Investigating the potential clinical impact of periodontitis on the progression of Alzheimer’s disease : a prospective cohort study

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dc.authorid0000-0002-1738-371X
dc.contributor.authorKaraduran, Kübra
dc.contributor.authorAydoğdu, Ahmet
dc.contributor.authorGelisin, Özlem
dc.contributor.authorGünpınar, Sadiye
dc.date.accessioned2024-01-12T11:16:51Z
dc.date.available2024-01-12T11:16:51Z
dc.date.issued2024
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Diş Hekimliği
dc.description.abstractAbstract Objectives This study aimed to investigate the efect of periodontitis and current occlusal relationship on the progression rate of Alzheimer’s disease (AD). Methods Ninety Alzheimer’s patients, who were divided into three groups as Stage I (n=42), Stage II (n=29), and Stage III (n=19), based on the Clinical Dementia Rating Scale, were included in the study. Cognitive status of the patients was evaluated with Standardized Mini-Mental Test (SMMT) at baseline and repeated 6 months later. Clinical periodontal examinations were recorded and occlusal relationship status was classifed according to the Eichner Index. Results Of 90 Alzheimer’s patients, 65 were toothed individuals with periodontitis and 25 were edentulous individuals without active periodontal disease. Stage II and Stage III toothed Alzheimer’s patients had higher percentage of bleeding on probing (BOP%) and clinical attachment level (CAL) values than Stage I patients (p<0.05). Stage III Alzheimer’s patients had signifcantly higher probing pocket depth (PPD) values than Stage I individuals (p<0.05). ?SMMT values showed positive correlation with BOP% (r=0.308, p=0.013) and PPD (r=0.275, p=0.027). Among the evaluated parameters, being in the AD Stage II–Stage III, having periodontitis and age variable had signifcant efects on ?SMMT levels (p<0.05). Conclusions Within the limits of our study, it can be concluded that periodontitis may increase the severity and also accelerate the progression rate of AD. Clinical relevance These results are precious to show the necessity of proper oral hygiene activities and regular dental visits in patients with toothed AD. Clinical trial registration This study was registered and approved by clinical trials (NCT05807100).
dc.identifier.citationKubra Karaduran, Ahmet Aydoğdu, Özlem Gelişin, & Sadiye Günpınar. (2024). Investigating the potential clinical impact of periodontitis on the progression of Alzheimer’s disease: a prospective cohort study. Clinical Oral Investigations, 28(1). ‌en_US
dc.identifier.doi10.1007/s00784-023-05445-w
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85180889089
dc.identifier.scopusqualityQ1
dc.identifier.startpage67
dc.identifier.urihttps://hdl.handle.net/20.500.12941/177
dc.identifier.volume28
dc.identifier.wosWOS:001132766800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAydoğdu, Ahmet
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlzheimer hastalığı
dc.subjectBilişsel gerileme
dc.subjectPeriodontal hastalık
dc.subjectTıkanma
dc.subjectPeriodontitis
dc.subjectÇiğneme
dc.subjectAlzheimer’s disease
dc.subjectCognitive decline
dc.subjectPeriodontal disease
dc.subjectOcclusion
dc.subjectChewing
dc.titleInvestigating the potential clinical impact of periodontitis on the progression of Alzheimer’s disease : a prospective cohort study
dc.typeArticle

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