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Öğe Endocrine and metabolism modulating effects of paracetamol: From in vitro signaling to in vivo metabolic reprogramming in male mice(Elsevier, 2026) Entezari, Bita; Bozdağ, Deniz; Buhur, Aylin; Sabuncuoğlu, Suna; Yavaşoğlu, Altuğ; Orhan, Hande GürerObesity is a major global health challenge associated with a cluster of comorbidities, including metabolic syndrome and type 2 diabetes, necessitating a deeper understanding of the environmental factors contributing to this epidemic. This study investigated the in vitro adipogenic/lipogenic potential of paracetamol and its in vivo endocrine and metabolic modulating effects following prenatal exposure. Using the 3T3-L1 preadipocyte model, cells were exposed to paracetamol at physiologically relevant concentrations. Results demonstrated that paracetamol promoted lipid accumulation and upregulated G3PDH activity. Furthermore, low concentrations significantly increased the protein expression of key adipogenic regulators (PPARγ, C/EBPα, LPL, and SREBP1), suggesting interference with transcriptional cascades governing adipogenesis and lipogenesis. To assess in vivo effects, pregnant CD1 mice were exposed to paracetamol at three human relevant doses (Cmax/10, Cmax, and Cmax×10). In male F1 offspring, prenatal exposure resulted in increased anogenital distance and a higher incidence of sperm morphological abnormalities, indicating reproductive developmental alterations despite unchanged circulating hormone levels. Metabolically, offspring exhibited dyslipidemia characterized by elevated serum triglycerides and total cholesterol. Although body weight and glucose tolerance remained unaffected, lipidomic profiling of epididymal adipose tissue revealed pronounced remodeling, including the accumulation of neutral lipids and altered membrane phospholipid composition. This was accompanied by the upregulation of the adipogenic genes Pparγ, Lpl, and Fasn in adipose tissue. Collectively, these findings suggest that paracetamol may act as an endocrine modulator and metabolic disruptor when exposed prenatally, inducing latent metabolic dysregulation that may predispose offspring to metabolic syndrome later in life, even in the absence of overt obesityÖğe Comparison of tensile bond strengths of different impression materials used with custom trays fabricated by 3D printing(2026) Topalan, Onur; Özyılmaz, Özgün YusufBackground: This study aimed to evaluate and compare the tensile bond strength between four different impression materials and custom trays fabricated using various photopolymer-based threedimensional (3D) printing materials and one conventional method. Additionally, the effect of three surface treatments on bond strength was investigated. Methods: A total of 288 custom tray specimens were fabricated using four different techniques: Stereolithography (SLA), liquid crystal display (LCD), digital light processing (DLP), and a conventional light-cured urethane dimethacrylate (UDMA)-based acrylic. Each tray type was subjected to three surface treatments: adhesive-only, perforated-only, and perforated + adhesive. Four elastomeric impression materials were tested: polyvinylsiloxane, condensation silicone, polyether, and vinylsiloxanether. A standardized CAD model was used for all trays. The impression materials were applied onto the tray surfaces, and tensile bond strength was tested using a universal testing machine. Each condition was tested with six replicates (n = 6). Data were recorded in Newtons and converted to megapascal (MPa) using a standardized bonding surface area of 825 mm². Three-way ANOVA and Tukey’s post-hoc tests were conducted (α=0.05). Results: All three independent variables - printing technique, surface treatment, and impression material - had a statistically significant effect on tensile bond strength (p < 0.001). The highest mean bond strength (0.272 MPa) was observed with the DLP-printed tray using perforatedonly and polyether impression material. The lowest value (0.018 MPa) was found with the same tray type and surface treatment, but with condensation silicone. Among surface treatments, adhesive-only and adhesive + perforated trays showed significantly higher bond strengths compared to perforated-only groups (p = 0.001). Polyether showed significantly higher bond strength than all other impression materials, while condensation silicone yielded the lowest. Conclusions: Within the limitations of this in vitro study, tray fabrication method and surface treatment significantly influenced bonding with impression materials. The present findings may provide useful preliminary data for future clinical investigations evaluating retention characteristics of 3D-printed custom trays.