Psychopathological Analysis of Adolescent Girls With Autoimmune Thyroiditis

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dc.authoridGresa Çarkaxhiu Bulut / 0000-0002-0582-4936
dc.contributor.authorAydın, Engin
dc.contributor.authorAydın, Dilek Bingöl
dc.contributor.authorBulut, Gresa Çarkaxhiu
dc.contributor.authorİşgüven, Şükriye Pınar
dc.date.accessioned2024-06-12T08:12:41Z
dc.date.available2024-06-12T08:12:41Z
dc.date.issued2023
dc.departmentFakülteler, Sanat ve Sosyal Bilimler Fakültesi, Psikoloji Bölümü
dc.description.abstractAim: Clinical studies indicate that there is an association between high levels of thyroid autoantibodies and psychiatric disorders, independent of impairment of thyroid function. Therefore, we aimed to investigate the association between thyroid autoimmunity and mood disorders in euthyroid girls with Hashimoto's thyroiditis (HT) in a case-control study.Material and methods: We recruited 82 participants: 41 pubertal female patients with thyroiditis from endocrine outpatient clinics and a control group of 41 healthy pubertal girls from the University Hospital. Age ranged from 12 to 18 years; the diagnosis of HT was based on high levels of anti-TPO and/or anti-Tg antibodies associated with a hypoechogenic or normal thyroid ultrasound pattern. Other comorbidities known to affect mental and physical health were exclusion factors. All participants underwent a complete thyroid evaluation, assays of serum-free T4, TSH, anti-TPO antibodies, anti-Tg antibodies, and thyroid ultrasonography. They were then referred to a child psychiatrist. A psychiatric diagnosis was made in two steps. First, the Children's Depression Inventory (CDI) and Screen for Child Anxiety-Related Emotional Disorders (SCARED) tests were implemented according to the DSM-IV diagnostic criteria to be calculated. Second, the same psychiatrist conducted a K-SADS-PL semi-structured interview while unaware of the children's data.Results: There was no significant difference in CDI score between patients with and without HT (p = 0.47). Patients with HT had significantly higher SCARED scores than patients without HT (p < 0.05). In the SCARED test, the subcategories of separation anxiety and social anxiety were significantly higher in the HT group (p = 0.04 and p = 0.01, respectively). During the K-SADS interview by the attending child psychiatrist, psychopathology diagnoses were detected in 27 of 41 patients (66%) with HT and in 8 of 41 individuals (19.5%) in the control group. Psychopathology was significantly higher in the HT group (p < 0.01). The incidences of depressive disorder, generalized anxiety disorder, and social phobia were significantly higher in the HT group than in the control group (p < 0.05). Multivariate logistic regression analysis revealed that the anti-TPO value was the most significant independent risk factor for the presence of depressive disorder (p < 0.01).Conclusion: This study described severe psychometric impairment in patients with euthyroid HT. We have demonstrated that autoimmune thyroid diseases, even in a euthyroid state, are associated with psychiatric disorders.
dc.identifier.citationAydin, E., Bingöl Aydin, D., Çarkaxhiu Bulut, G., & İşgüven, Ş. P. (2023). Psychopathological Analysis of Adolescent Girls With Autoimmune Thyroiditis. Cureus, 15(12), e50418. https://doi.org/10.7759/cureus.50418en_US
dc.identifier.doi10.7759/cureus.50418
dc.identifier.issn2168-8184
dc.identifier.issue12
dc.identifier.urihttps://hdl.handle.net/20.500.12941/212
dc.identifier.volume15
dc.identifier.wosWOS:001127080800022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorBulut, Gresa Çarkaxhiu
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofCureus Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectErgen
dc.subjectAdolescent
dc.subjectEndişe
dc.subjectAnxiety
dc.subjectOtoimmünite
dc.subjectAutoimmunity
dc.subjectHaşimato hastalığı
dc.subjectHashimoto disease
dc.subjectDepresyon
dc.subjectDepression
dc.subjectk-üzüntüler
dc.subjectk-sads
dc.titlePsychopathological Analysis of Adolescent Girls With Autoimmune Thyroiditis
dc.typeArticle

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