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Öğe Correction: Dimensional and cross-sectional compatibility of contemporary nickel-titanium files and their corresponding gutta-percha cones: A micro-computed tomography study(2026) Şarkan, Cem; Haznedaroğlu, Faruk; Keleş, AliThis article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.Öğe Effect of different laser modalities and treatment methods on the surface roughness and alterations of 3D printed resins and PEEK: An in vitro study(Elsevier, 2026) Karabağlı, İrem Çelikyürek; Çopuroğlu, Akanay; Kayahan, Zeynep Özkurt; Özyılmaz, Özgün YusufStatement of problem The effects of laser irradiation, airborne-particle abrasion, and electrolytic cleaning on the surface roughness of 3-dimensionally (3D) printed resin and PEEK healing abutments remain unclear. Purpose The purpose of this in vitro study was to examine surface changes after different treatment methods were applied to the surfaces of the different 3D printed resin and PEEK materials used as custom healing abutments. Material and methods Disk-shaped specimens (3×10 mm) were fabricated from three 3D printed resins (VarseoSmile TriniQ, Saremco Print Crowntec, C&B Ceramic Resin) and PEEK (CopraPeek) (N=240). Specimens were assigned to 5 surface treatment groups: erbium-doped yttrium aluminum garnet (Er:YAG), neodymium-doped yttrium aluminum garnet (Nd:YAG), diode laser, airborne-particle abrasion, and GalvoSurge (n=48). Surface roughness (Ra) was measured at baseline (T0) and after treatment (T1). Representative specimens were examined using scanning electron microscopy (SEM). Data were analyzed using nonparametric tests (α=.05). Results Airborne-particle abrasion and Er:YAG significantly increased surface roughness in all groups (P<.05). The highest roughness was observed in the Crowntec–airborne-particle abrasion group (0.89 ±0.09 µm), and the lowest in the TriniQ–GalvoSurge group (0.09 ±0.02 µm). GalvoSurge caused no significant change in TriniQ and PEEK but increased roughness in C&B and Crowntec. Nd:YAG showed no effect in TriniQ and C&B but increased roughness in Crowntec and PEEK, while diode laser affected only Crowntec (P<.05). SEM analysis confirmed treatment-dependent surface morphology changes. Conclusions Surface treatments altered resin and PEEK surface properties. Airborne-particle abrasion and Er:YAG laser treatments resulted in the greatest increases in surface roughness, while GalvoSurge and diode laser treatments generally caused minimal or nonsignificant changes.Öğe Cross-Species Generalization and Comparative Performance Analysis of Deep Neural Network Architectures in Histological Image Classification(2026) Çelen, Kaan; Oltulu, Fatih; Çağlar, Buse; Buhur, Aylin; Kılıçarslan, Burak; Çolak, Burhan Berk; Yavaşoğlu, AltuğHistological image classification plays a critical role in biomedical research and diagnostic processes. Advances in the field of deep learning present significant opportunities for enhancing diagnostic accuracy and developing automated decision support systems. This study aims to comparatively evaluate the out-of-distribution generalization and cross-domain classification performance of different deep neural network encoders. In this study, models were trained on an internal dataset of 4307 hematoxylin and eosin (H&E) stained images of male rat lung, cerebellum, and adipose tissues, obtained under ethical committee approval (Ege University, HADYEK 2026-06). To evaluate genuine generalization, testing was conducted on a separate, diverse external cohort of 600 mixed human-and-animal images. Nine different deep learning architectures-MobileNetV3-S, MobileNetV3-L, DenseNet121, DenseNet201, ConvNeXt-S, ConvNeXt-B, DINOv3 ViT-S, DINOv3 ViT-H+, and the pathology foundation model UNI2-h-were evaluated using frozen feature extraction combined with a linear probe. For performance evaluation, accuracy, sensitivity, specificity, F1 score, Cohen's κ, and ROC-AUC metrics were analyzed along with per-image inference times. While all models achieved near-perfect results during internal cross-validation, their performance diverged significantly on the external dataset, confirming that the observed differences reflect genuine cross-domain generalization capabilities rather than under-fitting. All competitive models demonstrated high performance in classifying adipose and cerebellum tissues, achieving an F1 score of 95% or higher for these tissues. In distinguishing the lung tissue, which has the most diverse structure and is the most difficult to classify, the UNI2-h model emerged as the most successful, achieving an F1 score of 97.4% and a recall of 95.0%. When evaluated in terms of computational efficiency, the MobileNetV3-Small model stood out as having the lowest processing time among all scenarios, demonstrating an inferencÖğe Zafirlukast Exacerbates Behavioral Seizure Activity and Blood–Brain Barrier Disruption Despite Modestly Reducing Neuronal Injury Markers in a PTZ‑Induced