Öğe Volumetric Three-Dimensional Evaluation of the Pharyngeal Airway After Orthognathic Surgery in Patients with Skeletal Class III Malocclusion(MDPI, 2025) Öz, Aslıhan Zeynep; El, Hakan; Öz, Abdullah Alper; Palemo, Juan MartinBackground: Orthognathic surgery significantly alters the dimensions of the pharyngeal airway. This study’s objective was to assess alterations in the pharyngeal airway volume via cone-beam computed tomography (CBCT) after orthognathic surgery in patients with skeletal Class III malocclusion. Methods: This retrospective study analyzed CBCT images from 23 patients with skeletal Class III malocclusion (13 females, 10 males), who were categorized into two groups based on the surgical approach: double-jaw and single-jaw surgery. The double-jaw group included 13 patients who underwent bilateral sagittal split osteotomy (BSSO) and Le Fort I osteotomy, whereas the single-jaw group included of 10 patients who had underwent BSSO only. CBCT images were evaluated both before surgery and at a minimum of three months after surgery. The oropharyngeal volume (OP), nasopharyngeal volume (NP), total airway volume, posterior airway space (PAS), and the most constricted area at the base of the tongue (minAx) were measured. Statistical analyses were performed using either paired t-tests or Wilcoxon signed-rank tests depending on data normality, with a significance level set at p < 0.01. Results: In the double-jaw group, a significant volumetric increase was observed in the nasopharynx (5316 ± 1948 mm3 to 6064 ± 1899 mm3 ; p = 0.010) and oropharyngeal volume decreased from 17,097 ± 5675 mm3 to 14,290 ± 5835 mm3 ; however, this reduction was not statistically significant (p = 0.017). In contrast, the single-jaw group showed a significant reduction in oropharyngeal volume from 15,620 ± 5040 mm3 to 12,444 ± 4701 mm3 (p = 0.010), with no significant change in nasopharyngeal volume (p = 0.551). Total airway volume significantly decreased only in the single-jaw group (from 20,452 ± 7754 mm3 to 16,846 ± 6529 mm3 , p = 0.010). Additionally, both groups exhibited marked decreases in PAS and minimum axial area values (all p < 0.01). Conclusions: Orthognathic surgery led to a significant volumetric increase in the nasopharynx in the double-jaw group, whereas the oropharynx volume significantly decreased only in the single-jaw group. Additionally, both surgical approaches resulted in a marked reduction in PAS and minimum axial area values, highlighting a notable impact on posterior airway dimensions.Öğe Color matching and metameric behavior of composite resins applied on anodized titanium surfaces: an in vitro spectrophotometric study(2026) Davut, Umur; Özyılmaz, Özge Doğanay; Özyılmaz, Özgün YusufBackground The aim of this study was to evaluate the color matching and metameric behavior of two different composite resins applied to titanium surfaces anodized to yellow and pink colors. The study aimed to determine the effects of anodization color and composite resin type on color performance in hybrid prosthesis and screw access hole closure applications. Materials and methods A total of 72 Grade 5 titanium discs (10 mm diameter × 2 mm thickness) were allocated to three anodization conditions: nonanodized/gray (0 V, n = 24), yellow (55 V, n = 24), and pink (80 V, n = 24). Each anodization group was subdivided into two subgroups: 3 M Filtek Z250 (microhybrid) and Tokuyama Estelite Sigma Quick (supra-nano hybrid) composite resins (A2 shade, 2 mm thickness; n = 12 per subgroup). Gray titanium + composite specimens were used as the reference for ΔE₀₀ calculations; yellow and pink anodization groups constituted the experimental groups. Color measurements were performed using a spectrophotometer (Konica Minolta CM-3700 A) under four light sources (D65, D50, incandescent A, and F11). Data were analyzed using mixed-design repeated-measures ANOVA, Bonferroni post hoc test, and independent samples t-test (α = 0.05). Results Anodization color (η² = 0.941) and composite type (η² = 0.952) demonstrated strong effects on ΔE₀₀ values (both p < 0.001). Light source showed statistically significant but clinically negligible effect (η² = 0.521, mean difference < 0.1 ΔE₀₀). Pink anodization exhibited higher color differences than yellow (2.84–2.99 vs. 1.53–1.62), and Tokuyama composite higher than 3 M (2.89–3.12 vs. 1.41–1.54) (both p < 0.001). Yellow+3 M combination showed lowest values (0.91–0.97), while Pink+Tokuyama showed highest (3.68–3.97). Metamerism index remained minimal (MI < 0.21). Conclusions Careful material selection is essential for optimal esthetics in anodized titanium-composite systems. Yellow anodization combined with a microhybrid composite demonstrated the most favorable color matching performance underÖğe Does knee joint proprioception differ according to age and gender in healthy adults?