Scopus İndeksli Yayınlar Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.12941/3

Listeleniyor 1 - 20 / 119

Machine learning–assisted classification of lung cancer: the role of sarcopenia, inflammatory biomarkers, and PET/CT anatomical-metabolic parameters
(Springer Science and Business Media Deutschland GmbH, 2025) Tanyildizi-Kokkulunk, Handan; Alcin, Goksel; Cavdar, Iffet; Akyel, Resit; Ciftci-Kusbeci, Tuba; Caliskan, Gonul
Accurate differentiation between non-cancerous, benign, and malignant lung cancer remains a diagnostic challenge due to overlapping clinical and imaging characteristics. This study proposes a multimodal machine learning (ML) framework integrating positron emission tomography/computed tomography (PET/CT) anatomic-metabolic parameters, sarcopenia markers, and inflammatory biomarkers to enhance classification performance in lung cancer. A retrospective dataset of 222 patients was analyzed, including demographic variables, functional and morphometric sarcopenia indices, hematological inflammation markers, and PET/CT derived parameters such as maximum and mean standardized uptake value (SUVmax, SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG). Five ML algorithms—Logistic Regression, Multi-Layer Perceptron, Support Vector Machine, Extreme Gradient Boosting, and Random Forest—were evaluated using standardized performance metrics. Synthetic Minority Oversampling Technique was applied to balance class distributions. Feature importance analysis was conducted using the optimal model, and classification was repeated using the top 15 features. Among the models, Random Forest demonstrated superior predictive performance with a test accuracy of 96%, precision, recall, and F1-score of 0.96, and an average AUC of 0.99. Feature importance analysis revealed SUVmax, SUVmean, total lesion glycolysis, and skeletal muscle index as leading predictors. A secondary classification using only the top 15 features yielded even higher test accuracy (97%). These findings underscore the potential of integrating metabolic imaging, physical function, and biochemical inflammation markers in a non-invasive ML-based diagnostic pipeline. The proposed framework demonstrates high accuracy and generalizability and may serve as an effective clinical decision support tool in early lung cancer diagnosis and risk stratification.
Salvia argentea L. extract inhibits the production of NO, and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), alleviates the inflammatory response of LPS-induced macrophages cells, and reduces the CRP level on carrageenan-induced paw edema
(Springer Science and Business Media Deutschland GmbH, 2025) Alhamedi, Almonther; Demiroz Akbulut, Tugce; Baykan, Sura; Gümüştaş, Barış; Sanci, Ebru; Alsakini, Karrar Ali Mohammed Hasan; Nalbantsoy, Ayşe; Yavasoğlu, Altuğ; Karabay Yavasoğlu, N. Ülkü
Salvia argentea L. (Lamiaceae) is a medicinal plant originating from the Mediterranean region and has been used since ancient times for the treatment of various diseases. This study aimed to determine the phytochemical composition of S. argentea L. ethanol extract and to evaluate its in vitro and in vivo anti-inflammatory activity and its acute oral toxicity. The chemical constituents of the ethanol extract prepared from the aerial parts of the plant were identified using HPLC. The in vitro anti-inflammatory activity of the extract was evaluated in LPS-stimulated murine macrophage RAW 264.7 cells and the human monocytic cell line THP-1 by measuring the levels of nitric oxide (NO), pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Acute toxicity of the extract was assessed in accordance with OECD guideline no 423. In vivo anti-inflammatory activity was evaluated based on the inhibition of 1% carrageenan-induced paw edema in rats. Serum CRP levels as an inflammatory marker, were measured via ELISA. Histological and immunohistochemical assessments were performed to identify tissue changes in the paw. HPLC profiling revealed that the extract contained rosmarinic acid (11.334 µg/mg dry extract), and salvigenin (2.74 µg/mg of dry extract) as major compounds. The extract significantly inhibited the production of NO, IL-1β, IL-6, and TNF-α without affecting cell viability. In vivo, the extract treatment exhibited a dose-dependent reduction in paw edema and serum CRP levels, along with notable histological improvements. Administration of the extract resulted in dose-dependent decreases of NF-κB expressions in the paw tissues. No signs of acute toxicity were observed (oral LD₅₀ > 2000 mg/kg). These findings suggest that S. argentea L. ethanol extract possesses significant anti-inflammatory potential supporting its possible development as a natural therapeutic agent for inflammatory disorders.
