İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
CD44 Targeting of Cisplatin-Loaded Hyaluronic Acid-Modified Mesoporous Silica Nanoparticles for Lung Adenocarcinoma: Synthesis, Characterization, In Vitro and In Vivo Evaluation
(2026) Güler, Cem; Gelen, S. Sacide; Şancı, Ebru; Buhur, Aylin; Tıkır, H. Ece; Nalbantsoy, Ayşe; Güner, Adem; Medine, E. İlker; Yavaşoğlu, Altuğ; Odacı, Dilek; Yavaşoğlu, N. Ülkü Karabay
Background/Objectives: Cisplatin (CDDP) is widely used in the treatment of non-small cell lung cancer (NSCLC); however, its clinical efficacy is limited by severe systemic toxicity. Hyaluronic acid (HA) modification enables the targeting of CD44-overexpressing cancer cells, enhances biocompatibility, provides controlled drug release, and prolongs systemic circulation. This study aimed to develop high-molecular-weight hyaluronic acid-modified, cisplatin-loaded mesoporous silica nanoparticles (HA-MSN-CDDP) to selectively target CD44- overexpressing lung adenocarcinoma cells. Methods: HA-MSN-CDDP nanoparticles were synthesized via the sol–gel method and characterized by FTIR, DLS, SEM, and TEM methods. Antitumor efficacy was evaluated using both in vitro and in vivo xenograft lung cancer models in mice. Results: HA modification enabled controlled and sustained release of cisplatin from the HA-MSN-CDDP drug delivery system. Through HA-mediated receptor-dependent endocytosis, the nanoparticles exhibited enhanced cellular uptake and selective cytotoxicity toward CD44-positive cells. HA-MSN-CDDP significantly reduced the cytotoxic, genotoxic, and oxidative stress effects of free cisplatin on healthy cells while markedly enhancing apoptosis in A549-Luc-C8 cells. The system showed excellent hemocompatibility, supporting its potential for intravenous use. In vivo, HA-MSN-CDDP effectively suppressed tumor growth, mitigated lipid peroxidation, and preserved antioxidant enzyme activities (SOD and CAT) in major organs. Histological analyses confirmed reduced cisplatin-induced nephrotoxicity. Conclusions: HA-MSN-CDDP demonstrates strong potential as a targeted chemotherapeutic platform for NSCLC, combining high antitumor efficacy with reduced systemic toxicity
A Comparative Analysis of Initiatives Aimed at Enhancing Digital Health Literacy (DHL) on a Global Scale
(2025) Kolca, Dilek
This study aims to provide a comprehensive review of educational campaigns and projects designed to enhance DHL. The study was conducted as a systematic review. It comparatively evaluated the objectives, educational strategies, and outcomes of educational programs and projects related to DHL. Data were collected through literature searches in databases such as Scopus, PubMed, and Google Scholar. DHL projects and educational programs have significantly improved individuals’ access to and management of health information. These initiatives have not only enhanced individual health literacy but have also played a critical role in improving overall public health. The primary focus of DHL projects and educational programs is to increase the accessibility of digital tools and strengthen technological infrastructure. This focus aims to ensure sustainability and create long-term positive effects on public health literacy. The global dissemination of such initiatives could contribute to the sustainable development of public health.
Sağlık Turizmi Perspektifinden Türkiye Ve Hindistan’ın Sağlık Politikaları Ve Sosyal Güvence Sistemlerinin SWOT Analizi
(2026) Kolca, Dilek
Sağlık turizmi, dünya genelinde ekonomik kalkınmayı destekleyen stratejik sektörlerden biri haline gelmiştir. Türkiye ve Hindistan, son yıllarda geliştirdikleri politikalar ve sundukları hizmet çeşitliliği ile sağlık turizmi pazarında öne çıkan iki önemli aktör hâline gelmiştir. Her iki ülke de uygun maliyetli hizmetleri, nitelikli sağlık personeli ve turistik cazibesi ile uluslararası hastaların ilgisini çekmektedir. Ancak bu ülkelerin sağlık turizmine yönelik politika yaklaşımları ve sosyal güvence sistemleri, bazı yönleri ile farklılık göstermektedir. Bu çalışma, Türkiye ve Hindistan’ın sağlık turizmi politikaları ile sosyal güvence sistemlerini SWOT analizi yöntemiyle karşılaştırmalı olarak değerlendirmeyi amaçlamaktadır. Analiz sonucunda, Türkiye'nin kurumsal ve merkezi yapısı, gelişmiş sosyal güvence sistemi ve coğrafi avantajı güçlü yönlerini oluşturmaktadır. Ancak ülkede ikamet eden yabancı hastaların sosyal güvence kapsamına doğrudan dâhil edilememesi, bu seçimin kişilerin inisiyatifine bulunması Genel Sağlık Sigorta (GSS) sistemin kapsayıcı ve zorunluluk ilkelerine ters düşmektedir. Öte yandan, Hindistan’ın uygun maliyetli sağlık hizmetleri, geleneksel tıp uygulamaları ve medikal vize kolaylıkları sağlık turizminin gelişimine katkı sağlamaktadır. Hindistan’ın sosyal güvence sisteminin parçalı yapısı ve hizmet eşitsizlikleri ise önemli zayıf yönleri olarak öne çıkmaktadır. Her iki ülke açısından fırsatlar arasında dijital sağlık hizmetlerinin yaygınlaştırılması, uluslararası iş birlikleri ve alternatif tıp uygulamalarının küresel pazara entegrasyonu yer alırken, tehditler arasında hizmet kalitesi, sağlıkta yerli halkın erişim sorunları ve uluslararası rekabet dikkat çekmektedir. Çalışma, sağlık turizmi politikalarının sürdürülebilirliği için sosyal güvence sistemlerinin daha kapsayıcı ve eşitlikçi şekilde yapılandırılmasını önermektedir.