Early Epileptogenesis Mouse Model(Springer, 2026) Görgülü, Volkan; Tomruk, Cansın Şirin; Ergün, Pelin; Özdil, Berrin; Sancı, Ebru; Buhur, Aylin; Sözmen, Eser Y.; Köse, Timur; Yavaşoğlu, Nefise Ülkü Karabay; Yavaşoğlu, AltayEpilepsy is one of the most prevalent neurological disorders worldwide, and approximately 25% of patients remain refractory to pharmacological treatment. Blood–brain barrier (BBB) disruption and reactive gliosis are key mechanisms implicated in early epileptogenesis. This study investigated the effects of zafirlukast, a leukotriene receptor antagonist, on BBB permeability, reactive gliosis, and behavioral seizure activity in a pentylenetetrazol (PTZ)-induced early epileptogenesis model in C57BL/6 mice. Zafirlukast was administered twice daily at a dose of 10 mg/kg. Seizure activity was evaluated by behavioral observation in terms of seizure severity, latency, duration, and frequency. BBB permeability was assessed using the Evans Blue assay, and brain tissues were analyzed by biochemical and immunohistochemical methods. The PTZ + ZAFIR group exhibited more severe seizures, characterized by increased seizure frequency and duration, shorter latency, and a higher kindling rate (80% vs. 27%). BBB permeability was also increased, whereas MMP-9 levels remained, suggesting disruption may be linked to direct mechanical effects of recurrent seizures rather than inflammation. Clues suggest that zafirlukast may exert paradoxical effects on two prominent cell types involved in reactive gliosis. While increased GFAP and TGF-β1 expression may reflect enhanced astrocyte activation, changes in IL-1β and Iba1 expression suggest suppression of microglial activation. Notably, pro-inflammatory and oxidative stress markers remained unchanged despite the increase in seizure severity. The observed reduction in neurodegeneration may be attributable to the suppressive effects of zafirlukast on microglial activation and the subsequent reduction in pro-inflammatory cytokine release. These findings indicate a complex role for leukotriene signaling during early epileptogenesis. Further studies using different doses, vehicles, and experimental models are warranted to clarify the effects of zafirlukast on the mechanisms underlying early epileptogenesis. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.Öğe Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice(Wiley, 2026) Entezari, Bita; Bozdağ, Deniz; İnce-Ergüç, Elif; Buhur, Aylin; Tomruk, Cansın Şirin; Sabuncuoğlu, Suna; Yavaşoğlu, Altuğ; Gürer, Orhan HandeParacetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/ metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long-term metabolic and reproductive consequences linked to intrauterine paracetamol exposure. Pregnant dams were administered paracetamol at three dose levels (Cmax/10, Cmax, and Cmax×10) during a critical window of organogenesis (gestational days 7.5–16.5). Offspring were monitored until 17weeks of age to assess growth, glucose homeostasis, lipidomic profiles, and ovarian histology. Prenatal exposure did not significantly affect total body weight but induced a dose-dependent increase in peritoneal adipose tissue mass, particularly in the Cmax×10 group. Metabolic assessments revealed impaired glucose tolerance in the Cmax/10 group and increased insulin sensitivity across all dose groups. Adipose tissue gene expression analysis demonstrated upregulation of adipogenic markers (Pparγ, Lpl, Fasn), while untargeted lipidomics revealed consistent dysregulation of lipid species, including lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), sphingomyelins (SMs), and triacylglycerols (TGs), indicating altered lipid storage and inflammatory signaling. Histological evaluation showed a marked reduction in total follicle number and increased follicular atresia following paracetamol exposure. Degenerative changes in oocytes and granulosa cells were observed, and multi-oocyte follicles (MOFs) were detected exclusively in the Cmax/10. Collectively, these findings demonstrate that intrauterine paracetamol exposure induces persistent developmental reprogramming in female offspring, characterized by visceral adiposity, disrupted lipid homeostasis, and depletion of the ovarian reserve. Notably, several endpoints exhibited non-monotonic dose–response relationships, underscoring the sensitivity of developing systems to even subtherapeutic paracetamol exposure.