From unmet childhood needs to parenting attitudes: breaking the cycle
(Taylor and Francis, 2025)
Objective: Rooted in Schema Therapy, this research posits that unmet physiological, social, and psychological needs during early life contribute to the development of enduring cognitive frameworks, termed early maladaptive schemas (EMS), which influence affect, behaviour, and cognition across the lifespan. Accordingly, the objective was to examine whether EMSs are systematically associated with specific parenting attitudes (PAs). Method: This correlational study employed a concurrent design. Participants included 246 volunteer parents of preschool-aged children residing in a cosmopolitan district of Istanbul. Data were collected online using validated measures of EMS and PA, along with additional items assessing potential confounding variables. Results: Correlational analyses revealed moderate positive associations between EMS and authoritarian parenting attitudes and moderate negative associations with democratic parenting attitudes. Hierarchical regression analyses showed that EMS accounted for over 20% of the variance in parenting attitudes, with socioeconomic status and education emerging as significant moderators. Discussion: EMSs significantly predict parenting attitudes, increasing authoritarian attitudes, and reducing democratic ones. Early identification of EMS, combined with schema-focused interventions and evidence-based parent education programs may help disrupt maladaptive parenting cycles and promote healthier parent–child dynamics.
Representation of the City in Cinema: An Analysis of Kars Architecture as a Film Setting
(Ataturk Universitesi, 2025) Öztürk, Sezer Volkan
Due to cinema’s utilization of architecture as a filming location, the collaboration that has developed between these two disciplines has enabled the historical heritage of cities to be reflected on the silver screen. In this way, large audiences have become familiar with these cities through cinematic representation. As a border city that has experienced numerous occupations over time, Kars possesses a rich architectural, historical, and cultural background. These features have attracted the attention of many directors and screenwriters, and the city has taken on an almost leading role in several significant films. In this study, the ability of cinema to combine visuality and narrative has been examined through the spatial representation of the city of Kars in film. To analyze Kars’s cinematic representation from a multifaceted perspective and to obtain comparable data, a scene-content analysis was conducted on three films selected via a random sampling method. The spatial settings in these selected films were analyzed semiotically, focusing on their visual and symbolic meanings. Through this approach, the interaction between the city and its cinematic representation over time has been explored. Ultimately, the elements conveyed indirectly to the viewer constitute the foundation of semiotics, forming codes whose meanings are gradually interpreted by the audience. These codes, as presented through the films, contribute to the construction of a collective subconscious that reflects either an authentic or fictionalized image of the city and its society. As a result, the locations where films are shot are marketed either positively or negatively, intentionally or unintentionally. The findings of the analysis reveal that in the selected films, Kars is commonly represented through a rural narrative framework and is employed not as a realistic urban setting but rather as a fictionalized cinematic space. - Sinemanın mimarlığı bir çekim mekânı olarak kullanması nedeniyle bu iki disiplin arasında gelişen işbirliği; şehirlerin sahip olduğu tarihsel mirasın beyaz perdeye yansımasına, bu da çok sayıda insanın bu şehirleri sinema yoluyla kolayca tanımasına sebep olmuştur. Kars’ın sınır şehri olması ve yıllar içerisinde çok sayıda işgale uğraması sebebiyle şehrin mimarisi, tarihi ve kültürü zenginliklerle doludur. Bu zenginlikler günümüzde çok sayıda yönetmen ve senarist tarafından ilgi çekici bulunmuş ve şehir değerli birçok filmde adeta bir başrol oyuncusu gibi yer almıştır. Bu çalışmada, sinema sanatının sahip olduğu görseli ve anlatıyı bir araya getirme becerisi; Kars şehrinin sinemadaki temsili üzerinden okunmuştur. Kars'ın sinemadaki temsiliyetini çok yönlü inceleyebilmek ve karşılaştırabilir veri elde edebilmek adına; rastgele örnekleme yöntemiyle seçilen üç film üzerinden sahne-içerik analizi yapılmış ve film mekanları göstergebilimsel olarak incelenmiştir. Seçili filmlerdeki bu mekânların görsel ve sembolik anlamları, Kars'ın sinema sanatındaki temsili üzerinden okunarak yıllar içerisinde şehirle nasıl bir etkileşimde bulunduğu irdelenmiştir. Sonuçta dolaylı olarak seyirciye hissettirilen öğeler göstergebilimin temelini oluştururken seyircinin aslında ne anlama geldiğini zamanla kavradığı kodları meydana getirmektedir. Filmler ile verilen bu kodlar şehre ve topluma ait doğru veya kurgulanmış bir ortak bilinçaltı oluşturmaktadır. Neticede sinemanın çekildiği mekân olumlu veya olumsuz anlamda pazarlanmış olmaktadır. İncelenen filmlerde Kars şehri için kırsal bir anlatım dilinin ortak olarak tespit edildiği ve şehrin sinema mekânı olarak gerçek değil, kurgusal olarak kullanıldığı sonucuna varılmıştır.
