Does the variant positivity and negativity affect the clinical course in COVID-19?: a cohort study

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dc.authoridSüleyman Hilmi Aksoy / 0000-0002-2356-0268
dc.authoridRamazan Gözüküçük / 0000-0002-8205-4752
dc.contributor.authorYıldırım, Erkan
dc.contributor.authorKılıçkan, Levent
dc.contributor.authorAksoy, Süleyman Hilmi
dc.contributor.authorGözüküçük, Ramazan
dc.contributor.authorKılıç, Hasan Hüseyin
dc.contributor.authorTomak, Yakup
dc.contributor.authorDalkılıç, Orhan
dc.contributor.authorTanboğa, İbrahim Halil
dc.contributor.authorKılıçkan, Fevzi Duhan Berkan
dc.date.accessioned2023-03-16T12:17:28Z
dc.date.available2023-03-16T12:17:28Z
dc.date.issued2023
dc.departmentMeslek Yüksekokulları, Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programı
dc.description.abstractThe primary aim of the current study is to analyze the clinical, laboratory, and demographic data comparing the patients with Coronavirus Disease 2019 (COVID-19) admitted to our intensive care unit before and after the UK variant was first diagnosed in December 2020. The secondary objective was to describe a treatment approach for COVID-19. Between Mar 12, 2020, and Jun 22, 2021, 159 patients with COVID-19 were allocated into 2 groups: the variant negative group (77 patients before December 2020) and the variant positive group (82 patients after December 2020). The statistical analyses included early and late complications, demographic data, symptoms, comorbidities, intubation and mortality rates, and treatment options. Regarding early complications, unilateral pneumonia was more common in the variant (-) group (P = .019), whereas bilateral pneumonia was more common in the variant (+) group (P < .001). Regarding late complications, only cytomegalovirus pneumonia was observed more frequently in the variant (-) group (P = .023), whereas secondary gram (+) infection, pulmonary fibrosis (P = .048), acute respiratory distress syndrome (ARDS) (P = .017), and septic shock (P = .051) were more common in the variant (+) group. The therapeutic approach showed significant differences in the second group such as plasma exchange and extracorporeal membrane oxygenation which is more commonly used in the variant (+) group. Although mortality and intubation rates did not differ between the groups, severe challenging early and late complications were observed mainly in the variant (+) group, necessitating invasive treatment options. We hope that our data from the pandemic will shed light on this field. Regarding the COVID-19 pandemic, it is clear that there is much to be done to deal with future pandemics.
dc.identifier.citationYildirim, E., Kilickan, L., Aksoy, S. H., Gozukucuk, R., Kilic, H. H., Tomak, Y., Dalkilic, O., Tanboga, I. H., & Kilickan, F. D. B. (2023). Does the variant positivity and negativity affect the clinical course in COVID-19?: A cohort study. Medicine, 102(9), e33132. https://doi.org/10.1097/md.0000000000033132en_US
dc.identifier.doi10.1097/MD.0000000000033132
dc.identifier.endpage8
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85149314312
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1097/MD.0000000000033132
dc.identifier.urihttps://hdl.handle.net/20.500.12941/123
dc.identifier.volume102
dc.identifier.wosWOS:000942400000056
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAksoy, Süleyman Hilmi
dc.institutionauthorGözüküçük, Ramazan
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComplications
dc.subjectCoronavirus disease 19
dc.subjectCOVID-19 variants
dc.subjectMortality
dc.subjectSARS-CoV-2
dc.titleDoes the variant positivity and negativity affect the clinical course in COVID-19?: a cohort study
dc.typeArticle

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