İstanbul Galata Üniversitesi Kurumsal Akademik Arşivi
DSpace@Galata, İstanbul Galata Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Functional changes in metabolic syndrome
(Metabolic Syndrome: A Comprehensive Update with New Insights, 2025) Gürler, Esra Bihter; Aras, Hülya Çevik; Bostanci, Nagihan
Metabolic Syndrome (MetS) is a condition characterized by the cooccurrence of several cardiovascular risk factors, including insulin resistance, obesity, dyslipidemia, and hypertension. The development of MetS is closely linked to visceral adiposity, which refers to fat accumulation around critical vital organs in the abdominal cavity. Visceral fat is metabolically active and produces adipokines, proteins that regulate energy balance and play a role in inflammation and atherosclerosis. Some adipokines, such as leptin and adiponectin, have beneficial effects on glucose homeostasis and are considered protective against MetS. However, other adipokines, such as visfatin and resistin, contribute to glucose intolerance and have pro-atherogenic properties. Visceral obesity also contributes to the development of MetS through its effects on blood pressure. It activates the sympathetic nervous system, the reninangiotensin-aldosterone system, and insulin resistance, leading to elevated blood pressure. Another critical factor in the development of MetS is the activation of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). LOX-1 is a protein that acts as a receptor for oxidized LDL on the cell surface. Its activation leads to the production of reactive oxygen species, a decrease in nitric oxide, and increased expression of molecules contributing to hypertension and vascular damage. LOX-1 is also involved in the development of other complications associated with MetS, such as nephropathy and left ventricular hypertrophy. The renin-angiotensin-aldosterone system (RAAS) regulates blood volume, electrolyte balance, and vascular resistance. In patients with MetS, the activation of RAAS leads to increased levels of angiotensin II (Ang II) and aldosterone, which have various effects on blood pressure and sodium and water retention. Ang II also contributes to oxidative stress and inflammation in the vasculature. Insulin resistance, a key feature of MetS, disrupts the insulin signaling process in adipose tissue, leading to increased lipolysis and elevated levels of circulating free fatty acids. These fatty acids further worsen insulin resistance and contribute to impaired glucose metabolism.Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and the body's antioxidant defenses, is closely associated with the development of MetS. Hyperlipidemia and hyperglycemia, standard features of MetS, are linked to increased oxidative stress and ROS production. Oxidative stress and the activation of RAAS and LOX-1 contribute to the progression of dyslipidemia, type 2 diabetes, hypertension, and cardiovascular diseases. The oral-gut-liver axis is an emerging concept that suggests a relationship between oral infections, such as periodontitis, and metabolic dysfunction, including MetS and liver diseases. Periodontitis has been associated with chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and liver cirrhosis. The translocation of oral bacteria from the mouth to the gut may contribute to gut dysbiosis, increased intestinal permeability, and systemic inflammation, which can worsen liver functions. Overall, the development of MetS involves the interplay of various factors, including visceral obesity, adipokines, LOX-1 activation, insulin resistance, oxidative stress, and the oral-gut-liver axis. Understanding these mechanisms is crucial for preventing and managing MetS and its associated complications. Further research is needed to fully elucidate the roles of individual factors and develop targeted interventions for MetS.
A physiotherapeutic approach to a baby with right disgenesis of thumb and left agenesis of upper extremity: A case report
(Prosthetics and Orthotics International, 2024) İnal, Habibe Serap; Reis, Osman
A boy with bilateral congenital anomalies of the upper extremities with transverse absence of the left arm (agenesis) and absence of right thumb (disgenesis), fixed elbow in extension due to humeroradial synostosis thought that the humerus was intact. His wrist could move passively with 50° flexion, 0° extension, and 70° radial deviation. The other 4 fingers were intact, 4-5 metatarsal bones were in synostosis, and the fifth finger was clinodactyly. He was born by normal delivery. The physiotherapist started sensorimotor training to achieve functional movements of the right upper extremity. The exercises for the trunk muscles were emphasized to prevent the future possible thoracolumbar curve due to the absence of loading of the left arm on trunk muscles. Serial splinting was performed to position the wrist and fingers for functional purposes and abduction and internal rotation of the index finger to perform the opposition position until the pollicization surgery. At 1 and a half, his trunk was straight, and the wrist was partially corrected (15° extension; 35° radial deviation). He was able to play with toys and eat food. The mother rated his performance as 8/10 and 10/10, respectively. Both mother and father were satisfied with his performance in activities of daily living according to his age compared with his peers (9/10; 10/10, respectively). Thus, the physiotherapist's sensorimotor training and the positioning splints may be considered as feasible interventions in this case.