(2026) Kürklü, Galip Bilen; Yapalı, Gökmen; Arslan, Serdar; Çankaya, MusaBackground: This study aimed to investigate the effects of age and gender on knee joint position sense (KJPS) and movement sense (KJMS) in healthy adults. Methods: General physical activity was evaluated using the International Physical Activity Questionnaire-Short Form (IPAQ-Sf) and the Tegner Activity Scale (TAS). Knee discomfort was measured with the Lysholm Knee Score (LKS), and knee-related symptoms and functional status were assessed using the Knee Osteoarthritis Outcome Score (KOOS). Knee joint position sense (KJPS) was tested at 15°, 30°, 45°, and 60°, while knee joint movement sense (KJMS) was evaluated at 60° and 90°. Participants were categorized by gender (male, female) and age (18-29, 30-44, ≥ 45 years). Mixed-effects models were applied to analyze numerical data, and post hoc comparisons were conducted using least-squares means with Tukey's correction when appropriate. Results: The mean scores were KOOS = 96.41 ± 4.79, LKS = 96.41 ± 6.94, and IPAQ-Sf = 1772.02 ± 1332.10. Absolute errors for KJPS angles ranged from 2.58 to 3.42 between genders. KJMS at 60°-90° was measured between 1.82 and 1.95 s in males, and between 1.66 and 1.80 s in females. Significant differences in KJMS (60°-90°) were observed across age groups (F = 14.841, p < 0.001) and position-sense angles (F = 19.645, p < 0.001). Conclusion: KJPS assessment revealed significant differences in absolute errors by age and gender. Males demonstrated lower errors, while participants aged ≥ 45 years exhibited greater deviations than younger groups. No gender differences were identified in KJMS. Overall, proprioception declined significantly in the 45+ age group.Öğe Mitochondrial Dynamics‑Related Gene Regulation by Epigenetic Suppression of GCN5 Exerts Neuroprotective Effects in Rotenone‑Induced Parkinson’s Disease Model(2026) Kuşçu, Gökçe Ceren; Tut, Ezgi; Gürel, Çevik; Buhur, Aylin; Germiyan, Özgün Selim; Avcı, Çığır Biray; Güler, Cem; Şancı, Ebru; Yavaşoğlu, Nefise Ülkü Karabay; Yavaşoğlu, AltuğParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and mitochondrial dysfunction. Recent studies implicate the histone acetyltransferase GCN5 in regulating mitochondrial homeostasis and oxidative stress. This study investigated the therapeutic potential of GCN5 silencing via systemically administered siRNA-loaded niosomes in a rotenone-induced rat model of PD. Niosomes were prepared using the thin-film hydration method, and the most effective siRNA sequence was selected through real time quantitative PCR (RT-qPCR) and immunofluorescence in primary mesencephalic neurons. Adult male rats were divided into four groups (n=24/group), and PD was induced with rotenone (2 mg/kg/day, s.c., for 35 days). Behavioral assessments, biochemical analyses, IVIS imaging, histopathology, immunohistochemistry, and RT-qPCR were conducted. IVIS confirmed brain accumulation of siRNA– niosomes within 3–5 h post-injection. GCN5 siRNA treatment significantly improved locomotor activity (p<0.05), decreased MDA levels (p<0.05), and restored SOD and dopamine levels (p<0.05). Molecular findings showed decreased GCN5 and mitochondrial fission-related gene Drp-1 expression, increased expression of mitophagy and biogenesis markers (↑Parkin, ↑PINK1, ↑Mfn2, ↑PGC-1α), elevated TH expression, and reduced α-synuclein accumulation. Histological analysis revealed preserved midbrain cytoarchitecture and reduced neuronal damage. In conclusion, these findings highlight that epigenetic silencing of GCN5 via siRNA-loaded niosomal delivery provides neuroprotection in PD by modulating the expression of genes involved in mitochondrial dynamics, offering preclinical support for its development as a novel therapeutic strategy.Öğe The relationship of the nutritional literacy level of individuals with diabetes on nutrition, quality of life, and metabolic control(2025) Seçkiner, Selda; Palamutoğlu, Merve İnce; Baş, Dilşat; İdiz, Cemile; Baş, MuratBackground Nutritional literacy is essential to improve the quality of life and metabolic control of individuals with diabetes. The aim is to evaluate the relationship between the Nutrition Literacy Level of Diabetic Individuals on Nutrition, Quality of Life, and Metabolic Control. Methods This study evaluated the relationship between the nutritional literacy level of 179 individuals diagnosed with diabetes aged 18-65 years with nutrition, quality of life, and metabolic control. The data of the study were obtained through a 5-part faceto-face survey method. Self-Perceived Food Literacy Scale (SPFLS) was used to measure the nutritional literacy of the participants, and the Quality-of-Life Short Form 36 (SF-36) was used to assess the health-related quality of life. Results Of the participants, 55.3% (n=99) had type-2 diabetes, and 44.7% (n=80) had type-1 diabetes. Their mean BMI was 27.83 ± 6.38 kg/m2 and an HbA1c value of 7.88 ± 2.13%. The mean age of individuals with type-1 diabetes participating in the study was 36.69±13.77, and those with type-2 diabetes as 55.60±9.91. In addition, when evaluated in terms of diabetes duration, the mean age was 13.17±9.74 years in those with type-1 diabetes and 11.80±8.13 years in those with type-2 diabetes. A statistically significant difference (p<0.05; p<0.001) was found in the SPFLS subfactor scores for ‘Social and Conscious Eating’ and ‘Food Label Analysis’ among diabetic individuals based on their diabetes type. However, no statistically significant difference was found in the SF-36 sub-factor scores (p>0.05). The study found a weak negative correlation between the BMI of individuals with type 1 diabetes and the SPFLS sub-factors ‘Resilience and Resistance’ and ‘Examining Food Labels’(p<0.05). In type-2 diabetics, BMI showed a weak positive correlation with ‘Food Preparation Skills’ and a weak negative correlation with ‘Resilience and Resistance,’ ‘Examining Food Labels,’ and ‘Physical Function’ (p<0.05). Additionally, in type-2 diabetics, BMI was weakly positively correlated with ‘Healthy Food Stockpiling,’ while the SF-36 sub-factors ‘Physical Function,’ ‘Role Physical,’ and ‘Vitality’ showed weak negative correlations” (p<0.05). While no significant statistical difference was found between the SPFLS sub-factors and HbA1c values in type-1 diabetic individuals (p>0.05), only the "Healthy Food Availability" sub-factor and HbA1c were found to be statistically significant in type-2 diabetic individuals (p<0.05).The subscales of SPFLS and SF-36 show significant relationships with the physical activity level, nutritional habits, body functions, mental health, social life, and general quality of life of individuals with ACCEPTED MANUSCRIPT ARTICLE IN PRESS ARTICLE IN PRESS diabetes, comprehensively revealing the disease's physical, psychosocial, and lifestyle effects on the individual. These findings support the significant associations of BMI and HbA1c with various lifestyle and health factors. Conclusions This study found that in type-1 diabetics, age and diabetes duration were positively correlated with food literacy and quality of life, while no such correlations were found in type-2 diabetics. Increasing food literacy in diabetes management may be an important component that can positively influence metabolic control, improve physical and mental health, and give individuals the option to manage their health and improve quality of life and well-being.Öğe Accuracy of Polyvinyl Siloxane Ether and Other Impression Materials in Full-Arch Implant Rehabilitation with Varying Angulations: A Comparative in Vitro Study(2025) Çapuroğlu, Akanay; Kayahan, Zeynep Özkurt; Kazazoğlu, EnderThis study evaluated the accuracy of digital and conventional impressions using different materials in fully edentulous jaws with implants at varying angulations. Two master models were fabricated: one with four parallel and another with four implants placed according to the all-on-4 protocol. Impressions were obtained using three materials—polyvinyl siloxane (PVS), polyether (PE), and polyvinyl siloxane ether (PVSE)—and a digital scanner (TRIOS 4). Conventional impressions were cast, scanned with an extraoral scanner, and compared with the reference models via Geomagic Control X software. In the parallel model, digital impressions exhibited significantly greater deviation values than PE (p=0.016). In the angulated model, PE demonstrated significantly lower deviation values compared to PVSE (p=0.007) and digital impressions (p=0.016). Deviation values increased with implant angulation in all groups, except PVSE, which showed no statistically significant difference. Polyether provided the highest accuracy. Implant angulation adversely affected accuracy across most impression methodsÖğe An Investigation of Sleep Quality, Stress, and Healthy Eating Status Among Shift-Working Firefighters: A Descriptive Cross Sectional Study(2025) Schoinas, Ezgi Sakar; Anık, Sema; Erkul, CahitThe aim of this study was to assess perceived stress, sleep quality, and healthy eating attitudes among fire department personnel and to examine the relationships among these variables, working in various units of the department daily. Methods: This descriptive cross-sectional study included 188 participants. Data were collected using a sociodemographic form, the Bergen Shift Work Sleep Questionnaire, the Perceived Stress Scale (Short Form), and the Attitude Scale for Healthy Nutrition (ASHN). Results: The ASHN total score was 75.84 ± 10.03, indicating generally positive nutrition attitudes. The Bergen score was 62.94 ± 19.15, reflecting moderate sleep disturbance. The Perceived Stress Scale score was 11.50 ± 2.61, showing moderate stress. Weak negative correlations were found between ASHN and the other scales, while Bergen and stress scores were positively correlated. Conclusions: Overall, shift-based, stressful firefighting work negatively affected sleep and stress.Öğe Predictive Value of Complete Blood Count Parameters for Alzheimer's Disease in Relation to Periodontal Status(Bentham Science, 2025) Karaduran, Kübra; Aydoğdu, Ahmet; Gelisin. Özlem; Günpınar, SadiyeGiven the role of inflammation in the development of both Alzheimer's disease (AD) and periodontal disease, it is plausible that periodontal disease may influence the progression of AD. Complete blood count (CBC) parameters may also serve as predictive indicators for this condition. This study investigated the predictive value of CBC parameters on the progression of AD in patients with periodontal disease.