Öğe Asynchronous recovery of medial and lateral gastrocnemius mechanical properties and jump performance following localized plantar flexor fatigue(BMC, 2026) Şahbaz, Yasemin; İlez, Ali; Batur, NergizObjective: To investigate the acute and short-term (24 h) effects of localized plantar flexion fatigue on muscle mechanical properties, countermovement jump (CMJ) kinetics, and dynamic balance, focusing on recovery profiles of the gastrocnemius medialis (MG) and lateralis (LG). Design: Prospective, repeated-measures experimental study. Methods: Twenty-eight healthy volunteers (n = 28) performed a standardized unilateral isometric plantar flexion fatigue protocol until task failure (Borg CR-10 ≥ 8). Assessments were conducted at baseline, immediately post-fatigue, and 24 h post-fatigue (24 h). Outcomes included myotonometric properties (tone, stiffness, elasticity, relaxation time, and creep) of the MG and LG via MyotonPRO, CMJ kinetics via force plate, and dynamic balance via the Modified Star Excursion Balance Test (mSEBT). Results: Significant Time × Region interactions were found for stiffness (P = 0.038, ηp² = 0.276) and relaxation time (P = 0.024, ηp² = 0.171). Both muscle heads showed an acute decrease in stiffness (P < 0.001); however, LG stiffness recovered by 24 h (P = 0.330), while MG stiffness remained reduced (P < 0.05). Although CMJ height recovered at 24 h (P = 0.842), eccentric and braking phase durations remained prolonged (P < 0.001; ηp² = 0.357 and ηp² = 0.264), indicating altered neuromuscular strategies. For dynamic balance, a delayed impairment was observed in anterior reach distance, which declined only at 24 h compared to baseline (P = 0.021, ηp² = 0.133). Conclusion: Localized plantar flexion fatigue induces region-specific mechanical alterations and asynchronous recovery. Restoration of jump height at 24 h masks persistent deficits in eccentric phase durations and MG stiffness. These findings highlight a “neuromuscular vulnerability window” at 24 h post-fatigue, where delayed impairments in MG mechanics and anterior stability may increase potential susceptibility to injury despite apparent recovery. Practically, monitoring head-specific muscle mechanics, rather than global performance outcomes, is critical during this 24 h window to optimize training modification and guide objective return-to-play decisions. Trial registration: NCT07457398 (Registration date: February 25, 2026). © The Author(s) 2026.Öğe Effects of adjuvant propofol on antitumoral effects of carboplatin in experimental endometrial cancer: possible epigenetic associations(2026) Gürel, Çevik; Kuşçu, Gökçe Ceren; Buhur, Aylin; Dizakar, Saadet Özen Akarca; Kara, Hale Güler; Özateş, Neslihan Pınar; Yıldırım, Nuri; Günüşen, İlkbenEndometrial cancer (EC) is a gynecological malignancy classified into two biologically distinct subtypes, Type I and Type II EC. The more aggressive Type II EC exhibits a poor response to conventional platinum-based chemotherapy. Propofol, an anesthetic agent in gynecologic surgery, has been reported to exert antitumor effects beyond anesthesia; however, its role as a chemoadjuvant in EC remains insufficiently explored. In this study, we investigated the effects of propofol combined with carboplatin on drug resistance- and metastasis-associated microRNAs and genes using in vitro and in vivo Type II EC model. Propofol treatment significantly reduced cancer cell viability and migratory capacity, while the combination treatment showed greater antimetastatic effects compared with carboplatin alone. In xenograft models, combination therapy resulted in a significant reduction in tumor volume and suggested reduced metastatic involvement in lung and liver tissues. Molecular analyses revealed downregulation of oncogenic microRNAs (miR-21, miR-135a) and upregulation of tumor-suppressive microRNAs (miR-34b, miR-98), accompanied by reduced mTOR, c-Myc, MRP7, and N-cadherin expression and increased PTEN and HMGB1 levels. Collectively, these findings indicate that propofol is associated with greater antitumor effects when combined with carboplatin, accompanied by changes in miRNA-gene expression patterns.Öğe Stress distribution in titanium and zirconia implants with full-arch prostheses: a finite element analysis(2026) Saz, Bahattin; Özyılmaz, Özgün Yusuf; Özyılmaz, Özge DoğanayObjective: The stress distribution and mechanical properties of materials used in dental implants are critically important for implant success and long-term stability. The aim of this study was to evaluate the stress distribution on implant, prosthetic system, and peri-implant tissues when titanium and zirconia implants are used with different framework materials using three-dimensional finite element analysis (FEA). Methods: A three-dimensional edentulous maxilla model was reconstructed from computed tomography data, and twelve finite element models were subsequently developed based on this anatomy to represent different implant and framework configurations. Within the scope of the study, titanium and zirconia implants were modeled in combination with cantilevered and noncantilevered prosthesis types and Co-Cr, PEKK, and zirconium framework materials. An oblique static load of 200 N was applied at a 45° angle in the palato-buccal direction to the central fossa of the first molar on the models. The Von Mises and principal stress distributions in the implant, abutment, screw, framework, and peri-implant bone were examined. Results: The highest Von Mises value was recorded in the cantilevered PEKK framework zirconia implant model (378.388 MPa). Compared with the Co-Cr and zirconium framework, the PEKK framework resulted in higher Von Mises stresses and greater prosthesis displacement. The presence of a cantilever increased stress levels in all framework materials, and stress concentrations were observed particularly in posterior abutments and peri-implant bone. Furthermore, stress values in trabecular bone were recorded above the physiological threshold level in the cantilevered PEKK framework models. Conclusions: Although zirconia implants exhibited greater stress than titanium implants, they remained within safe limits. Rigid framework materials and cantilever-free designs provide more balanced biomechanical results.