İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Malaria in Turkey: A comprehensive analysis of diagnosis, treatment, and the impact of COVID-19, ten years after malaria elimination (2012-2023)
(Elsevier Inc., 2025) Şahin, Özgün Ekin; Kalay, Zeynepgül; Sarı, Nagehan Didem; Batırel, Ayşe; Ersöz, Gülden; Tuncer, Ertem Günay; Turunç, Tuba; Gözüküçük, Ramazan; Şimşek Çelener, Funda; Kantürk, Arzu; Süer, Kaya; Özer Balın, Şafak; Sağmak Tartar, Ayşe; Çelebi, Güven; Kuşoğlu, Hülya; Ateş, Selma; Alkan, Sevil; Mıstanoğlu Özatağ, Duru; Berk, Hande; Uzun, Cengiz; Karakoç, Çağla; Erdem, İlknur; Mumcu, Necati; Çölkesen, Fatma; Altunçekiç, Arzu; İnci, Ayşe; Yılmaz Karadağ, Fatma; Türkoğlu Yılmaz, Emine; Arslan, Mustafa; Şahin, Ahmet; Erdoğan, Haluk; Zorbozan, Orçun; Ertabaklar, Hatice; Ertan, Oğuz; Gücer, Lal Sude; Ergönül, Önder
Background: The characteristics, diagnosis, and treatment stages of malaria in Turkey in the last
ten years are not known except few case reports. We aimed to describe the details of the
diagnosis and treatment practices of malaria cases in various hospitals across Turkey between
2012 and 2023 after the declaration of the elimination of malaria.
Methods: We collected the patient data from 30 centers by using Qualtrics Survey Software. The
patients were categorized according to the WHO Malaria Severe Disease Symptoms guidelines.
Results: We detected 299 malaria cases. Of these patients, 23.7% experienced misdiagnosis,
with 77.5% of misdiagnosed cases receiving antibiotics. Among the patients, 9 (3%) had no
travel history. Additionally, 28 (9.4%) patients required admission to the intensive care unit
(ICU) during hospitalization. There is a significant association between misdiagnosis and
subsequent ICU admissions. Additionally, the duration between malaria diagnosis and the
initiation of treatment significantly affected ICU admissions. Furthermore, the number of cases
with severe malaria (according to WHO criteria) and ICU admissions increased after the
COVID-19 period. In multivariate analysis, initial misdiagnosis was found to be associated with
ICU admission (OR: 2.8, p < 0.05), while each day's treatment delays post-diagnosis increased
ICU admissions (OR: 1.26, p < 0.05).
Conclusion: Misdiagnosis is common which delays the treatment and is correlated with higher
admissions to ICUs. Post-COVID-19, there was a notable increase in both ICU admissions and
cases of severe malaria, suggesting an escalation in disease severity that warrants further
investigation. The resurgence of rare malaria cases with no travel history to abroad highlights the
necessity of continued vigilance for new malaria cases. Efforts to promptly treat upon diagnosis
and improve diagnostic accuracy in Turkey, where malaria is uncommon, are crucial. Enhancing
diagnostic methods and treatment strategies remains essential, especially in significant events
like COVID-19.
Comparison of conventional and modified sling suture techniques in free gingival graft operations-a randomized controlled clinical trial
(BMC, 2025) Shakiliyeva, Sanubar; Şahin, Demet; Günpınar, Sadiye; Gursel, Mihtikar
Background: The aim of this study was to investigate the effects of conventional suture (CS) and modified sling suture (MSS) techniques, applied in free gingival graft (FGG) surgery using gingival unit graft (GUT) and conventional graft (CG) techniques, on clinical parameters and graft dimensions.
Methods: 52 individuals having Cairo Type 2 (RT2) and Type 3 (RT3) gingival recessions in mandibular anterior were divided into four groups as (a) GUT + MSS (n = 13), (b) GUT + CS (n = 13), (c) CG + MSS (n = 13) and (d) CG + CS (n = 13). Keratinized tissue width (KTW), relative gingival recession height (rGRH), and relative vestibule depth (rVD) measurements were recorded using a digital caliper and UNC 15 periodontal probe. Dimensional changes (Δ) of the graft surface area (GSA) was determined by ImageJ software. All measurements were done at baseline, 1st and 3rd months.
Results: It was determined that the increase in KTW in the 1st and 3rd months in GUT + CS group was significantly higher than GUT + MSS group (p < 0.05). There was no statistically significant difference in Δ rVD and Δ rGRH values between the groups. When ΔGSA (mm2) values were compared between the groups, the decrease in the 1st and 3rd months in the CG + MSS group was found to be significantly higher than the GUT + MSS and GUT + CS groups (p < 0.05).
Conclusion: Within the limits of this study, it can be concluded that keratinized tissue can be obtained successfully with both GUT or CG techniques in FGG surgery, on the other hand, regardless of the suture technique, GUT showed less graft shrinkage than CG.
