şehrinin sinemadaki temsili üzerinden okunmuştur. Kars'ın sinemadaki temsiliyetini çok yönlü inceleyebilmek ve karşılaştırabilir veri elde edebilmek adına; rastgele örnekleme yöntemiyle seçilen üç film üzerinden sahne-içerik analizi yapılmış ve film mekanları göstergebilimsel olarak incelenmiştir. Seçili filmlerdeki bu mekânların görsel ve sembolik anlamları, Kars'ın sinema sanatındaki temsili üzerinden okunarak yıllar içerisinde şehirle nasıl bir etkileşimde bulunduğu irdelenmiştir. Sonuçta dolaylı olarak seyirciye hissettirilen öğeler göstergebilimin temelini oluştururken seyircinin aslında ne anlama geldiğini zamanla kavradığı kodları meydana getirmektedir. Filmler ile verilen bu kodlar şehre ve topluma ait doğru veya kurgulanmış bir ortak bilinçaltı oluşturmaktadır. Neticede sinemanın çekildiği mekân olumlu veya olumsuz anlamda pazarlanmış olmaktadır. İncelenen filmlerde Kars şehri için kırsal bir anlatım dilinin ortak olarak tespit edildiği ve şehrin sinema mekânı olarak gerçek değil, kurgusal olarak kullanıldığı sonucuna varılmıştır.
The Effects of a Novel Nanohydroxyapatite Gel and Er: YAG Laser Treatment on Dentin Hypersensitivity
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Deger, Ceren; Oglakci, Burcu; Demirkol, Metehan; Kucukyildirim, Bedri Onur; Gursel, Mehtikar; Eliguzeloglu Dalkilic, Evrim
Purpose: This study evaluates the effects of a novel nanohydroxyapatite gel and Er: YAG laser on the surface roughness, surface morphology, and elemental content after dentin hypersensitivity treatments. Methods: Dentin discs (2 × 3 × 3 mm3) were prepared from 75 human molars. Out of 75 human molars, 50 were used to evaluate surface roughness and randomly divided into five groups: Group ID (intact dentin), Group DD (demineralized dentin), Group BF (fluoride varnish/Bifluorid 10), Group Lsr (Er: YAG laser-50 mJ, 0.50 W, 10 Hz), and Group NHA (nanohydroxyapatite-containing gel). Dentin hypersensitivity was stimulated by 35% phosphoric acid for 1 min (except Group ID). The surface roughness (Ra, μm) was measured via contact profilometry (n = 10). Out of the 75 sound human molars, 25 were used to evaluate the surface morphology and elemental content using scanning electron microscopy and energy-dispersive X-ray spectroscopy (n = 5). The data were statistically analyzed using Welsch ANOVA, Games–Howell, Kruskal–Wallis, and Dunn tests (p < 0.05). Results: Group Lsr showed significantly lower surface roughness than Group NHA and Group BF (p < 0.05). The SEM analysis indicated that most of the dentinal tubules were obliterated for Group NHA. Precipitant plugs with partially occluded dentinal tubules were observed for Group BF, while partially or completely occluded tubules with a melting appearance were detected for Group Lsr. The EDS analysis revealed that Group NHA and Group Lsr presented similar calcium and phosphorus amounts to Group ID. All dentin hypersensitivity treatment methods could provide promising results in terms of tubular occlusion efficiency. However, laser treatment resulted in smoother surfaces, which could help prevent dental plaque accumulation.
Online learning self-efficacy beliefs predict subjective well-being of college students during COVID-19 pandemic
(Journal of Educational Technology and Online Learning, 2024) Güçlü, Merve; Draganović, Selvira
Online learning self-efficacy is associated with significant psychological outcomes among college students. Nevertheless, research investigating self-efficacy among college students during COVID-16 pandemic is limited. The aim of the present study was to investigate the role of self-efficacy beliefs regarding online learning in predicting subjective well-being of college students. One hundred sixty-five college students were recruited for the study. Participants completed the Online Learning Self-Efficacy Scale (OLSES), the Subjective Well-Being Scale (SWBS), and a socio-demographic information form, which included items related to COVID-19 anxiety and the perceived impact of COVID-19 on daily life. Regression analyses showed that overall self-efficacy predicted subjective well-being scores. However, only the time management subdimension of self-efficacy significantly predicted subjective well-being. Our findings suggest that high levels of self-efficacy, particularly in time management, are associated with elevated levels of subjective well-being among college students. Interventions targeting self-efficacy in online learning environments may benefit college students with lower levels of subjective well-being during the COVID-19 pandemic.
