Investigation of the Relationship Between Heavy Metals (Cadmium, Arsenic, and Lead) and Metallothionein in Multiple Sclerosis

Basit Öğe Kaydı
dc.contributor.authorKeçecioğlu, Can
dc.contributor.authorSarıkaya, Cansu
dc.contributor.authorAydın, Ahmet
dc.contributor.authorCharehsaz, Mohammad
dc.contributor.authorEfendi, Hüsnü
dc.date.accessioned2024-08-27T14:00:48Z
dc.date.available2024-08-27T14:00:48Z
dc.date.issued2024
dc.departmentMeslek Yüksekokulları, Meslek Yüksekokulu, Eczane Hizmetleri Programı
dc.description.abstractBackground and aim: Multiple sclerosis (MS) is one of the most common neurological disorders. Metals are important for the maintenance and preservation of homeostasis and dysregulated metal homeostasis has an impact on neurodegeneration. Environmental factors are considered to contribute to MS risk and progression. Heavy metals such as arsenic (As), cadmium (Cd), and lead (Pb) are widely found in the environment and because of their toxic nature, they pose a great danger to human health. Metallothioneins (MTs) play important roles in metal homeostasis and detoxification of heavy metals. Objective: The aim of this study was to investigate the relationship between levels of heavy metals (As, Cd, and Pb) and MT levels in MS patients and also to assess the oxidative stress status of patients. Method: Fifty subjects (20 healthy subjects and 30 MS patients) were included. Demographic characteristics of the patients, plasma MT levels, blood Cd, As, and Pb levels, as well as iron (Fe), copper (Cu), and zinc (Zn) levels, were determined. Malondialdehyde (MDA) levels were investigated as a marker of oxidative stress. Results: MT levels were slightly higher in the MS group (p > 0.05). As Cd and Pb levels were significantly higher in the control subjects. MDA levels were significantly higher in MS patients. Conclusion: Our results support the relevance of MT and MDA levels in MS. Further clinical studies with larger cohorts will provide more insights into these factors.
dc.identifier.citationKeçecioğlu C, Sarıkaya C, Aydın A, et al. (August 13, 2024) Investigation of the Relationship Between Heavy Metals (Cadmium, Arsenic, and Lead) and Metallothionein in Multiple Sclerosis. Cureus 16(8): e66754. DOI 10.7759/cureus.66754en_US
dc.identifier.doi10.7759/cureus.66754
dc.identifier.endpage14
dc.identifier.issn2168-8184
dc.identifier.issue8
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.12941/240
dc.identifier.volume16
dc.identifier.wosWOS:001295568700008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorKeçecioğlu, Can
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofCureus Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMultipl skleroz
dc.subjectMultiple sclerosis
dc.subjectMetalotiyonin
dc.subjectMetallothionein
dc.subjectÇevresel faktörler
dc.subjectEnvironmental factors
dc.titleInvestigation of the Relationship Between Heavy Metals (Cadmium, Arsenic, and Lead) and Metallothionein in Multiple Sclerosis
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Investigation of the.pdf
Boyut:
1.11 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Meslek Yüksekokulu Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu