İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Knowledge and Attitudes of Dental Patients Toward Botulinum Toxin Treatment
(2025) Dede, Merve; Özyetim, Esra Bilgi
Background: This study aims to evaluate the knowledge, attitudes, and perceptions of patients applying to a dental faculty for treatment regarding botulinum toxin. Methods: The study was conducted at the İstanbul Yeni Yüzyıl University Faculty of Dentistry Hospital and included a total of 139 patients. A 3-section questionnaire was used: (1) demo?graphic data, (2) knowledge of Botox, and (3) attitudes toward Botox applications. The data were analyzed using IBM SPSS 23.0, and the Kruskal-Wallis test, Dunn’s test, Mann-Whitney U test, Chi-square test, and Fisher’s Exact tests were applied. Results: Among the participants, 67.6% were female, 32.4% were male, and 70.6% were between 18 and 44 years old. Only 15.1% of the participants correctly answered the ques?tion “What Is Botox?.” While 75.5% of the participants stated that Botox is used for cosmetic purposes, their knowledge of its therapeutic applications was limited. Additionally, 20.9% of participants reported being aware of the side effects of Botox, while 33.1% stated that they had considered undergoing Botox treatment. 12.9% of the participants had previously undergone Botox procedures, with 72.2% receiving it for aesthetic reasons and 27.8% for medical purposes. Conclusion: The results of the study indicate that patients have insufficient knowledge regarding the therapeutic uses of botulinum toxin. Participants predominantly perceive Botox as a cos?metic procedure and have limited awareness of its medical benefits. Furthermore, a significant portion of participants believe that Botox procedures can only be performed by plastic surgeons and dermatologists, demonstrating low awareness of the competency of dentists in administer?ing such treatments. This study highlights the need to increase patient awareness regarding both the aesthetic and therapeutic uses of Boto
Anatomical Relationship of the Mylohyoid Ridge, Lingual Concavity, and Mandibular Canal: A Retrospective CBCT Study
(MDPI, 2023) Şen, Selva; Girit, Melike Nur; Ansen, Gamze; Pençe, Kadriye Betül; Yüzbaşıoğlu, Neslihan
This study aimed to determine the position of the mylohyoid ridge (MR) and lingual concavity (LC) in the mandible and their relationship with the mandibular canal (MC) and submandibular fossa, to provide anatomical guidance for surgical procedures in this region. Methods: A retrospective analysis was performed on cone beam computed tomography (CBCT) scans from 200 adult patients who had undergone imaging for dental treatment. On cross-sectional images at the level between the first and second molar roots, the following measurements were obtained: LC horizontal depth, LC height, LC depth, MR height, MR depth, and the distances from MR to MC (MR–MC) and LC to MC (LC–MC). Results: Mean values were: LC horizontal depth: 3.72 ± 0.90 mm, LC height: 11.74 ± 2.01 mm, LC depth: 12.54 ± 3.03 mm, MR height: 17.66 ± 2.60 mm, MR depth: 6.87 ± 2.38 mm, MR-MC: 8.30 ± 2.00 mm, and LC-MC: 3.72 ± 0.87 mm. All parameters were symmetrical between the right and left sides of the mandible, with no significant sex differences. The positions of the MR and LC were related to each other, and the position of the MC was related to the positions of the LC and MR. There was no correlation between the horizontal depth of the LC and the position of the MR, LC and MC. Conclusions: The vertical positions of the MR and LC are related to each other and MC. Therefore, it can be used as a landmark in implant surgery.
Automated deep learning detection of orthodontically induced external apical root resorption in maxillary incisors on panoramic radiographs
(2026) Özden, Samet; Kula, Betül; Tankuş, Mahmut
Objectives This study aimed to develop and compare two YOLOv12-based deep learning models—object detection and pose estimation—for the automatic classification of orthodontically induced external apical root resorption (OIEARR) using panoramic radiographs. Materials and methods A total of 624 panoramic radiographs obtained from 312 patients aged 10–18 who underwent at least 12 months of fixed orthodontic treatment were retrospectively analyzed. Each maxillary central and lateral incisor was graded for OIEARR severity on a 4-point scale (Grade 0 to Grade 3) by two experienced orthodontists serving as the ground truth. Two YOLOv12-based models were trained: an object detection (OD) model for regional analysis and a pose estimation (PE) model for anatomical landmark localization. Both models were trained and validated on annotated panoramic images and evaluated using accuracy, precision, recall, specificity, F1-score, confusion matrix, and ROC-AUC. Results The PE model outperformed the OD model across all evaluation metrics, demonstrating superior performance in detecting OIEARR. Specifically, the PE model achieved a weighted F1-score of 0.88, compared to 0.60 for the OD model. It also showed higher accuracy (0.93 vs. 0.78), precision (0.88 vs. 0.64), and recall (0.88 vs. 0.59), confirming its robustness in root resorption classification. Particularly in Grade 1 and Grade 2 resorption categories, the PE model demonstrated markedly superior classification performance (F1=0.85 and 0.88, respectively), while maintaining excellent detection in Grade 3 cases (F1=0.95). Confusion matrix analysis revealed that most misclassifications occurred between neighboring grades. ROC-AUC values for the PE model were consistently high (0.90–0.99), indicating strong discriminative ability across all resorption stages. Conclusions The YOLOv12x PE model offers a reliable and sensitive tool for detecting varying degrees of root resorption on panoramic radiographs. Its fine-grained anatomical localization capabilities provide an advantage for early diagnosis, making it a promising approach for clinical decision support in orthodontics.