Exploring Medium- and Long-Term Respiratory and Functional Sequelae in Young Adults Post-COVID-19
(MDPI, 2025) Ekşi, Büşra Ülker; Kısa, Eylül Pınar; Harputlu, Özge Ertan; Kara Kaya, Begüm; Hoşbay, Zeynep; Akıncı, Buket
Background and Objectives: Long COVID-19 syndrome may cause difficulties in functionality during daily life in young people. Our objective was to investigate the respiratory and functional sequelae in young adults with asymptomatic or mild COVID-19 compared with healthy peers 3-6 months and 6-12 months after COVID-19 infection. Materials and Methods: Participants aged 18-25 who had COVID-19 within the last 3-6 months (Post-COVID Group 1, n = 25) and 6-12 months (Post-COVID Group 2, n = 25) and age-gender-matched healthy controls (n = 25) were included in this study. Respiratory functions and muscle strength were measured. Physical function was assessed with 6 min walking test (6MWT) and an Incremental Shuttle Walk Test (ISWT). The 1 min sit-to-stand test (1-MSTST) and hand grip strength (HGS) were used to assess muscle performance. Fatigue and dyspnea severity were questioned. Results: The FVC%pred (p = 0.023) and MEP (p = 0.034) were higher, and 1-MSTST repetitions were lower in Post-COVID Group-1 compared to Post-COVID Group-2 (p = 0.029). The PEF%pred (p = 0.025), MEP (p = 0.001), and ISWT distance were lower in Post-COVID Group-2 compared to healthy controls. The number of 1-MSTST repetitions and 6MWT distance were lower in Post-COVID Group-1 (p = 0.003, p = 0.001) and Post-COVID Group-2 (p = 0.003, p = 0.017) than in healthy controls. Exercise-induced blood lactate change during the ISWT, HGS, fatigue, and dyspnea were not significantly different between post-COVID groups and healthy controls. Conclusions: Young adults who pass asymptomatic or mild SARS-CoV-2 infection exhibit a decline in FVC%pred, PEF%pred, lower extremity muscle performance, and physical function within 3-6 months. In addition, the deterioration in respiratory and physical functions becomes apparent within 6-12 months.
Determination of job stress levels of physical education and sport teachers
(Campus EDUCA SPORTIS S.L., 2025) Hergüner, Gülten; Yücel, Ali Serdar; Bal, Fatih; Özpınar, Saliha; Yaman, Çetin; Korkmaz, Murat; Kuyucu, Mihalis Michael
This study investigates how the job stress levels of physical education and sport teachers vary according to gender, age, educational status and job position. Within the scope of the research, the data obtained from 520 teachers were used and the job stress questionnaire was evaluated under four main subheadings. The results of Bartlett's test and Kaiser-Meyer-Olkin (KMO) coefficient for the suitability of the data for factor analysis showed that the data were quite suitable for factor analysis; while the workload sub-heading explained the highest variance with 26.7%, skill use explained 14.2%, decision freedom explained 12.03% and social support explained 11.6% of the total variance. In the analyses based on gender differences, it was determined that male teachers had higher levels of workload stress, while female teachers had higher levels of skill use, decision freedom and social support stress. In the analyses conducted between age groups, no significant differences were found in the sub-dimensions. Similar results were obtained in the analyses conducted according to education levels. In the analyses conducted according to job positions, it was determined that administrators did not differ from non-administrators in all dimensions. These results show that it is important to customise job stress management strategies according to gender, age and job positions. It is emphasised that general stress management strategies should be developed to cover all demographic groups. © 2025, Campus EDUCA SPORTIS S.L.. All rights reserved.
Online cognitive behavioral stress management program for breast cancer patients
(Nobel Ilac, 2024) Savaş, Esra; Keleş, Merve; Tin, Özlem
Objective: Breast cancer is a challenging process that affects the diagnosed people and their social environment psychologically, physiologically, socially, and economically. The main purpose of this study is to investigate the effectiveness of the Online Cognitive Behavioral Stress Management (CBSM) for Cancer program, which is structured for people diagnosed with cancer to develop coping methods that will enable them to cope with the stress they experience healthily and actively. The research question is whether attending the CBSM program is effective for the psychological well-being of breast cancer patients or not. Material and Method: The study was completed with a total of 35 people, 17 in the experimental group and 18 in the control group. The pretest-posttest results of the experimental and control groups were analyzed. The independent sample t-test was used in the comparison of the two groups of experimental and control groups. Paired sample t-test was used to compare the pretest-posttest scores of each group. Results: There was a significant difference observed between the experimental and control groups in the post-test measurements in terms of psychosocial adjustment to illness, assessment of coping attitudes, depression, hope, state, and trait anxiety (p<0.001). There was no significant difference in the pre-test and post-test scores of the experimental and control groups in terms of mental adjustment to cancer. Conclusion: The CBSM program for breast cancer patients is effective in coping with daily and illness-related stress by increasing psychological well-being: increased psychosocial adjustment, adaptation and decreased depression, and anxiety. © 2024, Nobelmedicus. All rights reserved.
