The İmportance of hematological parameters in the prognosis of patients with severe COVID-19, A single-center retrospective study

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dc.contributor.authorGözüküçük, Ramazan
dc.contributor.authorKılıç, Hasan Hüseyin
dc.contributor.authorUyanık, Bekir Sami
dc.contributor.authorÇakıroğlu, Basri
dc.date.accessioned2025-01-02T15:40:31Z
dc.date.available2025-01-02T15:40:31Z
dc.date.issued2023
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Temel Bilimler Bölümü
dc.description.abstractBackground: Inflammation biomarkers known as acute phase reactants (APRs) show significant variations in serum concentrations during inflammation brought on by both viral and noninfectious diseases. The erythrocyte sedimentation rate (ESR), the C-reactive protein (CRP), the lactate dehydrogenase (LDH), the ferritin, the fibrinogen, the procalcitonin, the D-dimer, and the troponin I are all significant APRs. During inflammation, the serum levels of each of these positive APRs rise. The sensitivity and specificity of hematologic parameters and indices are as high as the inflammatory biomarkers mentioned above for monitoring disease severity and treatment response. Aim: We aimed to evaluate the differences in hematological parameters and indices, and to reveal their treatment and prognostic values, especially in deceased patients with COVID-19. Materials and Methods: The hemogram parameters of 169 critical patients with COVID-19 (125 males and 44 females) who received inpatient treatment at horizontal ellipsis . between 1 March 2020 and 31 December 2021 were analyzed retrospectively. The patients were divided into two groups-deceased (77) and surviving (92)-noting demographic data such as age and gender. All analyses were performed using SPSS 25.0. Results: Analyses of the hematological parameters used during the treatment processes revealed statistically significant differences between the two patient groups. White blood cell (WBC), neutrophil, and neutrophil-to-lymphocyte ratio (NLR) values were significantly higher (P = 0.019, P = 0.000 and P = 0.000, respectively) for deceased subjects, while lymphocyte, platelet and plateletcrit (PCT) values were significantly lower (for all values, P = 0.000). Platelet volume (MPV) and platelet distribution width (PDW), as well as MPV/PLT, PDW/PLT, MPV/PCT, and PDW/PCT, levels were significantly higher in deceased subjects (P = 0.000). Particularly in our deceased cases, receiver operating characteristic analyses were performed to reveal the importance of such analyses in prognostic status evaluation in COVID-19 since the hematological parameters are quite different. Cut-off values were determined for each parameter, and sensitivity and specificity ratios were calculated. While the sensitivities of MPV/PLT, PDW/PLT, MPV/PCT, and PDW/PCT indices are over 80%, neutrophil and white blood cell sensitivities were found to be lower (74%, 68.8%, respectively). Conclusion: In addition to NLR, which is an important biomarker, the hematological indices MPV/PLT, PDW/PLT, MPV/PCT, and PDW/PCT can be used to determine the risk of death in patients with severe COVID-19.
dc.identifier.citationGozukucuk, R., Kılıc, H. H., Uyanik, B. S., & Cakiroglu, B. (2023). The İmportance of hematological parameters in the prognosis of patients with severe COVID-19, A single-center retrospective study. Nigerian journal of clinical practice, 26(9), 1297–1302. https://doi.org/10.4103/njcp.njcp_22_23
dc.identifier.doi10.4103/njcp.njcp_22_23
dc.identifier.endpage1302
dc.identifier.issn1119-3077
dc.identifier.issue9
dc.identifier.pmid37794542
dc.identifier.scopusqualityQ2
dc.identifier.startpage1297
dc.identifier.urihttps://hdl.handle.net/20.500.12941/274
dc.identifier.volume26
dc.identifier.wos001098863800011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGözüküçük, Ramazan
dc.institutionauthorUyanık, Bekir Sami
dc.institutionauthorÇakıroğlu, Basri
dc.institutionauthoridRamazan Gözüküçük / 0000-0002-8205-4752
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCovid-19
dc.subjectHemogram
dc.subjectMpv/Pct
dc.subjectMpv/Plt
dc.subjectNeutrophil-To-Lymphocyte Ratio
dc.subjectPredicting Prognosis
dc.subjectPlatelet Indexes
dc.subjectLymphocyte Ratio
dc.subjectNeutrophil
dc.subjectMortality
dc.subjectDisease
dc.titleThe İmportance of hematological parameters in the prognosis of patients with severe COVID-19, A single-center retrospective study
dc.typeArticle

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