Management of microcomplications of diabetes mellitus: Challenges, current trends, and future perspectives in treatment

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dc.authorid0000-0001-8259-521X
dc.contributor.authorYapışlar, Hande
dc.contributor.authorGürler, Esra Bihter
dc.date.accessioned2024-12-24T12:41:46Z
dc.date.available2024-12-24T12:41:46Z
dc.date.issued2024
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Temel Bilimler Bölümü
dc.description.abstractDiabetes mellitus is a chronic metabolic disorder characterized by high blood sugar levels, which can lead to severe health issues if not managed effectively. Recent statistics indicate a significant global impact, with 463 million adults diagnosed worldwide and this projected to rise to 700 million by 2045. Type 1 diabetes is an autoimmune disorder where the immune system attacks pancreatic beta cells, reducing insulin production. Type 2 diabetes is primarily due to insulin resistance. Both types of diabetes are linked to severe microvascular and macrovascular complications if unmanaged. Microvascular complications, such as diabetic retinopathy, nephropathy, and neuropathy, result from damage to small blood vessels and can lead to organ and tissue dysfunction. Chronic hyperglycemia plays a central role in the onset of these complications, with prolonged high blood sugar levels causing extensive vascular damage. The emerging treatments and current research focus on various aspects, from insulin resistance to the intricate cellular damage induced by glucose toxicity. Understanding and intervening in these pathways are critical for developing effective treatments and managing diabetes long term. Furthermore, ongoing health initiatives, such as increasing awareness, encouraging early detection, and improving treatments, are in place to manage diabetes globally and mitigate its impact on health and society. These initiatives are a testament to the collective effort to combat this global health challenge.
dc.identifier.citationYapislar, H., & Gurler, E. B. (2024). Management of Microcomplications of Diabetes Mellitus: Challenges, Current Trends, and Future Perspectives in Treatment. Biomedicines, 12(9), 1958. https://doi.org/10.3390/biomedicines12091958
dc.identifier.doi10.3390/biomedicines12091958
dc.identifier.endpage25
dc.identifier.issn2227-9059
dc.identifier.issue9
dc.identifier.pmid39335472
dc.identifier.scopus2-s2.0-85205079028
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/biomedicines12091958
dc.identifier.urihttps://hdl.handle.net/20.500.12941/271
dc.identifier.volume12
dc.identifier.wosWOS:001322863700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürler, Esra Bihter
dc.institutionauthorid0000-0001-8259-521X
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofBiomedicines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes Mellitus
dc.subjectType 2 Diabetes Mellitus
dc.subjectInsulin Resistance
dc.subjectHyperglycemia
dc.subjectDiabetic Retinopathy
dc.subjectDiabetic Nephropathy
dc.subjectDiabetic Neuropathy
dc.subjectMicrovascular Complications
dc.titleManagement of microcomplications of diabetes mellitus: Challenges, current trends, and future perspectives in treatment
dc.typeReview Article

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