Exploring the Relationship Between HMGB1, CXCL12, CXCR4, and CXCR7 in the Context of Adriamycin-Induced Cardiotoxicity

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dc.contributor.authorEmrence, Zeliha
dc.contributor.authorPunar, Şeyma
dc.contributor.authorTaşkın, Eylem
dc.contributor.authorGüven, Celal
dc.contributor.authorSarıman, Melda
dc.contributor.authorAbacı,Neslihan
dc.date.accessioned2024-09-16T07:07:06Z
dc.date.available2024-09-16T07:07:06Z
dc.date.issued2024
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Temel Bilimler Bölümü
dc.description.abstractHigh-mobility group box-1 (HMGB1), known as an abundant and highly conserved nuclear protein, plays a pivotal role in initiating inflammation, tissue healing, and the immune response following various forms of cell damage. The chemokine C-X-C motif chemokine ligand 12 (CXCL12) forms a signaling axis known as CXCL12/ CXCR4/CXCR7, along with the receptors CXCR4 and CXCR7. Our study aimed to explore the connection between HMGB1 and the involved chemokine axis, CXCR4, CXCL12, and CXCR7, in the context of adriamycin-induced cardiotoxicity. Materials and Methods: We performed RNA interference to suppress HMGB1 expression in H9c2 cardiac myoblast cells. Adriamycin, an anti-tumor antibiotic known for causing cardiotoxicity, was used in conjunction with HMGB1 suppression. We investigated the combined and individual effects of these factors. Gene expression analysis was conducted through qRT-PCR 36 and 48 h post-treatment. Results: Adriamycin treatment increased the expression of CXCL12, CXCR4, and CXCR7. Notably, our study observed significant changes in gene expression when HMGB1 was downregulated and adriamycin was administered. These findings suggest potential molecular mechanisms associated with adriamycin-induced cardiotoxicity, emphasizing the significance of the CXCR4/CXCL12 axis and the impact of HMGB1 modulation. Conclusion: Our study provides insights into the molecular interplay between HMGB1 and the CXCL12/CXCR4/CXCR7 ligand-receptor axis in the context of adriamycin-induced cardiotoxicity. The results shed light on further research to enhance therapeutic approaches or advance new strategies to address this cardiotoxicity.
dc.identifier.citationEMRENCE, Z., Punar, S., Taskin, E., Guven, C., Sariman, M., & ABACI, N., (2024). Exploring the Relationship Between HMGB1, CXCL12, CXCR4, and CXCR7 in the Context of Adriamycin-Induced Cardiotoxicity. Experimed , vol.14, no.2, 63-67.en_US
dc.identifier.doi10.26650/experimed.1427537
dc.identifier.endpage67
dc.identifier.issn2667-5846
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85202747565
dc.identifier.scopusqualityN/A
dc.identifier.startpage63
dc.identifier.urihttps://hdl.handle.net/20.500.12941/256
dc.identifier.volume14
dc.indekslendigikaynakScopus
dc.institutionauthorSarıman, Melda
dc.language.isoen
dc.relation.ispartofExperimed
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdriamycin
dc.subjectCardiotoxicity
dc.subjectCXCL12
dc.subjectCXCR4
dc.subjectCXCR7
dc.subjectGene expression
dc.subjectHMGB1
dc.titleExploring the Relationship Between HMGB1, CXCL12, CXCR4, and CXCR7 in the Context of Adriamycin-Induced Cardiotoxicity
dc.typeArticle

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