The Effect of Osteopathic Manipulative Treatment Adjunct on Stabilization Splint Treatment in Temporomandibular Joint Anterior Disc Displacement with Reduction Disorder: A Quantitative Analysis, Pilot Study
(MDPI, 2025) Aklar, Ayca; Bal, Burcu; Tasdelen, Neslihan; Ertas, Gokhan
Objective: This study aimed to quantitatively assess the efficacy of osteopathic manipulative treatment (OMT) as an adjunct to stabilization splint treatment for temporomandibular joint anterior disc displacement with reduction (ADDwR) disorder. Method: Thirty-eight joints were evaluated in this study. OMT, in addition to splint treatment, was administered to the study group, and the control group only received splint treatment. Before and after the treatments, the quality of life, the pain levels of distinct body regions, and the sleep quality were evaluated, while mandibular movements were assessed and condyle–disc position differences measured on magnetic resonance images. Results: In all the life qualities, except social functionality, increases after treatment were present for both control and study groups, but the increase was significant in bodily pain for the control group (p = 0.034) while increases were significant in physical functionality (p = 0.018), general health perception (p = 0.027), and reported health transition (p = 0.019) for the study group. Significant pain reduction in all body regions was seen in the study groups (p = 0.007–0.033), but the decrease was only significant for the temporomandibular joint for the control group (p = 0.011). The sleep quality significantly improved for the study group (p = 0.018). Limited after-treatment improvements in the condyle–disc positions were determined for both the normal joints and joints with ADDwR in the study group. Conclusions: The application of OMT adjunct to splint treatment increases quality of life and sleep, reduces bodily pain, and improves condyle–disc positions over the MRIs of TMJ.
The Relationship Between Lip Augmentation and Teeth Visibility: A Cosmetic Perspective
(Lippincott Williams and Wilkins, 2025) Altin, Fazilet; Muluk, Nuray Bayar; Cingi, Cemal
Objectives: This paper aims to describe the ideal relationship between lips and teeth as 2 critical facial features to guide young doctors keen on lip augmentation. Methods: The literature survey was performed in PubMed, EBSCO, UpToDate, Proquest Central databases of Kirikkale University, and Google and Google Scholar databases. Results: There is a relationship between the visibility of teeth and the amount of tooth show and its attractiveness, but only if the gingival exposure is within the standard setting and between the upper central incisor tips if the buccal corridor is not exceeding 1 mm. A smile's visual expression and aesthetics do not simply involve the lips alone. Facial esthetics result from harmony between several minor factors, the combination of which determines the patient's overall appearance. For instance, when laughing with an open mouth, a person's teeth become visible. The need for lip enhancement is based on the patient's aesthetic goals, infrastructural tooth position/visibility, and stage of facial aging. To help achieve lip augmentation goals, facial aesthetic subunits, soft-tissue patterns, and bony landmarks should be considered. Lip augmentation is typically performed by adding volume through various means and materials. Conclusions: The authors must offer essential new data on the relationship between lip augmentation and teeth visibility. A given upper lip enhancement will make the maxillary incisors visible to a greater or lesser extent. However, there is limited research on what constitutes a prioritized single most crucial factor in promoting maxillary incisor visibility.