Öğe The Role of Boron in the Diet and as a Dietary Supplement(2026) Kuru Yaşar, Hülya; Yarat, AyşenBoron is a naturally occurring trace element that has historically received limited attention in human nutrition and is of increasing biological importance. It is widely found in nature, primarily through food and drinking water, and has attracted attention for its potential health benefits. Emerging evidence suggests that boron supplementation may support bone health, cognitive function, mineral and hormonal metabolism, the antioxidant defense system, body weight regulation, and inflammation reduction. This review examines the physiological roles, health, and clinical effects of boron, both through dietary intake and supplementation. Although not currently classified as an essential nutrient, boron appears to be biologically important, and it is thought that supplementation may have positive effects on many health conditions, including osteoporosis, osteoarthritis, body weight regulation, cancer prevention and treatment, diseases associated with oxidative stress, neurological and mental disorders, and hormonal imbalance.Öğe Spatial characterization of the phoenixin receptor in the lacrimal and major salivary glands(2026) Gürler, Esra Bihter; Elmas, M.A.; Eyüpoğlu, I.P.; Arbak, S.; Çevik Aras, H.Objective: To identify and characterize the expression of phoenixin receptor GPR173 (G protein-coupled receptor 173) in the rat lacrimal and major salivary glands (parotid, submandibular, and sublingual). GPR173 is associated with hormonal regulation and autoimmunity; however, its expression in exocrine glands has yet to be characterized. Design: Under anesthesia, eight Sprague Dawley rats underwent bilateral dissection of the lacrimal and major salivary glands. GPR173 expression was assessed using Western blotting and immunofluorescence. Immunoreactivity was quantified using ImageJ software and compared using the Friedman test with DunnBonferroni post hoc analysis. Results: GPR173 protein expression was found in all examined exocrine glands. In the major salivary glands, GPR173 was detected in both acinar and ductal cells, while expression was confined to acinar cells in the lacrimal gland. The submandibular and parotid glands showed significantly higher immunoreactivity than the lacrimal gland (p < .01 and p < .05, respectively). Ductal epithelium showed stronger immunopositivity compared to acinar epithelium. GPR173 immunoreactivity was also observed in periductal stromal tissue in major salivary glands. Conclusion: GPR173 expression was observed in both acinar and ductal cells of all major salivary glands, while in the lacrimal gland, it was restricted to the acinar cells. This differential localization suggests tissue-specific relevance.Öğe Assessment of Surface Roughness and Bacterial Adhesion of Occlusal Splints Fabricated with Different Layer Thicknesses, Polishing Techniques and Build Orientations(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Dede, Merve; Saygılı, Sina; Topçuoğlu, NursenThis study evaluated the combined effects of build orientation, layer thickness, and polishing protocols on surface roughness and bacterial adhesion of occlusal splints. Ten disc-shaped specimens (Ø16 × 3 mm) were fabricated for each group using a digital light processing (DLP)-based 3D printer. Specimens were printed at two orientations (0° and 90°) and two layer thicknesses (50 and 100 µm) using a splint resin. Surface roughness was measured with a contact profilometer, and bacterial adhesion was measured by optical density (OD) readouts for Streptococcus mutans using a spectrophotometer. Surface morphology was examined by field-emission scanning electron microscopy (SEM). Statistical analyses were performed using jamovi. Because normality and/or homogeneity assumptions were not met, robust analysis of variance was applied. Polishing protocol significantly affected surface roughness (Ra) values. Unpolished specimens showed the highest Ra values, whereas mechanical polishing combined with centrifugation produced the lowest values. No significant main effects of polishing protocol, layer thickness or orientation were observed for bacterial adhesion. SEM findings supported the roughness results. Surface roughness was primarily influenced by polishing protocols and their interactions, whereas bacterial adhesion remained relatively stable. The weak Ra–OD correlation indicated that surface roughness alone was not a reliable predictor of bacterial adhesion.