Intelligent Periodontics: Integrating Artificial Intelligence and Nanotechnology in Next-Generation Prosthetic Dentistry

This review explores how combining artificial intelligence and nanotechnology can reshape periodontics and prosthetic dentistry by enabling more precise, predictive, and personalized care. It first outlines the conceptual foundations of intelligent periodontics, emphasizing data driven decision making, the shift from conventional to digital workflows, and the integration of AI into routine diagnostic and therapeutic processes. The paper then examines current AI applications in periodontal diagnosis, disease progression prediction, and prosthodontic workflows, highlighting improvements in imaging analysis, treatment planning, and prosthesis design. In parallel, it reviews nanotechnology based strategies for periodontal regeneration, implant surface modification, antimicrobial coatings, and targeted drug delivery, focusing on their contribution to enhanced tissue integration and long term clinical performance. The convergence section discusses AI assisted design and optimization of nanomaterials, smart and responsive nano systems, and data driven development of next generation implants and prostheses. Clinical translation challenges including nanotoxicity, data privacy, algorithmic bias, regulatory gaps, cost, and training needs are critically analyzed, alongside future trends such as nanorobotics, AI enabled precision prosthodontics, and IoT based smart oral devices. Overall, the review provides a structured framework for responsibly integrating AI and nanotechnology into modern periodontal and prosthetic practice, aiming to support more effective, safe, and patient centered dental care. © 2026 Tehran University of Medical Sciences. All rights reserved.