İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Organizational and Individual Antecedents of Resistance to Change: Organizational Climate and Technology Readiness
(Sciendo, 2025) Eyitmiş, Ahmet Melih; Zümrüt, Muhammet Zeki
Background and purpose: There is interest in barriers to change in organizations. This research discusses factors affecting resistance to change based on employees’ technological competencies. This research aims to determine the mediating role of technology readiness in the effect of organizational climate in health institutions on resistance to change. Methodology: Research data were collected from 389 employees working in the healthcare sector. SPSS Process 2.13 macro was used to analyze the model. Results: According to the analysis results, organizational climate positively affected technology readiness. Additionally, organizational climate reduced resistance to change. In addition, employees’ readiness for technology reduced resistance to change. Finally, the mediating role of technology readiness (motivating and blocking factors) in the effect of organizational climate on resistance to change was significant. Further, a positive organizational climate in healthcare institutions increased employees’ readiness for new technologies and significantly reduced employees’ resistance to change. Conclusion: Creating a positive organizational climate can be vital in successfully implementing change processes in the healthcare sector. At the end of the research, theoretical and practical suggestions were presented. The research contributes to the literature by addressing the antecedents of resistance to change from organizational and individual perspectives.
Preparation and Characterization of Bigels from Psyllium Husk Seed Hydrogel–Beeswax Oleogel: As a Fat Replacer in Cakes
(American Chemical Society, 2025) Akcicek, Alican; Karasu,Salih
This study used PHP (psyllium husk seed powder) and BW (beeswax) to create a hydrogel and Oleogel for bigel production. The resulting bigels were utilized as a fat replacement in cake composition. Bigel manufacturing employed 5 and 10% PHP hydrogels and 7.5% BW Oleogel at various HG/OG ratios. Visual appearance results indicated that gelation was verified by inverting the samples in plastic tubes, which exhibited no flow under gravity. Also, the samples became bright yellow as the Oleogel proportion increased. Microscopy revealed that the bigel with a hydrogel/Oleogel volume ratio of 75:25 formed bicontinuous structures. Fourier transform infrared spectroscopy (FTIR) spectra of the Oleogel, hydrogels, and bigels showed no new peaks identified in the bigel samples with different fractions of Oleogel. The bigel samples showed that the G′ values were higher than the G″ values, indicating that the samples showed viscoelastic solid behavior. An increase in the Oleogel ratio in bigel samples led to improved viscoelasticity. The hydrogel ratio exhibited the highest thermal stability and a greater G′ value than the Oleogel, particularly at 5%-75 PHP and 10%-75 PHP across different temperatures. In addition, the hardness and chewiness values of bigel samples increased with hydrogel concentrations. The bigel stability result showed that the 10%-25 PHP had the lowest accelerated percolation rate, suggesting it was the most stable sample and retained more liquid. Cake samples created with palm oil, 5%-25 PHP, and 10%-25 PHP had a crumb structure with fine air cells evenly distributed. 10%-25 PHP and 5%-25 PHP cake samples showed the highest hardness values and no significant change with the control palm cakes (p 0.05). Furthermore, based on the ΔE value, 5%-50 PHP and 10%-25 PHP cakes had the least color change in the crust and the crumb of the cake. The 10%-25 PHP cake samples would be a better choice as they could be considered an alternative to palm oil in cake in terms of visual appearance, textural properties, and color properties.
Radiological analysis of palatal arterial anatomy for periodontal surgery: insights from 3D-RA
(Springer-Verlag Italia s.r.l., 2025) Bozay Oz, Evrim; Oz, Ibrahim Ilker
Objective: This study aimed to comprehensively evaluate the detailed arterial anatomy of the palatal mucosa, emphasising the greater palatine artery (GPA) and lesser palatine artery (LPA), through the use of three-dimensional rotational angiography (3D-RA). This detailed vascular analysis aims to inform clinical decisions and reduce the risk of vascular injury during palatal graft harvesting procedures. Methods: A retrospective analysis of radiological data was conducted on 80 consecutive patients who underwent cerebral or carotid digital subtraction angiography (DSA) incorporating 3D-RA imaging. Detailed measurements were obtained for the GPA, descending palatine artery (DPA), and LPA, including arterial diameters, branching patterns, and their spatial relationships with palatal mucosal thickness and vault morphology. Based on GPA and LPA branching patterns, the vascular supply to the hard palate was classified. Results: The GPA was classified into three branching patterns, with Type I (absence of medial branch) being most prevalent (65%), typically accompanied by the presence of LPA contributions to the medial hard palate. Type II (MB coursing anterior to the palatal spine) was identified in 23.75% of patients. Type III was present in 11.25%, The mean diameter of the GPA was 0.99 ± 0.16 mm, while the DPA was significantly larger in males (p = 0.036). The GPA’s lateral branch narrowed anteriorly, with the smallest mucosal-to-vessel distance measured at the first premolar region (2.55 ± 1.11 mm), indicating a heightened risk for surgical injury. No significant relationship was found between palatal vault morphology and mucosal thickness. Conclusion: The LPA contributed to medial hard palate perfusion in the absence of the GPA’s medial branch, indicating its surgical relevance in mucogingival procedures.