Öğe Postoperative thirst in children: Experience of children's, parents and health professionals(2026) Şensoy, Özlem; Mert, Sabiha; Aydın, Ayfer; Şahin, CeylanThirst is one of the most distressing symptoms experienced by pediatric patients after surgery. This study aimed to explore and document the experiences of children, parents, and health professionals regarding postoperative thirst, providing insights to develop care strategies that address the emotional and psychological needs of pediatric patients. Design: A qualitative approach was employed to gather in-depth insights into the experiences of children, parents, and health professionals regarding postoperative thirst. Methods: Purposive sampling was employed in a Pediatric Surgery Unit, involving a total of 40 participants: ten children, sixteen parents, and fourteen health professionals. Semi-structured interviews were conducted with all participants, and the transcribed data were analyzed using qualitative content analysis. Findings: The content analysis revealed five themes: physical symptoms, feeling of discomfort, lack of knowledge, coping strategies, and suggestions. Conclusions: This qualitative study highlights the critical importance of addressing postoperative thirst in enhance the physical and emotional well-being of pediatric patients, emphasizing that thirst is not merely a physical symptom but a multidimensional experience that significantly affects children and their families. Implications to practice: This findings supports health professional should be educated on recognizing and managing postoperative thirst as a symptom in postoperative care. Integrating evidence-based thirst management strategies into postoperative care protocols can significantly improve patient outcomes, reduce anxiety, and promote recovery, ultimately advancing the quality of pediatric surgical care. © 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Öğe The Impact of Social Media Based Advice on Health Behaviors in Digital Health Communication(Journal of Health Communication, 2026) Öngel, Volkan; Yurttaş, Özge Uluğ; Ateş, Gözde Bozkurt; Gümüşboğa, Yağmur; Mutlu, HaticeThe growing visibility of social media influencers has increased interest in their role in shaping health beliefs and behaviors. While prior research has largely focused on message characteristics or direct behavioral outcomes, less attention has been given to the conditions under which influencer-based health messages are interpreted and translated into action. This study conceptualizes influencer-based health communication not as a direct persuasive force, but as a conditional communication process. Drawing on Uses and Gratifications Theory and the Health Belief Model as interpretive frameworks, it examines how individuals engage with health-related influencer content, how such engagement relates to health perceptions, and how digital health literacy shapes message interpretation.Survey data from social media users were analyzed using Firth's penalized logistic regression to address the rarity of influencer-driven health behavior. Findings indicate that, despite high levels of exposure to influencer-based health content, the translation of such exposure into health-related action remains limited. Exposure to health content significantly increases the likelihood of influencer-driven behavior, whereas higher digital health literacy reduces this likelihood, suggesting a protective effect. Additionally, perceived commercial intent decreases the probability that influencer recommendations lead to action.By distinguishing between engagement and behavioral change, this study reframes influencer effects as conditional outcomes shaped by motivations, perceptions, and interpretive competencies. It contributes to health communication literature by moving beyond linear persuasion models and highlighting the critical role of digital health literacy. The findings also offer practical implications for strengthening individuals' ability to critically evaluate health information in digital environments.