An analysis of phase angle and standard phase angle cut-off values and their association with survival in head and neck cancer patients undergoing radiotherapy

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dc.authoridDilşat Baş / 0000-0002-2991-7774
dc.contributor.authorBaş, Dilşat
dc.date.accessioned2023-07-27T09:09:40Z
dc.date.available2023-07-27T09:09:40Z
dc.date.issued2023
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective The objective of this study is to identify the cutoff values for phase angle (PA) and standard phase angle (SPA) parameters, as determined by bioelectrical impedance analysis (BIA), for predicting malnutrition and investigating their association with overall survival in head and neck cancer (HNC) patients undergoing radiotherapy. Methods In this study, nutritional assessment and follow-up of HNC patients undergoing radiotherapy (RT) between November 2017 and September 2022 were assessed. Nutritional assessment, body composition (BC), and PA results obtained from BIA (Tanita MC-980) were retrospectively evaluated. Statistical Package for Social Sciences (SPSS) version 25.0 (IBM Corp., Armonk, NY, USA) was used for statistical analysis. The results were evaluated at a confidence interval of 95% and a significance level of p ? 0.05. Results A total of 53 patients, including 37 (70%) men and 16 (30%) women, with a median age of 60 (23–87 years) were included. The median follow-up time was 51 (range 24–59) months. The mean PA of the patients was calculated as 4.99° (±0.92, 95% CI: 4.74–5.25). The PA of patients with malnutrition (4.66° ± 0.87) was lower than that of well-nourished patients (5.71° ± 0.56) (p < 0.001). As a result of the ROC analysis based on this finding, the ideal PA cut-off point for determining the presence of malnutrition was found to be 5.65, with a sensitivity of 85%, specificity of 79%, accuracy of 83%, and a model discrimination power of excellent level (AUC: 85%, p < 0.001). The median overall survival time of the patients was calculated as 51 months (24–59 months). The mortality rate during the follow-up period was 13%, while the 1-, 3-, and 5-year overall survival rates of the patients were 96.1%, 89.3%, and 86.8%, respectively. Patients with SPA values less than -1.65 had a 5-year overall survival rate of 77.4%, while those with SPA values greater than or equal to -1.65 had a 5-year overall survival rate of 100% (p = 0.030) Conclusion Our study recommends using PA and SPA as standard criteria for detecting malnutrition in HNC patients undergoing RT, with cut-off points of 5.65 and -1.65 respectively, to prevent treatment interruptions and improve outcomes. Further research is needed to validate the SPA cut-off value and its relationship with clinical outcomes, as SPA may be a more effective predictor of malnutrition and overall survival than PA alone.
dc.identifier.citationDilşat Baş, Ceren Atahan, & Tjon, T. (2023). An Analysis of Phase Angle and Standard Phase Angle Cut-off Values and Their Association with Survival in Head and Neck Cancer Patients Undergoing Radiotherapy. 42(8), 1445–1453. https://doi.org/10.1016/j.clnu.2023.06.020en_US
dc.identifier.doi10.1016/j.clnu.2023.06.020
dc.identifier.endpage1453
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.issue8
dc.identifier.scopus2-s2.0-85164717166
dc.identifier.scopusqualityQ1
dc.identifier.startpage1445
dc.identifier.urihttp://dx.doi.org/10.1016/j.clnu.2023.06.020
dc.identifier.urihttps://hdl.handle.net/20.500.12941/149
dc.identifier.volume42
dc.identifier.wosWOS:001043702800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaş, Dilşat
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofClinical Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhase angle
dc.subjectStandard phase angle
dc.subjectMalnutrition
dc.subjectHead and neck cancer
dc.subjectOverall survival
dc.subjectBody composition analysis
dc.titleAn analysis of phase angle and standard phase angle cut-off values and their association with survival in head and neck cancer patients undergoing radiotherapy
dc.typeArticle

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