Enamel Matrix Derivative, 58S5 Bioactive Glass, and Fluoride Varnish for Enamel Remineralization: A Multi-analysis Approach

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dc.authoridAyça Sarıalioğlu Güngör / 0000-0002-8779-2949
dc.contributor.authorGüngör Sarıalioğlu, Ayça
dc.contributor.authorDalkılıç, Evrim
dc.contributor.authorAlkan, Elif
dc.contributor.authorYılmaz Atalı, Pınar
dc.contributor.authorTağtekin, Dilek
dc.date.accessioned2024-06-11T08:40:38Z
dc.date.available2024-06-11T08:40:38Z
dc.date.issued2024
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.description.abstractPURPOSE: This study aimed to evaluate the enamel remineralization efficacy of enamel matrix derivative (EMD), experimental bioactive glass (BAG), and fluoride varnish in vitro. METHODS AND MATERIALS: Artificial initial caries lesions were developed on fifty human enamel specimens using demineralization solution (pH 4.5, 37°C, 96 hours). Specimens were randomly assigned to five groups (n=10): I-5% NaF varnish (Enamelast), II-experimental 58S5 BAG+37% phosphoric acid (PA), III-EMD (Emdogain) + Ethylenediaminetetraacetic Acid (EDTA), IV-EMD+37% PA, V-Control (untreated). All remineralization agents were applied with pH cycling for seven days. The specimens were scanned by spectral domain optical coherence tomography (SD-OCT) at baseline, at demineralization, and after pH cycling. Lesion depths were measured using image analysis software (ImageJ). Lesions were evaluated using surface microhardness (SMH) and two fluorescence methods (FluoreCam and DIAGNOdent Pen [DDPen]). The data were statistically analyzed by Kruskal Wallis, Friedman, and Wilcoxon tests (?=0.05). RESULTS: According to SD-OCT results, fluoride varnish was found to be the most effective agent in reducing lesion depth (p=0.005). All agents increased the SMH values after pH cycling. No significant difference was found among fluoride varnish, BAG, and EMD+PA groups. These SMH values were significantly higher than EMD+EDTA and control groups (p<0.001). All groups showed lower DDPen scores compared with the control group (p<0.001), however, no significant difference was found among the remineralization agents. In FluoreCam assessment, size and intensity values of all treated groups showed improvement. However, there was no significant difference between the treatment groups in terms of FluoreCam size measurements (p=0.186). CONCLUSION: 58S5 BAG and EMD+PA have remineralization capacity as effective as fluoride varnish. EMD+PA showed better SMH and lesion intensity results than EMD+EDTA.
dc.identifier.citationGungor, A. S., Dalkılıç, E., Alkan, E., Yılmaz-Atalı, P., & Tağtekin, D. (2024). Enamel Matrix Derivative, 58S5 Bioactive Glass, and Fluoride Varnish for Enamel Remineralization: A Multi-analysis Approach. Operative dentistry, 49(3), 353–363. https://doi.org/10.2341/23-102-Len_US
dc.identifier.doi10.2341/23-102-l
dc.identifier.endpage363
dc.identifier.issn0361-7734
dc.identifier.issn1559-2863
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85194854381
dc.identifier.scopusqualityQ1
dc.identifier.startpage353
dc.identifier.urihttps://hdl.handle.net/20.500.12941/209
dc.identifier.volume49
dc.identifier.wosWOS:001248259300004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüngör Sarıalioğlu, Ayça
dc.language.isoen
dc.relation.ispartofOperative dentistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleEnamel Matrix Derivative, 58S5 Bioactive Glass, and Fluoride Varnish for Enamel Remineralization: A Multi-analysis Approach
dc.typeArticle

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