Individualized respiratory exercise device originated in Türkiye: design, prototype, and first results
(Tubitak Scientific & Technological Research Council, 2026) Cilbir, Çiğdem Emirza; Harputlu, Özge Ertan; Uçgun, Hikmet; Ekşi, Büşra Ülker; Kara, Sarper; Kıyan, Esen
Background/aim: Respiratory muscle training (RMT) and breathing exercises are crucial components in cardiopulmonary rehabilitation. RMT includes inspiratory muscle training (IMT) and expiratory muscle training (EMT); however, existing RMT devices typically support only one of these. Incentive spirometers, which also provide visual feedback for breathing exercises, are frequently used. Achieving an RMT program requires multiple devices, which increases both the cost and complexity of the training regimen. This study aimed to design, calibrate, and test a novel individualized respiratory exercise device that integrates both IMT and EMT functions into a single unit, thereby offering a cost-effective, user-friendly alternative for comprehensive cardiopulmonary rehabilitation. Materials and methods: The design process involved a comparative analysis of existing RMT devices. A concept design was developed, followed by a three-dimensional-printed prototype. Calibration was performed using a pressure meter, with tests conducted on ten healthy volunteers across a range of inspiratory and expiratory pressures. Additionally, a pilot clinical study involving six healthy adults assessed the device’s impact on maximum inspiratory and expiratory pressures (MIP, MEP) and functional exercise capacity during an eight-week RMT period. Results: The internal consistency of the lowest (0.919) and the highest (0.841) levels of inspiration pressure, and of the lowest (0.901) and the highest (0.856) levels of expiration pressure, were highly reliable. Each healthy participant who completed the eight-week RMT program showed increases in MIP, MEP, and six-minute walking distance. Conclusion:The novel respiratory exercise device successfully combines IMT and EMT functions with an incentive spirometer, enabling comprehensive respiratory exercises and RMT within a single unit. Its ease of use and adaptability make it a promising option for both clinical and home-based rehabilitation, potentially improving accessibility and adherence to cardio
Analysis of caesarean section rates according to the Robson classification system and indications for caesarean delivery: experience from a tertiary health centre in Turkey
(BMC, 2026) Düzgüner, Soner; Sağır, Fulya Gökdağlı; Kale, İbrahim; Düzgüner, İpeknur Balin
Background Globally and in Turkey, caesarean section (CS) rates have risen steadily over recent decades, reflecting changes in clinical practice, maternal preference, medico-legal concerns, and healthcare system dynamics. The Robson Ten-Group Classification System, complemented by analysis of CS indications, provides a standardised and objective framework for identifying modifiable factors contributing to the increasing use of CS. This study aimed to evaluate CS rates in a tertiary healthcare centre in Turkey using the Robson classification in conjunction with specific clinical indications. Methods This retrospective observational study included all women who delivered at Umraniye Training and Research Hospital, Department of Obstetrics and Gynaecology, between 01 August 2018 and 11 September 2025. Data were obtained from the hospital’s electronic birth registry and categorised according to the Robson Ten-Group Classification System and indications for CS. Results During the study period, 25,767 births were recorded, of which 11,939 (46.4%) were delivered by CS. The most significant contribution to the overall CS rate originated from Robson Group 5 (23.8%), followed by Group 1 (5.2%). The most common indication for CS was previous uterine surgery, including prior CS and/or myomectomy (54.9%), followed by foetal distress (19.1%). Conclusion The overall CS rate in this study was 46.4%, with Robson Groups 5 and 1 accounting for the majority of procedures (29.0% combined). Previous uterine surgery and foetal distress were the predominant indications.