Öğe Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model(2026) Gürel, Çevik; Tut, Ezgi; Kuşçu, Gökçe Ceren; Buhur, Aylin; Germiyan, Özgün Selim; Leila Sabour-Takanlou; Maryam Sabour-Takanlou; Güler, Cem; Yavaşoğlu, Nefise Ülkü Karabay; Oltulu, Fatih; Yavaşoğlu, AltuğParkinson's Disease (PD) is a prevalent neurodegenerative disorder. Recent studies implicate BRCA1-/BRCA2-containing complex 3 (BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study aimed to evaluate the therapeutic potential of BRCC3 silencing via systemically administered siRNA-loaded niosomes in a rotenone-induced rat model of PD. Niosomes were synthesised by thin-film hydration, and three BRCC3-targeted siRNA sequences were tested in primary midbrain dopaminergic neurons. The most effective sequence, identified by Real-Time Quantitative PCR (RT-qPCR) and immunofluorescence, was used for in vivo studies. The PD model was induced in adult male rats (n = 24/group) by subcutaneous rotenone administration (2 mg/kg/day) for 35 days. In the in vivo phase of the study, behavioural, biochemical, in vivo imaging (IVIS), histological, and RT-qPCR analyses were performed. IVIS analysis confirmed brain accumulation of niosome-siRNA complexes within 3-5 h. Complementary analyses demonstrated that siRNA treatment significantly enhanced locomotor performance, restored redox homeostasis and dopamine levels, attenuated neuronal loss, upregulated autophagy-related proteins (↑LC3-II, ↑Beclin), suppressed endoplasmic reticulum stress markers (↓GRP78/Bip, ↓CHOP), elevated tyrosine hydroxylase expression, and reduced α-synuclein accumulation. In conclusion, siRNA-mediated suppression of BRCC3 via siRNA-loaded niosomes provides neuroprotection by modulating autophagy, ER stress, and antioxidant pathways, supporting BRCC3 as a promising therapeutic target for PD.Öğe Disaster management in Türkiye: a qualitative study on healthcare professionals(2026) Mutlu, Hatice; Türkoğlu, Mesut Can; Erküvün, Kübra SezenBackground Disasters pose complex challenges that extend beyond immediate emergency response, requiring well-coordinated, resilient, and health-centered disaster management systems. In disaster-prone countries such as Türkiye, understanding how health services, particularly specialized medical rescue teams, function in real disaster settings is critical for identifying systemic gaps and improving preparedness, coordination, and response capacity. The aim of this study is to examine the managerial and organizational challenges encountered in disaster management processes based on the experiences of UMKE personnel who have served during various disasters in Türkiye, and to derive implications for strengthening disaster preparedness and response capacity. Methods The study was conducted using a qualitative research design. In-depth interviews were carried out with healthcare professionals who participated in disaster response. The data were analyzed using thematic analysis, and the findings were categorized into five main themes: shortages of logistics and equipment; working conditions and training; social awareness; lack of coordination, communication, and organization; and institutional structure and local empowerment. Results The findings revealed that road damages hindered transportation and that alternative transportation plans were inadequate. Disaster training were not fully adapted to field conditions. Public disaster literacy was found to be low. Insufficient coordination and communication disrupted interventions. In addition, the study identified psychosocial support, community-based education, and institutional capacity building as critical components of effective disaster management. Conclusions This study was designed to capture the personal perspectives of healthcare professionals who directly confronted disasters and gained first-hand experience of related processes. Therefore, it provides a unique contribution by presenting a disaster management framework through the lens of healthcare professionals and by highlighting areas in need of improvement for policymakers in this field.Öğe Comparison of color stability and wear resistance of different 3D printed definitive restorative resins(2026) Gündoğan, Zülal Çoban; Özyılmaz, Özgün Yılmaz; Kara, ÖzlemStatement of problem: Subtractive manufacturing in computer-aided design and computer-aided manufacturing (CAD-CAM) systems has been extensively studied, but additive manufacturing materials, particularly those used for definitive restorations, are relatively new and data regarding their clinical performance remain limited. Purpose: This in vitro study aimed to evaluate the color stability of 3 different 3-dimensionally (3D) printed definitive restorative materials under 5 different Commission Internationale de l'Eclairage illuminants and to compare their metameric color differences. In addition, the mechanical wear resistance of these materials was evaluated independently. Material and methods: A total of 135 specimens with thicknesses of 1.0, 1.5, and 2.0 mm were 3D printed according to the manufacturers' protocols. Color was evaluated before and after thermocycling under 5 illumination conditions (D65, D50, A, F11, F2). ΔE00 values were analyzed using mixed-design analysis of variance (α=.05). Wear was evaluated in 2.0-mm specimens using simulated mastication and volumetric analysis, and the wear data were analyzed using the Kruskal-Wallis test (α=.05) RESULTS: All specimens exposed to illuminant A exhibited clinically unacceptable color changes, regardless of material type or thickness. Under illuminants D50, F11, and F2, color changes were perceptible but remained within clinically acceptable limits. Thermal aging significantly reduced ΔE00 values (P=.001). Although wear was observed in all groups, no significant differences were found in volumetric loss (P=.139). Conclusions: Illuminants significantly influenced color stability across all resin types and thicknesses, whereas increased restoration thickness was associated with reduced color change perceptibility. In addition, no significant differences in wear volume were found among the tested 3D-printed definitive restorative materials.