Öğe Deep Learning in neuroimaging for neurodegenerative diseases: State-of-the art, Challenges, and Opportunities(Elsevier B.V., 2025) Akan, Taymaz; Alp, Sait; Ledbetter, Christina Raye; Tafti, Ahmad P.; Arevalo, Octavio; Bhuiyan, Mohammad Alfrad NobelNeuroimaging is commonly used to diagnose neurodegenerative diseases (NDDs), providing crucial insights into brain changes before clinical symptoms manifest. Deep learning (DL) for neuroimaging can improve early diagnosis and disease monitoring. Clinical implementation of DL faces challenges in accurately representing realworld data. Recent models, particularly those focused on diagnostic categorization, have achieved high accuracy, but their applicability to patients is limited. Conflicting inferences have been reported, with findings from small cohorts generalizing conclusions without considering inter-scanner, intra- and inter-site variations. A theoretically feasible method involves gathering a comprehensive dataset that encompasses all patient demographics, but this presents practical challenges including harmonization, data incompleteness, class imbalance, and substantial costs. Existing research has also mostly focused on common NDDs like Alzheimer's Disease (AD) and Parkinson's Disease (PD). This contribution expands the literature by looking at a wider range of NDDs, exploring the latest advancements in applying deep learning algorithms to neuroimaging analysis for the diagnosis and monitoring of NDDs, including AD, Frontotemporal Dementia (FTD), Lewy Body Dementia, PD, Huntington's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. We emphasize how these approaches are handling spatial/temporal information available in brain volume imaging data. We conclude by discussing the challenges associated with the use of voxel-based, patch-based, ROI-based, and slice-based approaches in brain volume imaging. These challenges are further compounded by issues such as inter-site and inter-scanner variability, class imbalances in medical datasets, and the scarcity of accurately annotated data, all of which impact the performance and generalizability of deep learning models.Öğe Machine learning–assisted classification of lung cancer: the role of sarcopenia, inflammatory biomarkers, and PET/CT anatomical-metabolic parameters(Springer Science and Business Media Deutschland GmbH, 2025) Tanyildizi-Kokkulunk, Handan; Alcin, Goksel; Cavdar, Iffet; Akyel, Resit; Ciftci-Kusbeci, Tuba; Caliskan, GonulAccurate differentiation between non-cancerous, benign, and malignant lung cancer remains a diagnostic challenge due to overlapping clinical and imaging characteristics. This study proposes a multimodal machine learning (ML) framework integrating positron emission tomography/computed tomography (PET/CT) anatomic-metabolic parameters, sarcopenia markers, and inflammatory biomarkers to enhance classification performance in lung cancer. A retrospective dataset of 222 patients was analyzed, including demographic variables, functional and morphometric sarcopenia indices, hematological inflammation markers, and PET/CT derived parameters such as maximum and mean standardized uptake value (SUVmax, SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG). Five ML algorithms—Logistic Regression, Multi-Layer Perceptron, Support Vector Machine, Extreme Gradient Boosting, and Random Forest—were evaluated using standardized performance metrics. Synthetic Minority Oversampling Technique was applied to balance class distributions. Feature importance analysis was conducted using the optimal model, and classification was repeated using the top 15 features. Among the models, Random Forest demonstrated superior predictive performance with a test accuracy of 96%, precision, recall, and F1-score of 0.96, and an average AUC of 0.99. Feature importance analysis revealed SUVmax, SUVmean, total lesion glycolysis, and skeletal muscle index as leading predictors. A secondary classification using only the top 15 features yielded even higher test accuracy (97%). These findings underscore the potential of integrating metabolic imaging, physical function, and biochemical inflammation markers in a non-invasive ML-based diagnostic pipeline. The proposed framework demonstrates high accuracy and generalizability and may serve as an effective clinical decision support tool in early lung cancer diagnosis and risk stratification.Öğe Salvia argentea L. extract inhibits the production of NO, and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), alleviates the inflammatory response of LPS-induced macrophages cells, and reduces the CRP level on carrageenan-induced paw edema(Springer Science and Business Media Deutschland GmbH, 2025) Alhamedi, Almonther; Demiroz Akbulut, Tugce; Baykan, Sura; Gümüştaş, Barış; Sanci, Ebru; Alsakini, Karrar Ali Mohammed Hasan; Nalbantsoy, Ayşe; Yavasoğlu, Altuğ; Karabay Yavasoğlu, N. ÜlküSalvia argentea L. (Lamiaceae) is a medicinal plant originating from the Mediterranean region and has been used since ancient times for the treatment of various diseases. This study aimed to determine the phytochemical composition of S. argentea L. ethanol extract and to evaluate its in vitro and in vivo anti-inflammatory activity and its acute oral toxicity. The chemical constituents of the ethanol extract prepared from the aerial parts of the plant were