Skeletal muscle alterations in type 2 diabetes mellitus with and without dyslipidemia
(BioMed Central Ltd, 2025) Satman, Ilhan; Dayican, Damla Korkmaz; Calikoglu, Fulya; Sahin, Humeyra Rekali; Perone, Francesco; Akinci, Buket
Background Diabetic dyslipidemia, a common comorbidity in people with type 2 diabetes, has been reported to be associated with adverse metabolic outcomes. Skeletal muscle is a key organ impacted by metabolic disorders; however, the specific effects of diabetic dyslipidemia on skeletal muscle mass, strength, and performance remain unclear. The aim of this study was to assess the skeletal muscle alterations of people with type 2 diabetes with and without dyslipidemia. Methods This retrospective study included 144 participants (mean age 51.3 +/- 7.1 years; 103 female, 41 male) aged 40-65 years. Body composition was assessed using bioelectrical impedance analysis (BIA), muscle strength via dynamometer, and functional capacity with the 6-minute walk test (6MWT). To minimize the confounding effect of longer diabetes duration in the diabetic dyslipidemia group, propensity score matching (PSM) was performed using a 1:1 nearest-neighbor method. All analyses were performed on matched groups. ROC analysis was conducted for variables showing significant differences. Results After PSM, people with diabetic dyslipidemia showed significantly lower skeletal muscle mass and skeletal muscle index (SMI), higher body fat percentage, and reduced 6MWD compared to those with diabetes alone (p < 0.05). In women with diabetic dyslipidemia, handgrip strength was significantly lower. ROC analysis revealed moderate predictive value for skeletal muscle mass (AUC = 0.682), SMI (AUC = 0.654), and 6MWD (AUC = 0.628). Conclusion This study demonstrated that people with diabetic dyslipidemia had lower skeletal muscle mass, SMI, and decreased physical performance compared to people with diabetes alone, even after matching for diabetes duration. These findings demonstrate early sarcopenic and dynapenic changes and highlight the need to consider skeletal muscle health and lipid abnormalities together in diabetes management.
Exploring the Causal Links between ESG, R&D, and Firm Performance: Evidence from the US Technology and Food Companies
(Institute of Geography of the Slovak Academy of Science, 2025) Boğa Şahin, Semra; Bozkurt, Gözde; Gillpatrick, Tom
This study examines the causal relationships between ESG (Environmental, Social, and Governance) compliance, R&D expenditures, and financial performance in the technology and food sectors in the US. A panel dataset from 2012 – 2021 from the Thomson Reuters database was analysed for 12 food and 18 technology companies. The findings show that there are different causal relationships between sectors. While R&D investments in the technology sector positively affect firm performance by increasing ESG compliance, firm performance in the food sector directs ESG compliance, encouraging R&D investments. The study emphasizes that sectoral differences should be considered in sustainability and R&D strategies and guides policymakers and managers to develop approaches appropriate to the dynamics of the sector.
Volumetric Three-Dimensional Evaluation of the Pharyngeal Airway After Orthognathic Surgery in Patients with Skeletal Class III Malocclusion
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Oz, Aslihan Zeynep; El, Hakan; Palomo, Juan Martin
Background: Orthognathic surgery significantly alters the dimensions of the pharyngeal airway. This study's objective was to assess alterations in the pharyngeal airway volume via cone-beam computed tomography (CBCT) after orthognathic surgery in patients with skeletal Class III malocclusion. Methods: This retrospective study analyzed CBCT images from 23 patients with skeletal Class III malocclusion (13 females, 10 males), who were categorized into two groups based on the surgical approach: double-jaw and single-jaw surgery. The double-jaw group included 13 patients who underwent bilateral sagittal split osteotomy (BSSO) and Le Fort I osteotomy, whereas the single-jaw group included of 10 patients who had underwent BSSO only. CBCT images were evaluated both before surgery and at a minimum of three months after surgery. The oropharyngeal volume (OP), nasopharyngeal volume (NP), total airway volume, posterior airway space (PAS), and the most constricted area at the base of the tongue (minAx) were measured. Statistical analyses were performed using either paired t-tests or Wilcoxon signed-rank tests depending on data normality, with a significance level set at p < 0.01. Results: In the double-jaw group, a significant volumetric increase was observed in the nasopharynx (5316 +/- 1948 mm(3) to 6064 +/- 1899 mm(3); p = 0.010) and oropharyngeal volume decreased from 17,097 +/- 5675 mm(3) to 14,290 +/- 5835 mm(3); however, this reduction was not statistically significant (p = 0.017). In contrast, the single-jaw group showed a significant reduction in oropharyngeal volume from 15,620 +/- 5040 mm(3) to 12,444 +/- 4701 mm(3) (p = 0.010), with no significant change in nasopharyngeal volume (p = 0.551). Total airway volume significantly decreased only in the single-jaw group (from 20,452 +/- 7754 mm(3) to 16,846 +/- 6529 mm(3), p = 0.010). Additionally, both groups exhibited marked decreases in PAS and minimum axial area values (all p < 0.01). Conclusions: Orthognathic surgery led to a significant volumetric increase in the nasopharynx in the double-jaw group, whereas the oropharynx volume significantly decreased only in the single-jaw group. Additionally, both surgical approaches resulted in a marked reduction in PAS and minimum axial area values, highlighting a notable impact on posterior airway dimensions.