Öğe Endocrine and metabolism modulating effects of paracetamol: From in vitro signaling to in vivo metabolic reprogramming in male mice(Elsevier, 2026) Entezari, Bita; Bozdağ, Deniz; Buhur, Aylin; Sabuncuoğlu, Suna; Yavaşoğlu, Altuğ; Orhan, Hande GürerObesity is a major global health challenge associated with a cluster of comorbidities, including metabolic syndrome and type 2 diabetes, necessitating a deeper understanding of the environmental factors contributing to this epidemic. This study investigated the in vitro adipogenic/lipogenic potential of paracetamol and its in vivo endocrine and metabolic modulating effects following prenatal exposure. Using the 3T3-L1 preadipocyte model, cells were exposed to paracetamol at physiologically relevant concentrations. Results demonstrated that paracetamol promoted lipid accumulation and upregulated G3PDH activity. Furthermore, low concentrations significantly increased the protein expression of key adipogenic regulators (PPARγ, C/EBPα, LPL, and SREBP1), suggesting interference with transcriptional cascades governing adipogenesis and lipogenesis. To assess in vivo effects, pregnant CD1 mice were exposed to paracetamol at three human relevant doses (Cmax/10, Cmax, and Cmax×10). In male F1 offspring, prenatal exposure resulted in increased anogenital distance and a higher incidence of sperm morphological abnormalities, indicating reproductive developmental alterations despite unchanged circulating hormone levels. Metabolically, offspring exhibited dyslipidemia characterized by elevated serum triglycerides and total cholesterol. Although body weight and glucose tolerance remained unaffected, lipidomic profiling of epididymal adipose tissue revealed pronounced remodeling, including the accumulation of neutral lipids and altered membrane phospholipid composition. This was accompanied by the upregulation of the adipogenic genes Pparγ, Lpl, and Fasn in adipose tissue. Collectively, these findings suggest that paracetamol may act as an endocrine modulator and metabolic disruptor when exposed prenatally, inducing latent metabolic dysregulation that may predispose offspring to metabolic syndrome later in life, even in the absence of overt obesityÖğe Comparison of tensile bond strengths of different impression materials used with custom trays fabricated by 3D printing(2026) Topalan, Onur; Özyılmaz, Özgün YusufBackground: This study aimed to evaluate and compare the tensile bond strength between four different impression materials and custom trays fabricated using various photopolymer-based threedimensional (3D) printing materials and one conventional method. Additionally, the effect of three surface treatments on bond strength was investigated. Methods: A total of 288 custom tray specimens were fabricated using four different techniques: Stereolithography (SLA), liquid crystal display (LCD), digital light processing (DLP), and a conventional light-cured urethane dimethacrylate (UDMA)-based acrylic. Each tray type was subjected to three surface treatments: adhesive-only, perforated-only, and perforated + adhesive. Four elastomeric impression materials were tested: polyvinylsiloxane, condensation silicone, polyether, and vinylsiloxanether. A standardized CAD model was used for all trays. The impression materials were applied onto the tray surfaces, and tensile bond strength was tested using a universal testing machine. Each condition was tested with six replicates (n = 6). Data were recorded in Newtons and converted to megapascal (MPa) using a standardized bonding surface area of 825 mm². Three-way ANOVA and Tukey’s post-hoc tests were conducted (α=0.05). Results: All three independent variables - printing technique, surface treatment, and impression material - had a statistically significant effect on tensile bond strength (p < 0.001). The highest mean bond strength (0.272 MPa) was observed with the DLP-printed tray using perforatedonly and polyether impression material. The lowest value (0.018 MPa) was found with the same tray type and surface treatment, but with condensation silicone. Among surface treatments, adhesive-only and adhesive + perforated trays showed significantly higher bond strengths compared to perforated-only groups (p = 0.001). Polyether showed significantly higher bond strength than all other impression materials, while condensation silicone yielded the lowest. Conclusions: Within the limitations of this in vitro study, tray fabrication method and surface treatment significantly influenced bonding with impression materials. The present findings may provide useful preliminary data for future clinical investigations evaluating retention characteristics of 3D-printed custom trays.