İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Malocclusion as a Cause of Temporomandibular Joint Disorders
(2025) İşçi, Kemal Devrim
The jaw and skull are joined at the temporal mandibular joint (TMJ), a synovial joint. You can find these two joints directly in front of your ears. Each joint comprises the mandibular condyle, the temporal bone’s articular tubercle, and an articulating disk. Allowed motions include lateral, vertical, and horizontal movement, protrusion, and retrusion. The complex motions of chewing, speaking, and generating facial emotions are made possible by this joint and the muscles that link to it. The joint pain and dysfunction that affect the jaw joint are known as temporomandibular disorders (TMDs) or TMJ syndrome. Myalgias, myofascial pain, arthralgia, disk displacement disorders, degenerative joint disease, subluxation, and 11 other pain-related and intra-articular TMJ diseases have been found by an international group. © 2025 Springer Nature Switzerland AG.
Treatment of a Class II, Division 1 Malocclusion and Ectopic Canines with Invisalign Mandibular Advancement and the Bootstrap Technique
(2025) Taslan Ceylanoğlu, Sinem; Ceylanoğlu, Cenk; Alcan, Toros
In a growing patient, a Class II, division 1 malocclusion is often treated by inducing supplementary mandibular growth with functional appliances. As Toth and colleagues reported, the correction is achieved through a combination of normal growth and mandibular skeletal and dento alveolar changes. 1 The proportion of skeletal to dental effects is determined by the timing of treatment,2, 3 the mode of mandibular advancement,4, 5 and the type and rigidity of the appliance.3, 6-8 © 2025 JCO, Inc.
Effect of solvent use on dentin crack in retreatment
(2024) Zümrütel, Pelin; Haznedaroğlu, Faruk; Keleş, Ali; Basmacı, Gülsüm Kutlu
AIM or PURPOSE: The aim of this study was to evaluate the effect of solvent use on dentinal crack formation in during root canal retreatment with micro-CT. MATERIALS and METHOD: Root canal treatments were performed on the mesial roots of 20 mandibular molars. The teeth were divided in two groups: Group A: solvent and Group B: Non-solvent. During primary treatment, canal preparation was performed using Revo-S files. The root canals were filled using the lateral compaction technique and AH Plus sealer. During retreatment procedure, Protaper Retreatment Files were used in both groups. Guttasolv was used as solvent during retreatment in group A. Before and after the initial treatment and retreatment, the teeth were imaged using microCT. Meanwhile, the remaining root canal filling materials in the teeth were also examined. RESULTS: Crack formation was not observed in either group. Residual filling material remained in the root canal after the procedure in both groups and there was no statistical significant difference found in terms of residual matter between the regions according to the results of the measurements made separately in three regions as coronal, middle, and apical regions. CONCLUSION(S): In conclusion, within the limitations of this in vitro study, it could be said that Ni-Ti systems do not cause dentin defects if used with or without a solvent. Even if the retreatment was performed close to ideal, it was determined that residual filling material remained on the canal walls during retreatment.
Qraypen In Residual Caries Detection And Cavity Disinfection
(2025) Bittar, Ahmad; Alkan, Elif; Tağtekin, Dilek
Introduction: Residual bacterial activity after selective caries removal may compromise restoration longevity. QrayPen, a fluorescence-based device, enables real-time detection of red fluorescence (DR) and maximum red fluorescence (DRmax)— markers of bacterial activity. This case series explores QrayPen’s utility in identifying residual caries and evaluating the antibacterial effect of 2% chlorhexidine digluconate applied as a cavity disinfectant. Case description: Five adult patients with active dentinal caries underwent selective caries removal. QrayPen was used to measure DR and DRmax before and after chlorhexidine application. Measurements were standardized in a dark environment with consistent drying and probe positioning. Lesions were also evaluated using ICDAS II, Nyvad criteria, and ICCMS radiographic scores. All five cases showed detectable fluorescence post-caries removal; post-disinfection readings indicated reduced bacterial activity. Discussion: The findings suggest QrayPen can identify residual bacterial presence undetectable by conventional visualtactile methods. The observed decrease in DR and DRmax values after chlorhexidine application supports its effectiveness as an adjunctive diagnostic tool. This dual use may enhance decision-making in minimally invasive restorative protocols by confirming both cleanliness of the cavity and efficacy of disinfection. Conclusion/clinical significance: QrayPen may aid clinicians in verifying caries removal and evaluating cavity disinfection in real time. Its integration into routine practice could support more conservative and evidence-based restorative treatments, improving long-term outcomes.
Mitochondrial Dynamics‑Related Gene Regulation by Epigenetic Suppression of GCN5 Exerts Neuroprotective Effects in Rotenone‑Induced Parkinson’s Disease Model
(2026) Kuşçu, Gökçe Ceren; Tut, Ezgi; Gürel, Çevik; Buhur, Aylin; Germiyan, Özgün Selim; Avcı, Çığır Biray; Güler, Cem; Şancı, Ebru; Yavaşoğlu, Nefise Ülkü Karabay; Yavaşoğlu, Altuğ
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and mitochondrial dysfunction. Recent studies implicate the histone acetyltransferase GCN5 in regulating mitochondrial homeostasis and oxidative stress. This study investigated the therapeutic potential of GCN5 silencing via systemically administered siRNA-loaded niosomes in a rotenone-induced rat model of PD. Niosomes were prepared using the thin-film hydration method, and the most effective siRNA sequence was selected through real time quantitative PCR (RT-qPCR) and immunofluorescence in primary mesencephalic neurons. Adult male rats were divided into four groups (n=24/group), and PD was induced with rotenone (2 mg/kg/day, s.c., for 35 days). Behavioral assessments, biochemical analyses, IVIS imaging, histopathology, immunohistochemistry, and RT-qPCR were conducted. IVIS confirmed brain accumulation of siRNA– niosomes within 3–5 h post-injection. GCN5 siRNA treatment significantly improved locomotor activity (p<0.05), decreased MDA levels (p<0.05), and restored SOD and dopamine levels (p<0.05). Molecular findings showed decreased GCN5 and mitochondrial fission-related gene Drp-1 expression, increased expression of mitophagy and biogenesis markers (↑Parkin, ↑PINK1, ↑Mfn2, ↑PGC-1α), elevated TH expression, and reduced α-synuclein accumulation. Histological analysis revealed preserved midbrain cytoarchitecture and reduced neuronal damage. In conclusion, these findings highlight that epigenetic silencing of GCN5 via siRNA-loaded niosomal delivery provides neuroprotection in PD by modulating the expression of genes involved in mitochondrial dynamics, offering preclinical support for its development as a novel therapeutic strategy.