Anatomical Relationship of the Mylohyoid Ridge, Lingual Concavity, and Mandibular Canal: A Retrospective CBCT Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Girit, Melike Nur; Ansen, Gamze; Pence, Kadriye Betul; Yuzbasioglu, Neslihan
Background/Objective: This study aimed to determine the position of the mylohyoid ridge (MR) and lingual concavity (LC) in the mandible and their relationship with the mandibular canal (MC) and submandibular fossa, to provide anatomical guidance for surgical procedures in this region. Methods: A retrospective analysis was performed on cone beam computed tomography (CBCT) scans from 200 adult patients who had undergone imaging for dental treatment. On cross-sectional images at the level between the first and second molar roots, the following measurements were obtained: LC horizontal depth, LC height, LC depth, MR height, MR depth, and the distances from MR to MC (MR–MC) and LC to MC (LC–MC). Results: Mean values were: LC horizontal depth: 3.72 ± 0.90 mm, LC height: 11.74 ± 2.01 mm, LC depth: 12.54 ± 3.03 mm, MR height: 17.66 ± 2.60 mm, MR depth: 6.87 ± 2.38 mm, MR-MC: 8.30 ± 2.00 mm, and LC-MC: 3.72 ± 0.87 mm. All parameters were symmetrical between the right and left sides of the mandible, with no significant sex differences. The positions of the MR and LC were related to each other, and the position of the MC was related to the positions of the LC and MR. There was no correlation between the horizontal depth of the LC and the position of the MR, LC and MC. Conclusions: The vertical positions of the MR and LC are related to each other and MC. Therefore, it can be used as a landmark in implant surgery.
Exploring the financial impact of digital transformation: A comprehensive analysis on firms
(Elsevier B.V., 2025) Yavuz, Melih Sefa; Bozkurt, Gözde
This study aims for an in-depth exploration into the effects of digital transformation on firms’ financial performance and how this impact can be measured. The research employs a two-stage method to evaluate firms’ digitalization processes. In the first stage, keywords related to digitalization are extracted from annual reports through text mining, and digital transformation strategies in five different sectors are analyzed. Based on these analyses, the return of digitalization (ROD) ratio is developed to assess the effects of digital transformation. In the second stage, a panel data analysis is conducted to examine the impact of digitalization and the ROD ratio on a firm's performance. The research findings clearly indicate that digital transformation generates positive effects on firms’ financial performance. It also appears that digitalization provides a competitive advantage, particularly in areas such as operational efficiency and brand value. Firms with a high ROD ratio, which can be used as an indicator of digital transformation investments, demonstrate stronger financial performance. The ROD ratio has emerged as a critical indicator that effectively measures the financial outcomes of digital transformation.
Organizational and Individual Antecedents of Resistance to Change: Organizational Climate and Technology Readiness
(Sciendo, 2025) Eyitmiş, Ahmet Melih; Zümrüt, Muhammet Zeki
Background and purpose: There is interest in barriers to change in organizations. This research discusses factors affecting resistance to change based on employees’ technological competencies. This research aims to determine the mediating role of technology readiness in the effect of organizational climate in health institutions on resistance to change. Methodology: Research data were collected from 389 employees working in the healthcare sector. SPSS Process 2.13 macro was used to analyze the model. Results: According to the analysis results, organizational climate positively affected technology readiness. Additionally, organizational climate reduced resistance to change. In addition, employees’ readiness for technology reduced resistance to change. Finally, the mediating role of technology readiness (motivating and blocking factors) in the effect of organizational climate on resistance to change was significant. Further, a positive organizational climate in healthcare institutions increased employees’ readiness for new technologies and significantly reduced employees’ resistance to change. Conclusion: Creating a positive organizational climate can be vital in successfully implementing change processes in the healthcare sector. At the end of the research, theoretical and practical suggestions were presented. The research contributes to the literature by addressing the antecedents of resistance to change from organizational and individual perspectives.
