Efficacy of pentosan polysulfate treatment in patients with interstitial cystitis/bladder pain syndrome

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dc.contributor.authorArıkan, Mehmet Gürkan
dc.contributor.authorÇakıroğlu, Basri
dc.date.accessioned2023-12-21T12:11:17Z
dc.date.available2023-12-21T12:11:17Z
dc.date.issued2023
dc.departmentMeslek Yüksekokulları, Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractObjectives: Pentosan Polysulfate (PPS) is the only oral treatment for interstitial cystitis (IC)-bladder pain syndrome (BPS) approved by the World Health Organization. Self-evaluation scales can provide more objective results on pre- and post-treatment satisfaction. The aim of this study was to investigate the effect of pentosan polysulfate treatment on symptoms in IC-BPS patients. Methods: This study included 37 adult male and female patients with IC-BPS who reported pain, urinary urgency, polyurea, and nocturia without urinary tract infection for a minimum of six months prior to the study and were taking 300 mg/day oral pentosan polysulfate. Pre- and post-treatment symptoms, Interstitial Cystitis Symptom Index (ICSI) Scores, quality of life (QoL) scores (1-4), and satisfaction conditions were examined. Results: Following the application of inclusion and exclusion criteria, mean age of 37 suitable patients was 46.0±11.9 years and 27% (10 individuals) of the patients were male. Pre-treatment, ICSI scores, and measures of satisfaction degree and QoL increased significantly after the treatment (p<0.001). Adverse reaction was detected in two patients (5.4%) among the patients treated with pentosan polysulfate. Conclusions: Oral pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome treatment could achieve recovery in symptoms, increase Interstitial Cystitis Symptom Index score and improve quality of life and patient satisfaction.
dc.identifier.citationArıkan MG Çakıroğlu B. Efficacy of Pentosan Polysulfate Treatment in Patients with Interstitial Cystitis/ Bladder Pain Syndrome. Bladder 2023;10:e21200007. DOI: 10.14440/bladder.2023.866en_US
dc.identifier.doi10.14440/bladder.2023.866
dc.identifier.endpage6
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.14440/bladder.2023.866
dc.identifier.urihttps://hdl.handle.net/20.500.12941/171
dc.identifier.volume10
dc.indekslendigikaynakPubMed
dc.institutionauthorÇakıroğlu, Basri
dc.language.isoen
dc.publisherPol Scientific
dc.relation.ispartofBladder (San Franc)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBladder pain syndrome
dc.subjectEfficacy
dc.subjectInterstitial cystitis
dc.subjectPentosan polysulfate
dc.subjectTreatment
dc.titleEfficacy of pentosan polysulfate treatment in patients with interstitial cystitis/bladder pain syndrome
dc.typeArticle

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