Does knee joint proprioception differ according to age and gender in healthy adults?
(2026) Kürklü, Galip Bilen; Yapalı, Gökmen; Arslan, Serdar; Çankaya, Musa
Background: This study aimed to investigate the effects of age and gender on knee joint position sense (KJPS) and movement sense (KJMS) in healthy adults. Methods: General physical activity was evaluated using the International Physical Activity Questionnaire-Short Form (IPAQ-Sf) and the Tegner Activity Scale (TAS). Knee discomfort was measured with the Lysholm Knee Score (LKS), and knee-related symptoms and functional status were assessed using the Knee Osteoarthritis Outcome Score (KOOS). Knee joint position sense (KJPS) was tested at 15°, 30°, 45°, and 60°, while knee joint movement sense (KJMS) was evaluated at 60° and 90°. Participants were categorized by gender (male, female) and age (18-29, 30-44, ≥ 45 years). Mixed-effects models were applied to analyze numerical data, and post hoc comparisons were conducted using least-squares means with Tukey's correction when appropriate. Results: The mean scores were KOOS = 96.41 ± 4.79, LKS = 96.41 ± 6.94, and IPAQ-Sf = 1772.02 ± 1332.10. Absolute errors for KJPS angles ranged from 2.58 to 3.42 between genders. KJMS at 60°-90° was measured between 1.82 and 1.95 s in males, and between 1.66 and 1.80 s in females. Significant differences in KJMS (60°-90°) were observed across age groups (F = 14.841, p < 0.001) and position-sense angles (F = 19.645, p < 0.001). Conclusion: KJPS assessment revealed significant differences in absolute errors by age and gender. Males demonstrated lower errors, while participants aged ≥ 45 years exhibited greater deviations than younger groups. No gender differences were identified in KJMS. Overall, proprioception declined significantly in the 45+ age group.
CD44 Targeting of Cisplatin-Loaded Hyaluronic Acid-Modified Mesoporous Silica Nanoparticles for Lung Adenocarcinoma: Synthesis, Characterization, In Vitro and In Vivo Evaluation
(2026) Güler, Cem; Gelen, S. Sacide; Şancı, Ebru; Buhur, Aylin; Tıkır, H. Ece; Nalbantsoy, Ayşe; Güner, Adem; Medine, E. İlker; Yavaşoğlu, Altuğ; Odacı, Dilek; Yavaşoğlu, N. Ülkü Karabay
Background/Objectives: Cisplatin (CDDP) is widely used in the treatment of non-small cell lung cancer (NSCLC); however, its clinical efficacy is limited by severe systemic toxicity. Hyaluronic acid (HA) modification enables the targeting of CD44-overexpressing cancer cells, enhances biocompatibility, provides controlled drug release, and prolongs systemic circulation. This study aimed to develop high-molecular-weight hyaluronic acid-modified, cisplatin-loaded mesoporous silica nanoparticles (HA-MSN-CDDP) to selectively target CD44- overexpressing lung adenocarcinoma cells. Methods: HA-MSN-CDDP nanoparticles were synthesized via the sol–gel method and characterized by FTIR, DLS, SEM, and TEM methods. Antitumor efficacy was evaluated using both in vitro and in vivo xenograft lung cancer models in mice. Results: HA modification enabled controlled and sustained release of cisplatin from the HA-MSN-CDDP drug delivery system. Through HA-mediated receptor-dependent endocytosis, the nanoparticles exhibited enhanced cellular uptake and selective cytotoxicity toward CD44-positive cells. HA-MSN-CDDP significantly reduced the cytotoxic, genotoxic, and oxidative stress effects of free cisplatin on healthy cells while markedly enhancing apoptosis in A549-Luc-C8 cells. The system showed excellent hemocompatibility, supporting its potential for intravenous use. In vivo, HA-MSN-CDDP effectively suppressed tumor growth, mitigated lipid peroxidation, and preserved antioxidant enzyme activities (SOD and CAT) in major organs. Histological analyses confirmed reduced cisplatin-induced nephrotoxicity. Conclusions: HA-MSN-CDDP demonstrates strong potential as a targeted chemotherapeutic platform for NSCLC, combining high antitumor efficacy with reduced systemic toxicity