Radiological analysis of palatal arterial anatomy for periodontal surgery: insights from 3D-RA
(Springer-Verlag Italia s.r.l., 2025) Bozay Oz, Evrim; Oz, Ibrahim Ilker
Objective: This study aimed to comprehensively evaluate the detailed arterial anatomy of the palatal mucosa, emphasising the greater palatine artery (GPA) and lesser palatine artery (LPA), through the use of three-dimensional rotational angiography (3D-RA). This detailed vascular analysis aims to inform clinical decisions and reduce the risk of vascular injury during palatal graft harvesting procedures. Methods: A retrospective analysis of radiological data was conducted on 80 consecutive patients who underwent cerebral or carotid digital subtraction angiography (DSA) incorporating 3D-RA imaging. Detailed measurements were obtained for the GPA, descending palatine artery (DPA), and LPA, including arterial diameters, branching patterns, and their spatial relationships with palatal mucosal thickness and vault morphology. Based on GPA and LPA branching patterns, the vascular supply to the hard palate was classified. Results: The GPA was classified into three branching patterns, with Type I (absence of medial branch) being most prevalent (65%), typically accompanied by the presence of LPA contributions to the medial hard palate. Type II (MB coursing anterior to the palatal spine) was identified in 23.75% of patients. Type III was present in 11.25%, The mean diameter of the GPA was 0.99 ± 0.16 mm, while the DPA was significantly larger in males (p = 0.036). The GPA’s lateral branch narrowed anteriorly, with the smallest mucosal-to-vessel distance measured at the first premolar region (2.55 ± 1.11 mm), indicating a heightened risk for surgical injury. No significant relationship was found between palatal vault morphology and mucosal thickness. Conclusion: The LPA contributed to medial hard palate perfusion in the absence of the GPA’s medial branch, indicating its surgical relevance in mucogingival procedures.
Balance and biomechanics: exploring lower extremity biomechanics in Parkinson’s disease
(Springer Science and Business Media Deutschland GmbH, 2025) Duzenli, Senanur; Gunduz, Merve Sevinc; Yilmaz, Aysen Elif; Erdal, Yuksel; Mustafaoğlu, Rüstem
Background: Postural instability (PI) is a symptom seen in 16% of Parkinson Disease (PD) patients and has limited response to dopaminergic therapy. Understanding the factors contributing to PI, such as biomechanical changes, is important for the development of non-pharmacological treatment. Aims: To investigate the relationship between lower extremity biomechanics and balance parameters in PD patients. Methods: A total of 18 participants (n = 9 female) were enrolled in the study. Lower extremity biomechanics were evaluated using a combination of measurements, including femoral anteversion angle, Q angle, leg length, navicular drop test (NDT), gastrocnemius shortness, range of motion (ROM) assessments, and the Foot Posture Index (FPI). Balance was assessed through the Postural Stability Test, Fall Risk Index (FRI), and the Mini-BESTest. Results: A significant correlation was observed between FRI and femoral anteversion (r = 0.58, p = 0.011) as well as hip flexion ROM (r = 0.67, p = 0.002) and lateral malleoli curvature (r = 0.48, p = 0.04). Overall Stability Index (OSI) was significantly associated with NDT (r = 0.53, p = 0.024) and forefoot abduction/adduction (r = 0.67, p = 0.002). The Anteroposterior Stability Index (APSI) correlated with NDT (r = 0.47, p = 0.048), knee flexion ROM (r = 0.47, p = 0.045), and forefoot abduction/adduction (r = 0.65, p = 0.004). Moreover, Mini-BESTest scores were associated with hip abduction (r = 0.55, p = 0.017), ankle plantar flexion (r = 0.63, p = 0.005), and knee flexion ROM (r = 0.47, p = 0.048). Conclusions: This study demonstrated that lower extremity biomechanical features, including alignment and joint mobility, are significantly linked to balance and fall risk in individuals with PD. Incorporating biomechanical assessments into clinical evaluations may aid in developing individualized treatment strategies for balance disorders in PD.