Öğe Volumetric Three-Dimensional Evaluation of the Pharyngeal Airway After Orthognathic Surgery in Patients with Skeletal Class III Malocclusion(MDPI, 2025) Öz, Aslıhan Zeynep; El, Hakan; Öz, Abdullah Alper; Palemo, Juan MartinBackground: Orthognathic surgery significantly alters the dimensions of the pharyngeal airway. This study’s objective was to assess alterations in the pharyngeal airway volume via cone-beam computed tomography (CBCT) after orthognathic surgery in patients with skeletal Class III malocclusion. Methods: This retrospective study analyzed CBCT images from 23 patients with skeletal Class III malocclusion (13 females, 10 males), who were categorized into two groups based on the surgical approach: double-jaw and single-jaw surgery. The double-jaw group included 13 patients who underwent bilateral sagittal split osteotomy (BSSO) and Le Fort I osteotomy, whereas the single-jaw group included of 10 patients who had underwent BSSO only. CBCT images were evaluated both before surgery and at a minimum of three months after surgery. The oropharyngeal volume (OP), nasopharyngeal volume (NP), total airway volume, posterior airway space (PAS), and the most constricted area at the base of the tongue (minAx) were measured. Statistical analyses were performed using either paired t-tests or Wilcoxon signed-rank tests depending on data normality, with a significance level set at p < 0.01. Results: In the double-jaw group, a significant volumetric increase was observed in the nasopharynx (5316 ± 1948 mm3 to 6064 ± 1899 mm3 ; p = 0.010) and oropharyngeal volume decreased from 17,097 ± 5675 mm3 to 14,290 ± 5835 mm3 ; however, this reduction was not statistically significant (p = 0.017). In contrast, the single-jaw group showed a significant reduction in oropharyngeal volume from 15,620 ± 5040 mm3 to 12,444 ± 4701 mm3 (p = 0.010), with no significant change in nasopharyngeal volume (p = 0.551). Total airway volume significantly decreased only in the single-jaw group (from 20,452 ± 7754 mm3 to 16,846 ± 6529 mm3 , p = 0.010). Additionally, both groups exhibited marked decreases in PAS and minimum axial area values (all p < 0.01). Conclusions: Orthognathic surgery led to a significant volumetric increase in the nasopharynx in the double-jaw group, whereas the oropharynx volume significantly decreased only in the single-jaw group. Additionally, both surgical approaches resulted in a marked reduction in PAS and minimum axial area values, highlighting a notable impact on posterior airway dimensions.Öğe Color matching and metameric behavior of composite resins applied on anodized titanium surfaces: an in vitro spectrophotometric study(2026) Davut, Umur; Özyılmaz, Özge Doğanay; Özyılmaz, Özgün YusufBackground The aim of this study was to evaluate the color matching and metameric behavior of two different composite resins applied to titanium surfaces anodized to yellow and pink colors. The study aimed to determine the effects of anodization color and composite resin type on color performance in hybrid prosthesis and screw access hole closure applications. Materials and methods A total of 72 Grade 5 titanium discs (10 mm diameter × 2 mm thickness) were allocated to three anodization conditions: nonanodized/gray (0 V, n = 24), yellow (55 V, n = 24), and pink (80 V, n = 24). Each anodization group was subdivided into two subgroups: 3 M Filtek Z250 (microhybrid) and Tokuyama Estelite Sigma Quick (supra-nano hybrid) composite resins (A2 shade, 2 mm thickness; n = 12 per subgroup). Gray titanium + composite specimens were used as the reference for ΔE₀₀ calculations; yellow and pink anodization groups constituted the experimental groups. Color measurements were performed using a spectrophotometer (Konica Minolta CM-3700 A) under four light sources (D65, D50, incandescent A, and F11). Data were analyzed using mixed-design repeated-measures ANOVA, Bonferroni post hoc test, and independent samples t-test (α = 0.05). Results Anodization color (η² = 0.941) and composite type (η² = 0.952) demonstrated strong effects on ΔE₀₀ values (both p < 0.001). Light source showed statistically significant but clinically negligible effect (η² = 0.521, mean difference < 0.1 ΔE₀₀). Pink anodization exhibited higher color differences than yellow (2.84–2.99 vs. 1.53–1.62), and Tokuyama composite higher than 3 M (2.89–3.12 vs. 1.41–1.54) (both p < 0.001). Yellow+3 M combination showed lowest values (0.91–0.97), while Pink+Tokuyama showed highest (3.68–3.97). Metamerism index remained minimal (MI < 0.21). Conclusions Careful material selection is essential for optimal esthetics in anodized titanium-composite systems. Yellow anodization combined with a microhybrid composite demonstrated the most favorable color matching performance under