identified using HPLC. The in vitro anti-inflammatory activity of the extract was evaluated in LPS-stimulated murine macrophage RAW 264.7 cells and the human monocytic cell line THP-1 by measuring the levels of nitric oxide (NO), pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Acute toxicity of the extract was assessed in accordance with OECD guideline no 423. In vivo anti-inflammatory activity was evaluated based on the inhibition of 1% carrageenan-induced paw edema in rats. Serum CRP levels as an inflammatory marker, were measured via ELISA. Histological and immunohistochemical assessments were performed to identify tissue changes in the paw. HPLC profiling revealed that the extract contained rosmarinic acid (11.334 µg/mg dry extract), and salvigenin (2.74 µg/mg of dry extract) as major compounds. The extract significantly inhibited the production of NO, IL-1β, IL-6, and TNF-α without affecting cell viability. In vivo, the extract treatment exhibited a dose-dependent reduction in paw edema and serum CRP levels, along with notable histological improvements. Administration of the extract resulted in dose-dependent decreases of NF-κB expressions in the paw tissues. No signs of acute toxicity were observed (oral LD₅₀ > 2000 mg/kg). These findings suggest that S. argentea L. ethanol extract possesses significant anti-inflammatory potential supporting its possible development as a natural therapeutic agent for inflammatory disorders.Öğe The Effect of Osteopathic Manipulative Treatment Adjunct on Stabilization Splint Treatment in Temporomandibular Joint Anterior Disc Displacement with Reduction Disorder: A Quantitative Analysis, Pilot Study(MDPI, 2025) Aklar, Ayca; Bal, Burcu; Tasdelen, Neslihan; Ertas, GokhanObjective: This study aimed to quantitatively assess the efficacy of osteopathic manipulative treatment (OMT) as an adjunct to stabilization splint treatment for temporomandibular joint anterior disc displacement with reduction (ADDwR) disorder. Method: Thirty-eight joints were evaluated in this study. OMT, in addition to splint treatment, was administered to the study group, and the control group only received splint treatment. Before and after the treatments, the quality of life, the pain levels of distinct body regions, and the sleep quality were evaluated, while mandibular movements were assessed and condyle–disc position differences measured on magnetic resonance images. Results: In all the life qualities, except social functionality, increases after treatment were present for both control and study groups, but the increase was significant in bodily pain for the control group (p = 0.034) while increases were significant in physical functionality (p = 0.018), general health perception (p = 0.027), and reported health transition (p = 0.019) for the study group. Significant pain reduction in all body regions was seen in the study groups (p = 0.007–0.033), but the decrease was only significant for the temporomandibular joint for the control group (p = 0.011). The sleep quality significantly improved for the study group (p = 0.018). Limited after-treatment improvements in the condyle–disc positions were determined for both the normal joints and joints with ADDwR in the study group. Conclusions: The application of OMT adjunct to splint treatment increases quality of life and sleep, reduces bodily pain, and improves condyle–disc positions over the MRIs of TMJ.Öğe Does inspiratory muscle training affect expiratory muscle thickness in respiratory intensive care patients? A pilot randomized controlled study(W B SAUNDERS CO-ELSEVIER INC, 2025) Benli, Reyhan Kaygusuz; Yilmaz, Baris; Yurdalan, S. UfukBackground: This randomized controlled trial aimed to compare abdominal muscle thickness between intensive care patients and healthy controls, and to evaluate the impact of IMT on expiratory muscle thickness using ultrasound. Methods: In this single-blind randomized controlled trial, 20 post-extubation intensive care patients were randomly assigned to either an a conventional physiotherapy (CP) group or IMT + CP group. Both interventions were applied for five days. An additional 10 healthy individuals served as controls for comparison. Abdominal muscle thicknesses-including external oblique (EOA), internal oblique (IOA), transversus abdominis (TRA), and rectus abdominis (RA)-were measured using ultrasound. Maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) were also recorded. Results: At baseline, healthy controls had significantly higher MIP, MIP% predicted, MEP, MEP% predicted, and RA muscle thickness compared to both patient groups (p < 0.05). Following intervention, both IMT and CP groups showed significant improvements in MIP (p < 0.05), but only the IMT group demonstrated significant increases in MEP, MEP% predicted, IOA, and RA muscle thickness (p < 0.05). The IMT group showed significantly greater improvements in MIP, MEP, IOA, and RA muscle thickness compared to the CP group (p < 0.05). Conclusion: Post-extubation IMT may improve not only inspiratory but also expiratory muscle strength and abdominal wall thickness. These findings suggest that IMT could support weaning processes in intensive care, although larger studies are needed.