Clinical and molecular results in 15 Turkish patients with Wiedemann-Steiner syndrome: identification of eight novel KMT2A variants and a case of dual molecular diagnosis in the CSNK2A1
(Springer Science and Business Media Deutschland GmbH, 2025) Yeter, Burcu; Demirkol, Yasemin Kendir; Usluer, Esra; Oğuz, Sümeyra; Eser, Metin; Yarar, Murat Hakkı; Canbek, Sezin
Wiedemann-Steiner syndrome (WSS) is a rare autosomal dominant neurogenetic disorder caused by monallelic variants in KMT2A gene, characterized by neuromotor developmental delay, intellectual disability, microcephaly, seizures, behavioral disorders, dysmorphic facial features, hirsutism, and systemic anomalies. The KMT2A gene encodes a histone lysine methyltransferase crucial for the regulation of gene expression during early developmental stages. In this study, the clinical and molecular findings of 15 Turkish patients with WSS confirmed by whole exome sequencing are reported. Variant segregation was confirmed in all families. The ages of the patients were between 1.5 and 16 years. The majority of patients had neuromotor developmental delay, speech delay, and intellectual disability. The most frequently recognised dysmorphic facial features were thick eyebrows, long eyelashes, synophrys, hypertelorism, and broad nose. Other frequently observed clinical findings included short stature, congenital hypotonia, behavioral problems, genitourinary anomalies, and abnormal gait. Novel findings included focal segmental glomerulosclerosis, cholelithiasis, and sacrococcygeal teratoma. Fifteen different KMT2A variants were detected, including 8 novel (p.Gln3594*, p.Glu1407Argfs*4, p.Ser610Ilefs*9, p.Ser2188Leufs*25, p.Glu970Glnfs*37, p.Ser759Valfs*22, p.Lys1346Serfs*24, and c.11146 + 1_11146 + 6delinsA) variants. Additionally, one patient exhibited a dual molecular diagnosis with a de novo variant in CSNK2A1, associated with Okur-Chung neurodevelopmental syndrome. Conclusion: This study expands the clinical and molecular spectrum of WSS, highlighting novel variants and unique manifestations. It emphasizes the importance of molecular testing in accurate diagnosis and management. By characterizing phenotypic diversity and dual diagnosis, this work contributes valuable insights for advancing clinical care and guiding future research. (Table presented.)
Neuropsychiatry of psychological resilience: An overview
(Istanbul Medipol University, 2025) Eroğlu, İpek; Macit, Çağlar; Gezgin, Ulaş Başar; Omurtağ, Gülden Zehra; Himmetoğlu, Asena
Psychological resilience is the operational software of competencies that enables us to cope positively with life’s drawbacks. As with all competencies and associated skills, the level of psychological resilience may vary among in-dividuals. This research addresses the neuropsychiatric dimension of psychological resilience and discusses its potential applications in improving public health and pharmacy practices. To conduct a modeling study to identify, di-agnose and disseminate to the society the individual characteristics that con-stitute the building blocks of a resilient society that will cope with pandemics, climate change, wars, waves of migration, inability to meet the basic needs of the increasing population and infrastructure problems, global economic crisis, technological challenges, digital transformation pressure, disruptive changes, and the VUCA (volatility, uncertainty, complexity, ambiguity) world environ-ment, led us to a detailed literature review. Neuropsychiatry of psychological resilience is exemplified by recent global developments, biological underpinnings, genetic variations, clinical perspectives, and developmental aspects.