Balance and biomechanics: exploring lower extremity biomechanics in Parkinson’s disease
(Springer Science and Business Media Deutschland GmbH, 2025) Duzenli, Senanur; Gunduz, Merve Sevinc; Yilmaz, Aysen Elif; Erdal, Yuksel; Mustafaoğlu, Rüstem
Background: Postural instability (PI) is a symptom seen in 16% of Parkinson Disease (PD) patients and has limited response to dopaminergic therapy. Understanding the factors contributing to PI, such as biomechanical changes, is important for the development of non-pharmacological treatment. Aims: To investigate the relationship between lower extremity biomechanics and balance parameters in PD patients. Methods: A total of 18 participants (n = 9 female) were enrolled in the study. Lower extremity biomechanics were evaluated using a combination of measurements, including femoral anteversion angle, Q angle, leg length, navicular drop test (NDT), gastrocnemius shortness, range of motion (ROM) assessments, and the Foot Posture Index (FPI). Balance was assessed through the Postural Stability Test, Fall Risk Index (FRI), and the Mini-BESTest. Results: A significant correlation was observed between FRI and femoral anteversion (r = 0.58, p = 0.011) as well as hip flexion ROM (r = 0.67, p = 0.002) and lateral malleoli curvature (r = 0.48, p = 0.04). Overall Stability Index (OSI) was significantly associated with NDT (r = 0.53, p = 0.024) and forefoot abduction/adduction (r = 0.67, p = 0.002). The Anteroposterior Stability Index (APSI) correlated with NDT (r = 0.47, p = 0.048), knee flexion ROM (r = 0.47, p = 0.045), and forefoot abduction/adduction (r = 0.65, p = 0.004). Moreover, Mini-BESTest scores were associated with hip abduction (r = 0.55, p = 0.017), ankle plantar flexion (r = 0.63, p = 0.005), and knee flexion ROM (r = 0.47, p = 0.048). Conclusions: This study demonstrated that lower extremity biomechanical features, including alignment and joint mobility, are significantly linked to balance and fall risk in individuals with PD. Incorporating biomechanical assessments into clinical evaluations may aid in developing individualized treatment strategies for balance disorders in PD.
Clinical and molecular results in 15 Turkish patients with Wiedemann-Steiner syndrome: identification of eight novel KMT2A variants and a case of dual molecular diagnosis in the CSNK2A1
(Springer Science and Business Media Deutschland GmbH, 2025) Yeter, Burcu; Demirkol, Yasemin Kendir; Usluer, Esra; Oğuz, Sümeyra; Eser, Metin; Yarar, Murat Hakkı; Canbek, Sezin
Wiedemann-Steiner syndrome (WSS) is a rare autosomal dominant neurogenetic disorder caused by monallelic variants in KMT2A gene, characterized by neuromotor developmental delay, intellectual disability, microcephaly, seizures, behavioral disorders, dysmorphic facial features, hirsutism, and systemic anomalies. The KMT2A gene encodes a histone lysine methyltransferase crucial for the regulation of gene expression during early developmental stages. In this study, the clinical and molecular findings of 15 Turkish patients with WSS confirmed by whole exome sequencing are reported. Variant segregation was confirmed in all families. The ages of the patients were between 1.5 and 16 years. The majority of patients had neuromotor developmental delay, speech delay, and intellectual disability. The most frequently recognised dysmorphic facial features were thick eyebrows, long eyelashes, synophrys, hypertelorism, and broad nose. Other frequently observed clinical findings included short stature, congenital hypotonia, behavioral problems, genitourinary anomalies, and abnormal gait. Novel findings included focal segmental glomerulosclerosis, cholelithiasis, and sacrococcygeal teratoma. Fifteen different KMT2A variants were detected, including 8 novel (p.Gln3594*, p.Glu1407Argfs*4, p.Ser610Ilefs*9, p.Ser2188Leufs*25, p.Glu970Glnfs*37, p.Ser759Valfs*22, p.Lys1346Serfs*24, and c.11146 + 1_11146 + 6delinsA) variants. Additionally, one patient exhibited a dual molecular diagnosis with a de novo variant in CSNK2A1, associated with Okur-Chung neurodevelopmental syndrome. Conclusion: This study expands the clinical and molecular spectrum of WSS, highlighting novel variants and unique manifestations. It emphasizes the importance of molecular testing in accurate diagnosis and management. By characterizing phenotypic diversity and dual diagnosis, this work contributes valuable insights for advancing clinical care and guiding future research. (Table presented.)