Öğe Skeletal muscle alterations in type 2 diabetes mellitus with and without dyslipidemia(BioMed Central Ltd, 2025) Satman, Ilhan; Dayican, Damla Korkmaz; Calikoglu, Fulya; Sahin, Humeyra Rekali; Perone, Francesco; Akinci, BuketBackground Diabetic dyslipidemia, a common comorbidity in people with type 2 diabetes, has been reported to be associated with adverse metabolic outcomes. Skeletal muscle is a key organ impacted by metabolic disorders; however, the specific effects of diabetic dyslipidemia on skeletal muscle mass, strength, and performance remain unclear. The aim of this study was to assess the skeletal muscle alterations of people with type 2 diabetes with and without dyslipidemia. Methods This retrospective study included 144 participants (mean age 51.3 +/- 7.1 years; 103 female, 41 male) aged 40-65 years. Body composition was assessed using bioelectrical impedance analysis (BIA), muscle strength via dynamometer, and functional capacity with the 6-minute walk test (6MWT). To minimize the confounding effect of longer diabetes duration in the diabetic dyslipidemia group, propensity score matching (PSM) was performed using a 1:1 nearest-neighbor method. All analyses were performed on matched groups. ROC analysis was conducted for variables showing significant differences. Results After PSM, people with diabetic dyslipidemia showed significantly lower skeletal muscle mass and skeletal muscle index (SMI), higher body fat percentage, and reduced 6MWD compared to those with diabetes alone (p < 0.05). In women with diabetic dyslipidemia, handgrip strength was significantly lower. ROC analysis revealed moderate predictive value for skeletal muscle mass (AUC = 0.682), SMI (AUC = 0.654), and 6MWD (AUC = 0.628). Conclusion This study demonstrated that people with diabetic dyslipidemia had lower skeletal muscle mass, SMI, and decreased physical performance compared to people with diabetes alone, even after matching for diabetes duration. These findings demonstrate early sarcopenic and dynapenic changes and highlight the need to consider skeletal muscle health and lipid abnormalities together in diabetes management.Öğe Volumetric Three-Dimensional Evaluation of the Pharyngeal Airway After Orthognathic Surgery in Patients with Skeletal Class III Malocclusion(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Oz, Aslihan Zeynep; El, Hakan; Palomo, Juan MartinBackground: Orthognathic surgery significantly alters the dimensions of the pharyngeal airway. This study's objective was to assess alterations in the pharyngeal airway volume via cone-beam computed tomography (CBCT) after orthognathic surgery in patients with skeletal Class III malocclusion. Methods: This retrospective study analyzed CBCT images from 23 patients with skeletal Class III malocclusion (13 females, 10 males), who were categorized into two groups based on the surgical approach: double-jaw and single-jaw surgery. The double-jaw group included 13 patients who underwent bilateral sagittal split osteotomy (BSSO) and Le Fort I osteotomy, whereas the single-jaw group included of 10 patients who had underwent BSSO only. CBCT images were evaluated both before surgery and at a minimum of three months after surgery. The oropharyngeal volume (OP), nasopharyngeal volume (NP), total airway volume, posterior airway space (PAS), and the most constricted area at the base of the tongue (minAx) were measured. Statistical analyses were performed using either paired t-tests or Wilcoxon signed-rank tests depending on data normality, with a significance level set at p < 0.01. Results: In the double-jaw group, a significant volumetric increase was observed in the nasopharynx (5316 +/- 1948 mm(3) to 6064 +/- 1899 mm(3); p = 0.010) and oropharyngeal volume decreased from 17,097 +/- 5675 mm(3) to 14,290 +/- 5835 mm(3); however, this reduction was not statistically significant (p = 0.017). In contrast, the single-jaw group showed a significant reduction in oropharyngeal volume from 15,620 +/- 5040 mm(3) to 12,444 +/- 4701 mm(3) (p = 0.010), with no significant change in nasopharyngeal volume (p = 0.551). Total airway volume significantly decreased only in the single-jaw group (from 20,452 +/- 7754 mm(3) to 16,846 +/- 6529 mm(3), p = 0.010). Additionally, both groups exhibited marked decreases in PAS and minimum axial area values (all p < 0.01). Conclusions: Orthognathic surgery led to a significant volumetric increase in the nasopharynx in the double-jaw group, whereas the oropharynx volume significantly decreased only in the single-jaw group. Additionally, both surgical approaches resulted in a marked reduction in PAS and minimum axial area values, highlighting a notable impact on posterior airway dimensions.