Development and Evaluation of an Electronic Nursing Process System for Cardiology Nurses Based on the Functional Health Patterns Model
(Lippincott Williams and Wilkins, 2025) Enç, Nuray; Türen, Sevda; Şendir, Merdiye
The research was conducted to develop and evaluate an electronic nursing process system for cardiology nurses according to the functional health patterns model. A design-based research method was used, in which quantitative and qualitative research methods were used together. The sample of the study consisted of 25 cardiology nurses working in a university hospital who had not used a system created according to the functional health patterns model before and 8 subject matter experts. A snowball sampling method was used. The research process was carried out within the framework of the five cycles of design-based research: analysis, design, development, implementation, and evaluation. Face-to-face interviews were used to collect data from nurses and subject matter experts regarding the features that the ideal electronic nursing process system will create according to the functional health patterns model. After the system was developed in accordance with these data, the system was tested three times by the nurses and experts in the sample group on 11 defined tasks in terms of effectiveness, efficiency, and satisfaction of the participants, using success rate and completion time criteria through observations of effectiveness and efficiency. The satisfaction level was measured through semistructured interviews with the sample group. Data were analyzed using content analysis. The system was redeveloped based on the findings obtained after analyzing the data collected after each test. With the last development made after the third test, the system was given its final form. At the end of the study, it was revealed that the electronic nursing process system developed according to the functional health patterns model for cardiology nurses was effective and efficient and the satisfaction level of the users with the system was high.
The automation trap: Unpacking the consequences of over-reliance on AI in education and its hidden costs
(IGI Global, 2025)
With the growing presence of artificial intelligence (AI) in classrooms, its influence on how students think, learn, and interact deserves close scrutiny. However, its increasing integration and accessibility raise concerns about AI dependency among students. Excessive reliance on AI may weaken essential cognitive skills, including critical thinking, problem-solving, and creativity, which are crucial for academic and professional success. Moreover, diminished human interaction with teachers and peers threatens the human aspect of education. This chapter critically examines the risks of AI over-reliance, emphasizing its long-term consequences on student development. Left unchecked, this dependency may lead to superficial learning and hinder the cultivation of independent thought. The normalization of AI-generated outputs may also blur the line between authentic learning and algorithmic convenience. It highlights the shift from AI as a supportive tool to a potential source of dependency and advocates for a more balanced, human-centered integration of technology in education.
The effect of endurance-based sports on athlete success and psychological well-being
(Campus EDUCA SPORTIS S.L., 2025) Özpinar, Saliha; Yüce, Ali Serdar; Korkmaz, Murat; Öztaş, Dilek; Aras, Gökşen
The aim of this study is to examine the effects of psychological resilience on sport success and mental health. The relationships between commitment, control and challenge, which are sub-dimensions of psychological resilience, and sport success and psychological well-being were evaluated and discussed in detail. Today, the problems arising due to the increasing competitive environment and stress factors have made it more important for athletes to be psychologically strong. Although the relationship between psychological resilience and sport success has been previously examined in the literature, studies evaluating the individual effects of the sub-dimensions of resilience in a large sample group are quite limited. This study aims to overcome this deficiency and make an up-to-date contribution to the subject. A total of 684 students (72 percent male, 28 percent female) studying at the Faculties of Sport Sciences of 16 universities in Istanbul, Ankara, Izmir, Bursa and Antalya participated in the study. Participants completed the Resilience Scale and Mental Health Inventory, and their sporting achievements were evaluated by their coaches using the Sport Achievement Scale. Data were collected via Google Forms® and analysed using SPSS 22.0 software with correlation, regression and Granger causality tests. The findings revealed that all resilience sub-dimensions showed positive and significant relationships with sport achievement (R²=0.93) and psychological well-being (R²=0.68). Especially control and challenge factors had the strongest effects. As a result of the research, commitment, control and challenge, which are the sub-dimensions of psychological resilience, significantly affect both success levels and psychological well-being of athletes. Therefore, resilience development programmes for athletes should focus on these areas.
Investigation of the Cross-Norm Inhibition Effect Through Theoretical Links and Hypothetical Examples
(Routledge, 2025) Kaya Cicerali, Lütfiye
The Cross-Norm Inhibition Effect (CNIE) offers an alternative approach to shaping behavior, maintaining order, and preventing crime by recognizing the interconnected nature of social norms. This article explores CNIE’s theoretical foundations and demonstrates its potential impact at different social levels through hypothetical examples. Practical guidance is provided for applying CNIE within families, organizations, and communities. As the most comprehensive international study of CNIE to date, it shows how strategic interventions can trigger a domino effect that promotes positive behaviors. CNIE could become a valuable tool for governments, families, and businesses in building a safer, more harmonious society.

Güncel Gönderiler