Investigation of the effect of ultraprocessed food consumption on asthma using pulmonary function tests
(Sage Publishing, 2025) Özçalkap İçöz, Rümeysa; Alpaslan, Mehmet; Tural, Seda
Background: NOVA is a food classification system that classifies foods according to the scope and purpose of food processing, rather than nutrients. Asthma is usually characterized by chronic inflammation and respiratory symptoms such as wheezing, shortness of breath, chest tightness, cough, and variable expiratory airflow limitation. According to the NOVA food classification system, consumption of ultraprocessed foods (UPF) can affect asthma symptoms. Aim: In this study, the relationship between UPF consumption and pulmonary function test (PFT) results of asthma patients in adults aged 18 to 65 was investigated using biochemical parameters. Methods: This study was a cross-sectional study and, was conducted with 339 asthmatic participants diagnosed with asthma and receiving medical treatment. The participants' consumption of UPF was determined using a food frequency questionnaire. The evaluation of forced expiratory volume in one second (FEV1) (L/s) and forced vital capacity (FVC) (L/s) in the respiratory function tests was based on the percentage of the measured and expected values. Results: Although no significant relationship was found between % FEV1 expected value and UPF consumption (P > 0.05), it was concluded that % FVC expected and % FEV1/FVC values decreased with increasing UPF consumption (P < 0.05). Conclusion: It has been concluded that consumption of UPF worsens respiratory function and asthma prognosis. Therefore, replacing UPF and beverage products with healthier foods or food processing methods will play an important role in maintaining health.
Touching the Loss and Creating a New Sense of Being in Clay Field Therapy: A Longitudinal Phenomenological Research
(Halil Eksi, 2025) Başoğlu Yavuz, Saba
Clay Field Therapy is a trauma-informed Sensorimotor Art Therapy
rooted in haptic perception. It emphasizes the tactile relationship
between the individual’s hands and materials, providing a non-verbal
avenue for deep therapeutic processing. The combination of three
fundamental materials creates Clay Field: a rectangular wooden
box filled with smooth clay and warm water. This longitudinal
phenomenological study aims to examine the experiences of
individuals undergoing Clay Field Therapy to process complex grief.
The participant group consists of four women, aged between 30 and
45, who sought Clay Field Therapy due to their unique experiences of
loss and grief. Data was collected through participant-led, in-depth,
process-oriented, and semi-structured interviews conducted after the
first and twelfth Clay Field sessions of each participant. Longitudinal
Interpretative Phenomenological Analysis was employed to explore
in detail how participants attributed meaning to their experiences,
changes, and transformations during Clay Field Therapy. Four
superordinate themes emerged from the analysis of data: beyond
words, from nothingness towards existence, from tangible experiences
towards a transformative spiritual experience, and a comprehensive
sense of being. Clay Field Therapy facilitates not only the resolution
of the grief process but also enables profound existential work and
spiritual growth. This process, in which individuals reconstruct the
meaning of life through their tactile encounters in the Clay Field, has
been conceptualized as “Embodied Reflection.”
Functional changes in metabolic syndrome
(Metabolic Syndrome: A Comprehensive Update with New Insights, 2025) Gürler, Esra Bihter; Aras, Hülya Çevik; Bostanci, Nagihan
Metabolic Syndrome (MetS) is a condition characterized by the cooccurrence of several cardiovascular risk factors, including insulin resistance, obesity, dyslipidemia, and hypertension. The development of MetS is closely linked to visceral adiposity, which refers to fat accumulation around critical vital organs in the abdominal cavity. Visceral fat is metabolically active and produces adipokines, proteins that regulate energy balance and play a role in inflammation and atherosclerosis. Some adipokines, such as leptin and adiponectin, have beneficial effects on glucose homeostasis and are considered protective against MetS. However, other adipokines, such as visfatin and resistin, contribute to glucose intolerance and have pro-atherogenic properties. Visceral obesity also contributes to the development of MetS through its effects on blood pressure. It activates the sympathetic nervous system, the reninangiotensin-aldosterone system, and insulin resistance, leading to elevated blood pressure. Another critical factor in the development of MetS is the activation of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). LOX-1 is a protein that acts as a receptor for oxidized LDL on the cell surface. Its activation leads to the production of reactive oxygen species, a decrease in nitric oxide, and increased expression of molecules contributing to hypertension and vascular damage. LOX-1 is also involved in the development of other complications associated with MetS, such as nephropathy and left ventricular hypertrophy. The renin-angiotensin-aldosterone system (RAAS) regulates blood volume, electrolyte balance, and vascular resistance. In patients with MetS, the activation of RAAS leads to increased levels of angiotensin II (Ang II) and aldosterone, which have various effects on blood pressure and sodium and water retention. Ang II also contributes to oxidative stress and inflammation in the vasculature. Insulin resistance, a key feature of MetS, disrupts the insulin signaling process in adipose tissue, leading to increased lipolysis and elevated levels of circulating free fatty acids. These fatty acids further worsen insulin resistance and contribute to impaired glucose metabolism.Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and the body's antioxidant defenses, is closely associated with the development of MetS. Hyperlipidemia and hyperglycemia, standard features of MetS, are linked to increased oxidative stress and ROS production. Oxidative stress and the activation of RAAS and LOX-1 contribute to the progression of dyslipidemia, type 2 diabetes, hypertension, and cardiovascular diseases. The oral-gut-liver axis is an emerging concept that suggests a relationship between oral infections, such as periodontitis, and metabolic dysfunction, including MetS and liver diseases. Periodontitis has been associated with chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and liver cirrhosis. The translocation of oral bacteria from the mouth to the gut may contribute to gut dysbiosis, increased intestinal permeability, and systemic inflammation, which can worsen liver functions. Overall, the development of MetS involves the interplay of various factors, including visceral obesity, adipokines, LOX-1 activation, insulin resistance, oxidative stress, and the oral-gut-liver axis. Understanding these mechanisms is crucial for preventing and managing MetS and its associated complications. Further research is needed to fully elucidate the roles of individual factors and develop targeted interventions for MetS.