Öğe Anatomical Relationship of the Mylohyoid Ridge, Lingual Concavity, and Mandibular Canal: A Retrospective CBCT Study(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Girit, Melike Nur; Ansen, Gamze; Pence, Kadriye Betul; Yuzbasioglu, NeslihanBackground/Objective: This study aimed to determine the position of the mylohyoid ridge (MR) and lingual concavity (LC) in the mandible and their relationship with the mandibular canal (MC) and submandibular fossa, to provide anatomical guidance for surgical procedures in this region. Methods: A retrospective analysis was performed on cone beam computed tomography (CBCT) scans from 200 adult patients who had undergone imaging for dental treatment. On cross-sectional images at the level between the first and second molar roots, the following measurements were obtained: LC horizontal depth, LC height, LC depth, MR height, MR depth, and the distances from MR to MC (MR–MC) and LC to MC (LC–MC). Results: Mean values were: LC horizontal depth: 3.72 ± 0.90 mm, LC height: 11.74 ± 2.01 mm, LC depth: 12.54 ± 3.03 mm, MR height: 17.66 ± 2.60 mm, MR depth: 6.87 ± 2.38 mm, MR-MC: 8.30 ± 2.00 mm, and LC-MC: 3.72 ± 0.87 mm. All parameters were symmetrical between the right and left sides of the mandible, with no significant sex differences. The positions of the MR and LC were related to each other, and the position of the MC was related to the positions of the LC and MR. There was no correlation between the horizontal depth of the LC and the position of the MR, LC and MC. Conclusions: The vertical positions of the MR and LC are related to each other and MC. Therefore, it can be used as a landmark in implant surgery.Öğe AlzFormer: Video-based space-time attention model for early diagnosis of Alzheimer’s disease(Elsevier, 2025) Akan, Taymaz; Alp, Sait; Ledbetter, Christina Raye; Bhuiyan, Mohammad Alfrad NobelEarly and accurate Alzheimer’s disease (AD) diagnosis is critical for effective intervention, but it is still challenging due to neurodegeneration’s slow and complex progression. Recent studies in brain imaging analysis have highlighted the crucial roles of deep learning techniques in computer-assisted interventions for diagnosing brain diseases. In this study, we propose AlzFormer, a novel deep learning framework based on a space–time attention mechanism, for multiclass classification of AD, MCI, and CN individuals using structural MRI scans. Unlike conventional deep learning models, we used spatiotemporal self-attention to model inter-slice continuity by treating T1-weighted MRI volumes as sequential inputs, where slices correspond to video frames. Our model was fine-tuned and evaluated using 1.5 T MRI scans from the ADNI dataset. To ensure the anatomical consistency of all the MRI data, All MRI volumes were pre-processed with skull stripping and spatial normalization to MNI space. AlzFormer achieved an overall accuracy of 94 % on the test set, with balanced class-wise F1-scores (AD: 0.94, MCI: 0.99, CN: 0.98) and a macro-average AUC of 0.98. We also utilized attention map analysis to identify clinically significant patterns, particularly emphasizing subcortical structures and medial temporal regions implicated in AD. These findings demonstrate the potential of transformer-based architectures for robust and interpretable classification of brain disorders using structural MRIÖğe Radiological analysis of palatal arterial anatomy for periodontal surgery: insights from 3D-RA(Springer-Verlag Italia s.r.l., 2025) Bozay Oz, Evrim; Oz, Ibrahim IlkerObjective: This study aimed to comprehensively evaluate the detailed arterial anatomy of the palatal mucosa, emphasising the greater palatine artery (GPA) and lesser palatine artery (LPA), through the use of three-dimensional rotational angiography (3D-RA). This detailed vascular analysis aims to inform clinical decisions and reduce the risk of vascular injury during palatal graft harvesting procedures. Methods: A retrospective analysis of radiological data was conducted on 80 consecutive patients who underwent cerebral or carotid digital subtraction angiography (DSA) incorporating 3D-RA imaging. Detailed measurements were obtained for the GPA, descending palatine artery (DPA), and LPA, including arterial diameters, branching patterns, and their spatial relationships with palatal mucosal thickness and vault morphology. Based on GPA and LPA branching patterns, the vascular supply to the hard palate was classified. Results: The GPA was classified into three branching patterns, with Type I (absence of medial branch) being most prevalent (65%), typically accompanied by the presence of LPA contributions to the medial hard palate. Type II (MB coursing anterior to the palatal spine) was identified in 23.75% of patients. Type III was present in 11.25%, The mean diameter of the GPA was 0.99 ± 0.16 mm, while the DPA was significantly larger in males (p = 0.036). The GPA’s lateral branch narrowed anteriorly, with the smallest mucosal-to-vessel distance measured at the first premolar region (2.55 ± 1.11 mm), indicating a heightened risk for surgical injury. No significant relationship was found between palatal vault morphology and mucosal thickness. Conclusion: The LPA contributed to medial hard palate perfusion in the absence of the GPA’s medial branch, indicating its surgical relevance in mucogingival procedures.
